Small Angle Scattering Biological Data Bank SASBDB

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SASDR28 – Human wild-type nicotinamide phosphoribosyltransferase (NAMPT) in the presence of nicotinamide

Nicotinamide phosphoribosyltransferase experimental SAS data

Nicotinamide phosphoribosyltransferase Kratky plot

Sample:	Nicotinamide phosphoribosyltransferase dimer, 114 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 500 mM NaCl, 6 mM MgCl2, 5% (v/v) glycerol, 1 mM nicotinamide, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 May 20

Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity. J Struct Biol :108004 (2023)
Houry D, Raasakka A, Ferrario E, Niere M, Bifulco E, Kursula P, Ziegler M

R_g^Guinier	3.2	nm
D_max	12.8	nm
Volume^Porod	166	nm³

SASDR38 – Human wild-type nicotinamide phosphoribosyltransferase (NAMPT) in the presence of nicotinic acid

Sample:	Nicotinamide phosphoribosyltransferase dimer, 114 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 500 mM NaCl, 6 mM MgCl2, 5% (v/v) glycerol, 1 mM nicotinic acid, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 May 20

R_g^Guinier	3.3	nm
D_max	12.9	nm
Volume^Porod	180	nm³

SASDR48 – Human wild-type nicotinamide phosphoribosyltransferase (NAMPT) in the presence of phosphoribosyl pyrophosphate

Sample:	Nicotinamide phosphoribosyltransferase dimer, 114 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 500 mM NaCl, 6 mM MgCl2, 5% (v/v) glycerol, 1 mM phosphoribosyl pyrophosphate, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 May 20

R_g^Guinier	3.3	nm
D_max	12.9	nm
Volume^Porod	173	nm³

SASDR58 – Human nicotinamide phosphoribosyltransferase Δ42-51 loop mutant (NAMPT Δ42-51)

Nicotinamide phosphoribosyltransferase Δ42-51 experimental SAS data

Nicotinamide phosphoribosyltransferase Δ42-51 Kratky plot

Sample:	Nicotinamide phosphoribosyltransferase Δ42-51 dimer, 111 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 500 mM NaCl, 6 mM MgCl2, 5% (v/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 May 20

R_g^Guinier	3.2	nm
D_max	11.0	nm
Volume^Porod	159	nm³

SASDR68 – Human nicotinamide phosphoribosyltransferase Δ42-51 loop mutant (NAMPT Δ42-51) in the presence of nicotinamide

Sample:	Nicotinamide phosphoribosyltransferase Δ42-51 dimer, 111 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 500 mM NaCl, 6 mM MgCl2, 5% (v/v) glycerol, 1 mM nicotinamide, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 May 20

R_g^Guinier	3.2	nm
D_max	10.9	nm
Volume^Porod	151	nm³

SASDR78 – Human nicotinamide phosphoribosyltransferase Δ42-51 loop mutant (NAMPT Δ42-51) in the presence of nicotinic acid

Sample:	Nicotinamide phosphoribosyltransferase Δ42-51 dimer, 111 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 500 mM NaCl, 6 mM MgCl2, 5% (v/v) glycerol, 1 mM nicotinic acid, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 May 20

R_g^Guinier	3.3	nm
D_max	11.2	nm
Volume^Porod	152	nm³

SASDR88 – Human nicotinamide phosphoribosyltransferase Δ42-51 loop mutant (NAMPT Δ42-51) in the presence of phosphoribosyl pyrophosphate

Sample:	Nicotinamide phosphoribosyltransferase Δ42-51 dimer, 111 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 500 mM NaCl, 6 mM MgCl2, 5% (v/v) glycerol, 1 mM phosphoribosyl pyrophosphate, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 May 20

R_g^Guinier	3.2	nm
D_max	11.4	nm
Volume^Porod	154	nm³

SASDM53 – RRM1-ZnF1-RRM2 triple domains of RNA-binding protein 5 (C191G mutant)

RNA Binding Motif protein 5 (I107T, C191G) experimental SAS data

RNA Binding Motif protein 5 (I107T, C191G) Kratky plot

Sample:	RNA Binding Motif protein 5 (I107T, C191G) monomer, 26 kDa Homo sapiens protein
Buffer:	20 mM MES, 400 mM NaCl, 1 mM DTT, pH: 6.5
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, SFB 1035, Technische Universität München on 2017 Feb 9

Structural basis for specific RNA recognition by the alternative splicing factor RBM5. Nat Commun 14(1):4233 (2023)
Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M

R_g^Guinier	2.3	nm
D_max	7.8	nm
Volume^Porod	36	nm³

SASDQK8 – G. gallus TRPV4 N-terminal Domain, deletion mutant ∆N104

Transient receptor potential cation channel subfamily V member 4 experimental SAS data

Transient receptor potential cation channel subfamily V member 4 Kratky plot

Sample:	Transient receptor potential cation channel subfamily V member 4 monomer, 32 kDa Gallus gallus protein
Buffer:	20 mM Tris, 300 mM NaCl, 10 mM DTT, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2020 Mar 16

Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity Nature Communications 14(1) (2023)
Goretzki B, Wiedemann C, McCray B, Schäfer S, Jansen J, Tebbe F, Mitrovic S, Nöth J, Cabezudo A, Donohue J, Jeffries C, Steinchen W, Stengel F, Sumner C, Hummer G, Hellmich U

R_g^Guinier	2.8	nm
D_max	13.0	nm
Volume^Porod	49	nm³

SASDQL8 – G. gallus TRPV4 N-terminal Domain, deletion mutant ∆N120

Sample:	Transient receptor potential cation channel subfamily V member 4 monomer, 29 kDa Gallus gallus protein
Buffer:	20 mM Tris, 300 mM NaCl, 10 mM DTT, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2020 Mar 16

R_g^Guinier	2.7	nm
D_max	12.5	nm
Volume^Porod	43	nm³

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