Small Angle Scattering Biological Data Bank SASBDB

SASBDB entries for UniProt ID: P21333

SASDFH3 – Filamin A Ig-like domains 4-6, H743P mutant (FLNa4-6 H743P) at 2 mg/ml

UniProt ID: P21333 (574-869) Filamin A Ig-like domains 4-6, H743P mutation

Filamin A Ig-like domains 4-6, H743P mutation experimental SAS data

Filamin A Ig-like domains 4-6, H743P mutation Kratky plot

Sample:	Filamin A Ig-like domains 4-6, H743P mutation monomer, 31 kDa Homo sapiens protein
Buffer:	20 mM Tris, 100 mM NaCl, 1 mM DTT, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2017 Feb 10

Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia. Biophys J 117(8):1467-1475 (2019)
Haataja TJK, Capoulade R, Lecointe S, Hellman M, Merot J, Permi P, Pentikäinen U

R_g^Guinier	4.0	nm
D_max	15.3	nm
Volume^Porod	60	nm³

SASDEQ7 – Filamin A Ig-like domains 3-5 (FLNa3-5)

UniProt ID: P21333 (478-766) Filamin A Ig-like domains 3-5

Filamin A Ig-like domains 3-5 experimental SAS data

Sample:	Filamin A Ig-like domains 3-5 monomer, 31 kDa Homo sapiens protein
Buffer:	20 mM Tris, 100 mM NaCl, 1 mM DTT, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2017 Feb 10

Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A. Structure (2018)
Haataja TJK, Bernardi RC, Lecointe S, Capoulade R, Merot J, Pentikäinen U

R_g^Guinier	2.2	nm
D_max	7.3	nm
Volume^Porod	39	nm³

SASDEP7 – Filamin A Ig-like domains 3-5 P637Q mutant (FLNa3-5 P637Q)

UniProt ID: P21333 (478-766) Filamin A Ig.like domains 3-5 P637Q mutant

Filamin A Ig.like domains 3-5 P637Q mutant experimental SAS data

Sample:	Filamin A Ig.like domains 3-5 P637Q mutant monomer, 31 kDa Homo sapiens protein
Buffer:	20 mM Tris, 100 mM NaCl, 1 mM DTT, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2017 Feb 10

R_g^Guinier	2.2	nm
D_max	7.4	nm
Volume^Porod	39	nm³

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