Browse by ORGANISM: Homo sapiens (Human)

SASDVB6 – Pentraxin-3 truncation mutant lacking the first 24 amino acids per mature promoter

Pentraxin-related protein PTX3 (N-terminal deletion mutant) experimental SAS data
ALLOSMOD model
Sample: Pentraxin-related protein PTX3 (N-terminal deletion mutant) octamer, 301 kDa Homo sapiens protein
Buffer: 137 mM NaCl, 2.7 mM KCl, 10 mM phosphate buffer, pH: 7.4
Experiment: SAXS data collected at B21, Diamond Light Source on 2020 Feb 6
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Matrix Biology 136:52-68 (2025)
Shah A, Zhang X, Snee M, Lockhart-Cairns M, Levy C, Jowitt T, Birchenough H, Dean L, Collins R, Dodd R, Roberts A, Enghild J, Mantovani A, Fontana J, Baldock C, Inforzato A, Richter R, Day A
RgGuinier 8.4 nm
Dmax 40.0 nm
VolumePorod 647 nm3

SASDVC6 – Tetramer of Pentraxin-3

Pentraxin-related protein PTX3 (C317S, C318S) experimental SAS data
ALLOSMOD model
Sample: Pentraxin-related protein PTX3 (C317S, C318S) tetramer, 160 kDa Homo sapiens protein
Buffer: 137 mM NaCl, 2.7 mM KCl, 10 mM phosphate buffer, pH: 7.4
Experiment: SAXS data collected at B21, Diamond Light Source on 2020 Feb 6
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Matrix Biology 136:52-68 (2025)
Shah A, Zhang X, Snee M, Lockhart-Cairns M, Levy C, Jowitt T, Birchenough H, Dean L, Collins R, Dodd R, Roberts A, Enghild J, Mantovani A, Fontana J, Baldock C, Inforzato A, Richter R, Day A
RgGuinier 7.8 nm
Dmax 26.0 nm
VolumePorod 370 nm3

SASDVV6 – Extended single alpha-helix (SAH) region of Drebrin

Drebrin experimental SAS data
OTHER [STATIC IMAGE] model
Sample: Drebrin monomer, 10 kDa Homo sapiens protein
Buffer: 17 mM NaH2PO4, 3 mM Na2HPO4, 50 mM NaCl, pH: 6
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Jul 7
Dynamic Interchange of Local Residue-Residue Interactions in the Largely Extended Single Alpha-Helix in Drebrin Biochemical Journal (2025)
Varga S, Péterfia B, Dudola D, Farkas V, Jeffries C, Permi P, Gáspári Z
RgGuinier 3.0 nm
Dmax 12.0 nm
VolumePorod 18 nm3

SASDVZ8 – Pro-Trp-Trp-Pro (PWWP) domain from human DNA (cytosine-5)-methyltransferase 3B (DNMT3B)

DNA (cytosine-5)-methyltransferase 3B Pro-Trp-Trp-Pro (PWWP) domain experimental SAS data
GASBOR model
Sample: DNA (cytosine-5)-methyltransferase 3B Pro-Trp-Trp-Pro (PWWP) domain monomer, 17 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2024 Apr 20
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 1.8 nm
Dmax 6.4 nm
VolumePorod 20464 nm3

SASDV29 – Complex of human DNA methyltransferase 3 beta DNMT3B (215-853) and DNA methyltransferase 3-like DNMT3L (178-379)

DNA methyltransferase 3 beta (215-853)DNA methyltransferase 3-like (178-379) experimental SAS data
GASBOR model
Sample: DNA methyltransferase 3 beta (215-853) dimer, 145 kDa Homo sapiens protein
DNA methyltransferase 3-like (178-379) dimer, 47 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2021 Apr 16
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 5.2 nm
Dmax 21.2 nm
VolumePorod 271263 nm3

SASDVJ9 – Human DNA methyltransferase 3 beta DNMT3B (215-853) and DNA methyltransferase 3-like DNMT3L (178-379) in complex with histone H3

Histone H3.3DNA methyltransferase 3 beta (215-853) experimental SAS data
GASBOR model
Sample: Histone H3.3 dimer, 8 kDa Homo sapiens protein
DNA methyltransferase 3 beta (215-853) dimer, 145 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2021 Apr 16
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 5.1 nm
Dmax 18.9 nm
VolumePorod 275 nm3

SASDVK9 – Pro-Trp-Trp-Pro (PWWP) domain from human DNA (cytosine-5)-methyltransferase 3B (DNMT3B) in complex with histone H3

Histone H3.3DNA (cytosine-5)-methyltransferase 3B Pro-Trp-Trp-Pro (PWWP) domain experimental SAS data
GASBOR model
Sample: Histone H3.3 monomer, 4 kDa Homo sa protein
DNA (cytosine-5)-methyltransferase 3B Pro-Trp-Trp-Pro (PWWP) domain monomer, 17 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2024 Sep 17
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 1.8 nm
Dmax 7.4 nm
VolumePorod 19 nm3

SASDVL9 – Human DNA methyltransferase 3 beta DNMT3B (413-853) and DNA methyltransferase 3-like DNMT3L (178-379)

DNA methyltransferase 3-like (178-379)DNA methyltransferase 3 beta (413-853) experimental SAS data
GASBOR model
Sample: DNA methyltransferase 3-like (178-379) dimer, 47 kDa Homo sapiens protein
DNA methyltransferase 3 beta (413-853) dimer, 100 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2022 Nov 2
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 4.5 nm
Dmax 15.9 nm
VolumePorod 191 nm3

SASDVM9 – Human DNA methyltransferase 3 beta DNMT3B (413-853) and DNA methyltransferase 3-like DNMT3L (178-379) in complex with histone H3

Histone H3.3DNA methyltransferase 3-like (178-379)DNA methyltransferase 3 beta (413-853) experimental SAS data
GASBOR model
Sample: Histone H3.3 dimer, 8 kDa Homo sapiens protein
DNA methyltransferase 3-like (178-379) dimer, 47 kDa Homo sapiens protein
DNA methyltransferase 3 beta (413-853) dimer, 100 kDa Homo sapiens protein
Buffer: 20 mM Tris, 300 mM NaCl, 1 mM TCEP, 5% glycerol, pH: 8
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2022 Nov 2
Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation. Sci Adv 11(13):eadu8116 (2025)
Cho CC, Huang HH, Jiang BC, Yang WZ, Chen YN, Yuan HS
RgGuinier 4.5 nm
Dmax 16.0 nm
VolumePorod 186 nm3

SASDU23 – Heterochromatin protein HP1α, S97A mutant, full-length (HP1α_S97A) in 50 mM NaCl

Heterochromatin protein HP1α, S97A mutant, full-length experimental SAS data
Heterochromatin protein HP1α, S97A mutant, full-length Kratky plot
Sample: Heterochromatin protein HP1α, S97A mutant, full-length dimer, 41 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 50 mM NaCl, 1 mM DTT, pH: 7
Experiment: SAXS data collected at BL-10C, Photon Factory (PF), High Energy Accelerator Research Organization (KEK) on 2018 Jun 2
A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses Nucleic Acids Research 53(6) (2025)
Furukawa A, Yonezawa K, Negami T, Yoshimura Y, Hayashi A, Nakayama J, Adachi N, Senda T, Shimizu K, Terada T, Shimizu N, Nishimura Y
RgGuinier 4.0 nm
Dmax 14.4 nm
VolumePorod 117 nm3