Small Angle Scattering Biological Data Bank SASBDB

SASDEP8 – Intracellular region of the human Cyclin and CBS domain divalent metal cation transport mediator-4 in complex with Phosphatase of Regenerating Liver-1

CNNM4_BAT-cNMP-CtailProtein tyrosine phosphatase type IVA 1 experimental SAS data

Sample:	CNNM4_BAT-cNMP-Ctail dimer, 96 kDa Homo sapiens protein Protein tyrosine phosphatase type IVA 1 dimer, 40 kDa Mus musculus protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Aug 2

Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4. Int J Mol Sci 20(24) (2019)
Giménez-Mascarell P, Oyenarte I, González-Recio I, Fernández-Rodríguez C, Corral-Rodríguez MÁ, Campos-Zarraga I, Simón J, Kostantin E, Hardy S, Díaz Quintana A, Zubillaga Lizeaga M, Merino N, Diercks ...

R_g^Guinier	4.7	nm
D_max	18.5	nm
Volume^Porod	226	nm³

SASDEQ8 – Intracellular region of the human Cyclin and CBS domain divalent metal cation transport mediator-4

CNNM4_BAT-cNMP-Ctail experimental SAS data

Sample:	CNNM4_BAT-cNMP-Ctail dimer, 96 kDa Homo sapiens protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Aug 2

R_g^Guinier	4.0	nm
D_max	16.6	nm
Volume^Porod	156	nm³

SASDER8 – Cyclic nucleotide homology domain of the human Cyclin and CBS domain divalent metal cation transport mediator-4

Sample:	CNNM4_cNMP dimer, 42 kDa Homo sapiens protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Feb 7

R_g^Guinier	2.6	nm
D_max	9.7	nm
Volume^Porod	102	nm³

SASDES8 – Intracellular region of the human Cyclin and CBS domain divalent metal cation transport mediator-4 in complex with MgATP

Sample:	CNNM4_BAT-cNMP-Ctail dimer, 96 kDa Homo sapiens protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Sep 17

R_g^Guinier	3.9	nm
D_max	14.3	nm
Volume^Porod	149	nm³

SASDGD2 – Putative mitochondrial transferase CAF17: human IBA57

Putative transferase CAF17, mitochondrial experimental SAS data

Sample:	Putative transferase CAF17, mitochondrial monomer, 33 kDa Homo sapiens protein
Buffer:	50 mM phosphate, 150 mM NaCl, 5 mM DTT, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2018 Jul 10

Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery Scientific Reports 9(1) (2019)
Nasta V, Da Vela S, Gourdoupis S, Ciofi-Baffoni S, Svergun D, Banci L

R_g^Guinier	2.2	nm
D_max	7.1	nm
Volume^Porod	50	nm³

SASDGE2 – Human mitochondrial iron-sulfur cluster assembly ISCA2 protein

Iron-sulfur cluster assembly 2 homolog, mitochondrial experimental SAS data

Sample:	Iron-sulfur cluster assembly 2 homolog, mitochondrial dimer, 24 kDa Homo sapiens protein
Buffer:	50 mM phosphate, 150 mM NaCl, 5 mM DTT, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2018 Sep 16

R_g^Guinier	2.0	nm
D_max	6.7	nm
Volume^Porod	31	nm³

SASDGF2 – Putative mitochondrial transferase CAF17 bound to mitochondrial iron-sulfur cluster assembly ISCA2 protein (human IBA57-ISCA2 complex)

Putative transferase CAF17, mitochondrialIron-sulfur cluster assembly 2 homolog, mitochondrial experimental SAS data

Sample:	Putative transferase CAF17, mitochondrial monomer, 33 kDa Homo sapiens protein Iron-sulfur cluster assembly 2 homolog, mitochondrial dimer, 24 kDa Homo sapiens protein
Buffer:	50 mM phosphate, 150 mM NaCl, 5 mM DTT, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2018 Nov 22

R_g^Guinier	4.0	nm
D_max	16.4	nm
Volume^Porod	114	nm³

SASDF53 – Bruton's Tyrosine Kinase - kinase domain

Bruton's tyrosine kinase, kinase domain experimental SAS data

Sample:	Bruton's tyrosine kinase, kinase domain monomer, 32 kDa Homo sapiens protein
Buffer:	20mM Tris, 150mM NaCl, 1mM TCEP, 5% glycerol, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 May 11

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms Nature Communications 11(1) (2020)
Duarte D, Lamontanara A, La Sala G, Jeong S, Sohn Y, Panjkovich A, Georgeon S, Kükenshöner T, Marcaida M, Pojer F, De Vivo M, Svergun D, Kim H, Dal Peraro M, Hantschel O

R_g^Guinier	2.1	nm
D_max	6.8	nm
Volume^Porod	52	nm³

SASDF63 – Bruton's Tyrosine Kinase - SH2-kinase domain

Bruton's tyrosine kinase - Src homolgy domain 2 - kinase domain experimental SAS data

Bruton's Tyrosine Kinase - SH2-kinase domain Rg histogram

Sample:	Bruton's tyrosine kinase - Src homolgy domain 2 - kinase domain monomer, 46 kDa Homo sapiens protein
Buffer:	20mM Tris, 150mM NaCl, 1mM TCEP, 5% glycerol, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Nov 3

R_g^Guinier	2.8	nm
D_max	9.4	nm
Volume^Porod	64	nm³

SASDF73 – Bruton's Tyrosine Kinase - SH3-SH2-kinase domain

Bruton's tyrosine kinase - Src homology 3-2 kinase domain experimental SAS data

Bruton's Tyrosine Kinase - SH3-SH2-kinase domain Rg histogram

Sample:	Bruton's tyrosine kinase - Src homology 3-2 kinase domain monomer, 52 kDa Homo sapiens protein
Buffer:	20mM Tris, 150mM NaCl, 1mM TCEP, 5% glycerol, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Nov 2

R_g^Guinier	2.6	nm
D_max	8.3	nm
Volume^Porod	72	nm³

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