SASDV56 – Microtubule-associated protein tau, lysine-rich four-repeat domain 4RD synthetically linked to Ubiquitin at tau residue C317

Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A)Polyubiquitin-B experimental SAS data
Microtubule-associated protein tau, lysine-rich four-repeat domain 4RD synthetically linked to Ubiquitin at tau residue C317 Rg histogram
Sample: Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A) monomer, 14 kDa Homo sapiens protein
Polyubiquitin-B monomer, 9 kDa Fukomys damarensis protein
Buffer: 100 mM NaCl, pH: 6.8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Mar 17
Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain. Proc Natl Acad Sci U S A 122(15):e2425831122 (2025)
Viola G, Trivellato D, Laitaoja M, Jänis J, Felli IC, D'Onofrio M, Mollica L, Giachin G, Assfalg M
RgGuinier 3.3 nm
Dmax 13.3 nm
VolumePorod 41 nm3

SASDV66 – Microtubule-associated protein tau, lysine-rich four-repeat domain 4RD synthetically linked to Ubiquitin at tau residue C353

Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A)Polyubiquitin-B experimental SAS data
Microtubule-associated protein tau, lysine-rich four-repeat domain 4RD synthetically linked to Ubiquitin at tau residue C353 Rg histogram
Sample: Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A) monomer, 14 kDa Homo sapiens protein
Polyubiquitin-B monomer, 9 kDa Fukomys damarensis protein
Buffer: 100 mM NaCl, pH: 6.8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Mar 17
Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain. Proc Natl Acad Sci U S A 122(15):e2425831122 (2025)
Viola G, Trivellato D, Laitaoja M, Jänis J, Felli IC, D'Onofrio M, Mollica L, Giachin G, Assfalg M
RgGuinier 3.1 nm
Dmax 12.1 nm
VolumePorod 33 nm3

SASDV76 – Microtubule-associated protein tau, lysine-rich four-repeat domain 4RD synthetically linked to two Ubiquitins at tau residues C311 and C317

Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A)Polyubiquitin-BPolyubiquitin-B experimental SAS data
Microtubule-associated protein tau, lysine-rich four-repeat domain 4RD synthetically linked to two Ubiquitins at tau residues C311 and C317 Rg histogram
Sample: Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A) monomer, 14 kDa Homo sapiens protein
Polyubiquitin-B monomer, 9 kDa Fukomys damarensis protein
Polyubiquitin-B monomer, 9 kDa Fukomys damarensis protein
Buffer: 100 mM NaCl, pH: 6.8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Mar 17
Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain. Proc Natl Acad Sci U S A 122(15):e2425831122 (2025)
Viola G, Trivellato D, Laitaoja M, Jänis J, Felli IC, D'Onofrio M, Mollica L, Giachin G, Assfalg M
RgGuinier 3.3 nm
Dmax 12.2 nm
VolumePorod 59 nm3

SASDUB8 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226SHuman immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain C214S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain C214S Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S dimer, 52 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain C214S dimer, 48 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Jun 8
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 3.8 nm
Dmax 12.9 nm
VolumePorod 130 nm3

SASDUC8 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C227S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C227SHuman immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain C214S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C227S Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain C214S Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C227S dimer, 52 kDa protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain C214S dimer, 48 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Jun 8
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 3.9 nm
Dmax 13.7 nm
VolumePorod 135 nm3

SASDUD8 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S/C227S mutant

Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S/C227SHuman immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain experimental SAS data
Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S/C227S Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain C226S/C227S dimer, 52 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain dimer, 48 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Jun 8
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.2 nm
Dmax 15.1 nm
VolumePorod 140 nm3

SASDUE8 – Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2

Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chainHuman immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain experimental SAS data
Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - kappa light chain dimer, 48 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) SAP1.3 F(ab')2 - heavy chain dimer, 52 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Jun 8
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 3.8 nm
Dmax 12.8 nm
VolumePorod 126 nm3

SASDUF8 – Human immunoglobulin gamma 1 (IgG1) SAP1.3 F(ab')2

Human immunoglobulin gamma 1 (IgG1) SAP1.3 F(ab')2 - heavy chainHuman immunoglobulin gamma 1 (IgG1) SAP1.3 F(ab')2 - kappa light chain experimental SAS data
Human immunoglobulin gamma 1 (IgG1) SAP1.3 F(ab')2 - heavy chain Human immunoglobulin gamma 1 (IgG1) SAP1.3 F(ab')2 - kappa light chain Kratky plot
Sample: Human immunoglobulin gamma 1 (IgG1) SAP1.3 F(ab')2 - heavy chain dimer, 51 kDa Homo sapiens protein
Human immunoglobulin gamma 1 (IgG1) SAP1.3 F(ab')2 - kappa light chain dimer, 48 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Jun 8
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.5 nm
Dmax 16.3 nm
VolumePorod 139 nm3

SASDUG8 – Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2

Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chainHuman immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain experimental SAS data
Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chain Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain Kratky plot
Sample: Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chain dimer, 51 kDa Homo sapiens protein
Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain dimer, 47 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Apr 12
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.6 nm
Dmax 17.4 nm
VolumePorod 133 nm3

SASDUH8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chainHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain experimental SAS data
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain dimer, 52 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain dimer, 47 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Jun 8
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 3.9 nm
Dmax 13.7 nm
VolumePorod 123 nm3

4690 hits found.