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SASDNG8 – LARGE xylosyl- and glucuronyltransferase 1 (LARGE1dTM) dimer treated with PNGase F enzyme

Xylosyl- and glucuronyltransferase LARGE1 experimental SAS data
DAMMIF model
Sample: Xylosyl- and glucuronyltransferase LARGE1 dimer, 179 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Mar 18
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan. Nat Commun 16(1):9028 (2025)
Joseph S, Schnicker NJ, Spellmon N, Xu Z, Yan R, Yu Z, Davulcu O, Yang T, Hopkins J, Anderson ME, Venzke D, Campbell KP
RgGuinier 4.3 nm
Dmax 18.0 nm

SASDNH8 – Xylosyl- and glucuronyltransferase LARGE2 (LARGE2dTM) dimer

Xylosyl- and glucuronyltransferase LARGE2 experimental SAS data
DAMMIN model
Sample: Xylosyl- and glucuronyltransferase LARGE2 dimer, 168 kDa Mus musculus protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Mar 18
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan. Nat Commun 16(1):9028 (2025)
Joseph S, Schnicker NJ, Spellmon N, Xu Z, Yan R, Yu Z, Davulcu O, Yang T, Hopkins J, Anderson ME, Venzke D, Campbell KP
RgGuinier 4.2 nm
Dmax 16.5 nm

SASDNJ8 – Xylosyl- and glucuronyltransferase LARGE2 (LARGE2dTM) dimer treated with PNGase F enzyme

Xylosyl- and glucuronyltransferase LARGE2 experimental SAS data
DAMMIN model
Sample: Xylosyl- and glucuronyltransferase LARGE2 dimer, 168 kDa Mus musculus protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Mar 18
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan. Nat Commun 16(1):9028 (2025)
Joseph S, Schnicker NJ, Spellmon N, Xu Z, Yan R, Yu Z, Davulcu O, Yang T, Hopkins J, Anderson ME, Venzke D, Campbell KP
RgGuinier 4.1 nm
Dmax 15.9 nm
VolumePorod 231 nm3