SASDUJ8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain experimental SAS data
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225S mutant Rg histogram
Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225S dimer, 52 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain dimer, 47 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Apr 12
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.2 nm
Dmax 14.8 nm
VolumePorod 127 nm3

SASDUK8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C225S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C225S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C225S kappa chain C214S mutant Rg histogram
Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214S dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C225S dimer, 52 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Apr 12
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.0 nm
Dmax 14.1 nm
VolumePorod 125 nm3

SASDUL8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S kappa chain C214S mutant Rg histogram
Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214S dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S dimer, 52 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2022 Apr 12
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 3.9 nm
Dmax 13.9 nm
VolumePorod 126 nm3

SASDWN2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chainHuman immunoglobulin ChiLob 7/4 - kappa chain experimental SAS data
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain Human immunoglobulin ChiLob 7/4 - kappa chain Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain dimer, 99 kDa Homo sapiens protein
Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 16.0 nm
VolumePorod 202 nm3

SASDWP2 – Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4

Human immunoglobulin ChiLob 7/4 - kappa chainHuman immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain experimental SAS data
Human immunoglobulin ChiLob 7/4 - kappa chain Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain Kratky plot
Sample: Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 5.1 nm
Dmax 16.6 nm
VolumePorod 214 nm3

SASDWQ2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224SHuman immunoglobulin ChiLob 7/4 - kappa chain C214S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S Human immunoglobulin ChiLob 7/4 - kappa chain C214S Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S dimer, 99 kDa Homo sapiens protein
Human immunoglobulin ChiLob 7/4 - kappa chain C214S dimer, 47 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 16.0 nm
VolumePorod 204 nm3

SASDWR2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S kappa chain C214S mutant

Human immunoglobulin ChiLob 7/4 - kappa chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S experimental SAS data
Human immunoglobulin ChiLob 7/4 - kappa chain C214S Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S Kratky plot
Sample: Human immunoglobulin ChiLob 7/4 - kappa chain C214S dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 16.0 nm
VolumePorod 209 nm3

SASDWS2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S kappa chain C214S mutant

Human immunoglobulin ChiLob 7/4 - kappa chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S experimental SAS data
Human immunoglobulin ChiLob 7/4 - kappa chain C214S Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S Kratky plot
Sample: Human immunoglobulin ChiLob 7/4 - kappa chain C214S dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.9 nm
Dmax 15.3 nm
VolumePorod 204 nm3

SASDWT2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S kappa chain E123C/C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224SHuman immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S experimental SAS data
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S Human immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S Kratky plot
Sample: Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S dimer, 99 kDa Homo sapiens protein
Human immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S dimer, 47 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Sep 28
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 4.8 nm
Dmax 15.1 nm
VolumePorod 205 nm3

SASDWU2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S mutant

Human immunoglobulin ChiLob 7/4 - kappa chainHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S experimental SAS data
Human immunoglobulin ChiLob 7/4 - kappa chain Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S Kratky plot
Sample: Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein
Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S dimer, 99 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2024 Nov 29
Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I
RgGuinier 5.0 nm
Dmax 16.5 nm
VolumePorod 215 nm3

4690 hits found.