Browse by ORGANISM: Homo sapiens (Human)

SASDWR2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S kappa chain C214S mutant

Human immunoglobulin ChiLob 7/4 - kappa chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S experimental SAS data
Human immunoglobulin ChiLob 7/4 - kappa chain C214S Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S Kratky plot
Sample: Human immunoglobulin ChiLob 7/4 - kappa chain C214S dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 16.0 nm
VolumePorod 209 nm3

SASDWS2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S kappa chain C214S mutant

Human immunoglobulin ChiLob 7/4 - kappa chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S experimental SAS data
Human immunoglobulin ChiLob 7/4 - kappa chain C214S Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S Kratky plot
Sample: Human immunoglobulin ChiLob 7/4 - kappa chain C214S dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 15.3 nm
VolumePorod 204 nm3

SASDWT2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S kappa chain E123C/C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224SHuman immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S Human immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S dimer, 99 kDa Homo sapiens protein
Human immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S dimer, 47 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.8 nm
Dmax 15.1 nm
VolumePorod 205 nm3

SASDWU2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S mutant

Human immunoglobulin ChiLob 7/4 - kappa chainHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S experimental SAS data
Human immunoglobulin ChiLob 7/4 - kappa chain Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S Kratky plot
Sample: Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Nov 29
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 5.0 nm
Dmax 16.5 nm
VolumePorod 215 nm3

SASDWV2 – Human immunoglobulin gamma 1 (IgG1) SAP1.3

Human immunoglobulin gamma 1 (IgG1) SAP1.3 - heavy chainHuman immunoglobulin SAP1.3 - kappa chain experimental SAS data
Human immunoglobulin gamma 1 (IgG1) SAP1.3 - heavy chain Human immunoglobulin SAP1.3 - kappa chain Kratky plot
Sample: Human immunoglobulin gamma 1 (IgG1) SAP1.3 - heavy chain dimer, 99 kDa Homo sapiens protein
Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 5.2 nm
Dmax 16.8 nm
VolumePorod 229 nm3

SASDWW2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3

Human immunoglobulin SAP1.3 - kappa chainHuman immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain experimental SAS data
Human immunoglobulin SAP1.3 - kappa chain Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain Kratky plot
Sample: Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 15.9 nm
VolumePorod 214 nm3

SASDWX2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226SHuman immunoglobulin SAP1.3 - kappa chain C214S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S Human immunoglobulin SAP1.3 - kappa chain C214S Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S dimer, 99 kDa Homo sapiens protein
Human immunoglobulin SAP1.3 - kappa chain C214S dimer, 48 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 15.8 nm
VolumePorod 213 nm3

SASDWY2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S kappa chain C214S mutant

Human immunoglobulin SAP1.3 - kappa chain C214SHuman immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S experimental SAS data
Human immunoglobulin SAP1.3 - kappa chain C214S Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S Kratky plot
Sample: Human immunoglobulin SAP1.3 - kappa chain C214S dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C227S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 15.7 nm
VolumePorod 222 nm3

SASDWZ2 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S mutant

Human immunoglobulin SAP1.3 - kappa chainHuman immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S experimental SAS data
Human immunoglobulin SAP1.3 - kappa chain Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S Kratky plot
Sample: Human immunoglobulin SAP1.3 - kappa chain dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S/C227S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 5.0 nm
Dmax 15.8 nm
VolumePorod 222 nm3

SASDVA6 – Pentraxin-3

Pentraxin-related protein PTX3 experimental SAS data
ALLOSMOD model
Sample: Pentraxin-related protein PTX3 octamer, 321 kDa Homo sapiens protein
Buffer: 50 mM Tris-HCl, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at B21, Diamond Light Source on 2018 Sep 28
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Matrix Biology 136:52-68 (2025)
Shah A, Zhang X, Snee M, Lockhart-Cairns M, Levy C, Jowitt T, Birchenough H, Dean L, Collins R, Dodd R, Roberts A, Enghild J, Mantovani A, Fontana J, Baldock C, Inforzato A, Richter R, Day A
RgGuinier 8.6 nm
Dmax 43.1 nm
VolumePorod 658 nm3