SASBDB entries for UniProt ID: P45481

SASDF37 – KIX domain (kinase-inducible domain interacting domain) of CREB-binding protein (Mus musculus), mutation L664C

UniProt ID: P45481 (586-672) Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C
Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C experimental SAS data
DAMMIN model
Sample: Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C monomer, 10 kDa Mus musculus protein
Buffer: 25 mM Hepes, 150 NaCl, 1 mM DTT, 5% Glycerol, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 May 27
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein. J Biol Chem (2019)
Garg A, Orru R, Ye W, Distler U, Chojnacki JE, Köhn M, Tenzer S, Sönnichsen C, Wolf E
RgGuinier 1.9 nm
Dmax 8.1 nm

SASDF47 – Complex of CBP KIX domain with BMAL1 (D530-L625) including C-terminal transactivation domain (TAD) (Mus musculus)

UniProt ID: Q9WTL8-2 (530-625) Aryl hydrocarbon receptor nuclear translocator-like protein 1

UniProt ID: P45481 (586-672) Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C
Aryl hydrocarbon receptor nuclear translocator-like protein 1Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C experimental SAS data
DAMMIN model
Sample: Aryl hydrocarbon receptor nuclear translocator-like protein 1 monomer, 10 kDa Mus musculus protein
Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C monomer, 10 kDa Mus musculus protein
Buffer: 25 mM Hepes, 150 NaCl, 1 mM DTT, 5% Glycerol, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 May 27
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein. J Biol Chem (2019)
Garg A, Orru R, Ye W, Distler U, Chojnacki JE, Köhn M, Tenzer S, Sönnichsen C, Wolf E
RgGuinier 2.8 nm
Dmax 11.5 nm

SASDF57 – Complex of CBP KIX domain with BMAL1 (G517-L625) including C-terminal transactivation domain (TAD) (Mus musculus)

UniProt ID: Q9WTL8-2 (517-625) Brain and muscle ARNT-like 1 (G517-L625) including transactivation domain (TAD)

UniProt ID: P45481 (586-672) Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP)
Brain and muscle ARNT-like 1 (G517-L625) including transactivation domain (TAD)Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP) experimental SAS data
DAMMIN model
Sample: Brain and muscle ARNT-like 1 (G517-L625) including transactivation domain (TAD) monomer, 11 kDa Mus musculus protein
Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP) monomer, 10 kDa Mus musculus protein
Buffer: 25 mM Hepes, 150 NaCl, 1 mM DTT, 5% Glycerol, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 May 27
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein. J Biol Chem (2019)
Garg A, Orru R, Ye W, Distler U, Chojnacki JE, Köhn M, Tenzer S, Sönnichsen C, Wolf E
RgGuinier 3.1 nm
Dmax 13.7 nm

SASDF67 – Complex of CBP KIX domain with BMAL1 (G490-L625) including C-terminal transactivation domain (TAD) (Mus musculus)

UniProt ID: P45481 (586-672) Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP)

UniProt ID: Q9WTL8-2 (490-625) Brain and muscle ARNT-like 1 (G490-L625) including transactivation domain (TAD)
Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP)Brain and muscle ARNT-like 1 (G490-L625) including transactivation domain (TAD) experimental SAS data
DAMMIN model
Sample: Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP) monomer, 10 kDa Mus musculus protein
Brain and muscle ARNT-like 1 (G490-L625) including transactivation domain (TAD) monomer, 14 kDa Mus musculus protein
Buffer: 25 mM Hepes, 150 NaCl, 1 mM DTT, 5% Glycerol, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 May 27
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein. J Biol Chem (2019)
Garg A, Orru R, Ye W, Distler U, Chojnacki JE, Köhn M, Tenzer S, Sönnichsen C, Wolf E
RgGuinier 3.8 nm
Dmax 17.5 nm

SASDF77 – Kinase-inducible domain interacting (KIX) domain of CREB-binding protein tethered to 1-10

UniProt ID: P45481 (586-672) Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C

UniProt ID: None (None-None) 1-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}-3-sulfanylpropan-1-one
Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C1-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}-3-sulfanylpropan-1-one experimental SAS data
DAMMIN model
Sample: Kinase-inducible domain interacting (KIX) domain of CREB-binding protein (CBP), mutation L664C monomer, 10 kDa Mus musculus protein
1-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}-3-sulfanylpropan-1-one monomer, 0 kDa
Buffer: 25 mM Hepes, 150 NaCl, 5% Glycerol, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 May 27
Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein. J Biol Chem (2019)
Garg A, Orru R, Ye W, Distler U, Chojnacki JE, Köhn M, Tenzer S, Sönnichsen C, Wolf E
RgGuinier 1.7 nm
Dmax 6.4 nm