SASDF73 – Bruton's Tyrosine Kinase - SH3-SH2-kinase domain

Bruton's tyrosine kinase - Src homology 3-2 kinase domain experimental SAS data
Bruton's Tyrosine Kinase - SH3-SH2-kinase domain Rg histogram
Sample: Bruton's tyrosine kinase - Src homology 3-2 kinase domain monomer, 52 kDa Homo sapiens protein
Buffer: 20mM Tris, 150mM NaCl, 1mM TCEP, 5% glycerol, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2018 Nov 2
Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms Nature Communications 11(1) (2020)
Duarte D, Lamontanara A, La Sala G, Jeong S, Sohn Y, Panjkovich A, Georgeon S, Kükenshöner T, Marcaida M, Pojer F, De Vivo M, Svergun D, Kim H, Dal Peraro M, Hantschel O
RgGuinier 2.6 nm
Dmax 8.3 nm
VolumePorod 72 nm3

SASDF83 – Bruton's Tyrosine Kinase - Full-length

Bruton's tyrosine kinase - full length experimental SAS data
Bruton's Tyrosine Kinase - Full-length Rg histogram
Sample: Bruton's tyrosine kinase - full length monomer, 77 kDa Homo sapiens protein
Buffer: 20mM Tris, 150mM NaCl, 1mM TCEP, 5% glycerol, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2018 Nov 3
Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms Nature Communications 11(1) (2020)
Duarte D, Lamontanara A, La Sala G, Jeong S, Sohn Y, Panjkovich A, Georgeon S, Kükenshöner T, Marcaida M, Pojer F, De Vivo M, Svergun D, Kim H, Dal Peraro M, Hantschel O
RgGuinier 4.0 nm
Dmax 15.6 nm
VolumePorod 114 nm3

SASDFA9 – Poly-adenosine rA30 in 20 mM NaCl

Poly-adenosine experimental SAS data
CUSTOM IN-HOUSE model
Sample: Poly-adenosine monomer, 10 kDa RNA
Buffer: 1 mM Na-MOPS, 20 mM NaCl, 20 µM EDTA, pH: 7
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2015 Oct 24
Visualizing disordered single-stranded RNA: connecting sequence, structure and electrostatics. J Am Chem Soc (2019)
Plumridge A, Andresen K, Pollack L
RgGuinier 2.7 nm
Dmax 11.0 nm
VolumePorod 17 nm3

SASDFB9 – Poly-adenosine rA30 in 100 mM NaCl

Poly-adenosine experimental SAS data
CUSTOM IN-HOUSE model
Sample: Poly-adenosine monomer, 10 kDa RNA
Buffer: 1 mM Na-MOPS, 100 mM NaCl, 20 µM EDTA, pH: 7
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2015 Oct 25
Visualizing disordered single-stranded RNA: connecting sequence, structure and electrostatics. J Am Chem Soc (2019)
Plumridge A, Andresen K, Pollack L
RgGuinier 2.4 nm
Dmax 10.7 nm
VolumePorod 14 nm3

SASDFC9 – Poly-adenosine rA30 in 200 mM NaCl

Poly-adenosine experimental SAS data
CUSTOM IN-HOUSE model
Sample: Poly-adenosine monomer, 10 kDa RNA
Buffer: 1 mM Na-MOPS, 200 mM NaCl, 20 µM EDTA, pH: 7
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2015 Oct 25
Visualizing disordered single-stranded RNA: connecting sequence, structure and electrostatics. J Am Chem Soc (2019)
Plumridge A, Andresen K, Pollack L
RgGuinier 2.5 nm
Dmax 10.5 nm
VolumePorod 14 nm3

SASDFD9 – Poly-adenosine rA30 in 400 mM NaCl

Poly-adenosine experimental SAS data
Poly-adenosine Kratky plot
Sample: Poly-adenosine monomer, 10 kDa RNA
Buffer: 1 mM Na-MOPS, 400 mM NaCl, 20 µM EDTA, pH: 7
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2015 Oct 25
Visualizing disordered single-stranded RNA: connecting sequence, structure and electrostatics. J Am Chem Soc (2019)
Plumridge A, Andresen K, Pollack L
RgGuinier 2.4 nm
Dmax 10.0 nm
VolumePorod 13 nm3

SASDFE9 – Poly-adenosine rA30 in 600 mM NaCl

Poly-adenosine experimental SAS data
Poly-adenosine Kratky plot
Sample: Poly-adenosine monomer, 10 kDa RNA
Buffer: 1 mM Na-MOPS, 600 mM NaCl, 20 µM EDTA, pH: 7
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2015 Oct 25
Visualizing disordered single-stranded RNA: connecting sequence, structure and electrostatics. J Am Chem Soc (2019)
Plumridge A, Andresen K, Pollack L
RgGuinier 2.2 nm
Dmax 10.2 nm
VolumePorod 13 nm3

SASDFF9 – Poly-adenosine rA30 in 1 mM MgCl2

Poly-adenosine experimental SAS data
CUSTOM IN-HOUSE model
Sample: Poly-adenosine monomer, 10 kDa RNA
Buffer: 1 mM Na-MOPS, 20 mM NaCl, 1 mM MgCl2, 20 µM EDTA, pH: 7
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2019 Jul 24
Visualizing disordered single-stranded RNA: connecting sequence, structure and electrostatics. J Am Chem Soc (2019)
Plumridge A, Andresen K, Pollack L
RgGuinier 2.5 nm
Dmax 10.4 nm
VolumePorod 12 nm3

SASDFG9 – Poly-adenosine rA30 in 2 mM MgCl2

Poly-adenosine experimental SAS data
CUSTOM IN-HOUSE model
Sample: Poly-adenosine monomer, 10 kDa RNA
Buffer: 1 mM Na-MOPS, 20 mM NaCl, 2 mM MgCl2, 20 µM EDTA, pH: 7
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2015 Oct 24
Visualizing disordered single-stranded RNA: connecting sequence, structure and electrostatics. J Am Chem Soc (2019)
Plumridge A, Andresen K, Pollack L
RgGuinier 2.4 nm
Dmax 10.0 nm
VolumePorod 12 nm3

SASDFH9 – Poly-adenosine rA30 in 5 mM MgCl2

Poly-adenosine experimental SAS data
Poly-adenosine Kratky plot
Sample: Poly-adenosine monomer, 10 kDa RNA
Buffer: 1 mM Na-MOPS, 20 mM NaCl, 5 mM MgCl2, 20µM EDTA, pH: 7
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2015 Oct 24
Visualizing disordered single-stranded RNA: connecting sequence, structure and electrostatics. J Am Chem Soc (2019)
Plumridge A, Andresen K, Pollack L
RgGuinier 2.3 nm
Dmax 10.0 nm
VolumePorod 15 nm3

4135 hits found.