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Intramolecular Structural Heterogeneity altered by Long-range Contacts in an Intrinsically Disordered Protein
Sagi Meir
Submitted to SASBDB: 2023 May 22
Published in SASBDB:
2023 May 22
SASDS93
– Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDSA3
– Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDSB3
– Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDSC3
– Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
house mouse
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.1
nm
SASDSD3
– Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDSE3
– Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.0
nm
SASDSF3
– Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDSG3
– Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.1
nm
SASDSH3
– Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDSJ3
– Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.1
nm
SASDSK3
– Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDSL3
– Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDSM3
– Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDSN3
– Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 1 M NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDSP3
– Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(26-45) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDSQ3
– Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.3
nm
SASDSR3
– Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDSS3
– Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.3
nm
SASDST3
– Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 1 M NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDSU3
– Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(45-64) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.3
nm
SASDSV3
– Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDSW3
– Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.3
nm
SASDSX3
– Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.3
nm
SASDSY3
– Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 1 M NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.3
nm
SASDSZ3
– Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(67-86) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDS24
– Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
house mouse
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDS34
– Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
house mouse
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDS44
– Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
house mouse
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDS54
– Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
house mouse
protein
Buffer:
20 mM Tris, 1 M NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDS64
– Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(66-81) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
house mouse
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDS74
– Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDS84
– Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDS94
– Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Sep 15
R
g
Guinier
1.3
nm
SASDSA4
– Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(87-105) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDSB4
– Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDSC4
– Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDSD4
– Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDSE4
– Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 1 M NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDSF4
– Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(82-96) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.1
nm
SASDSG4
– Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDSH4
– Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDSJ4
– Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDSK4
– Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(106-128) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDSL4
– Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.2
nm
SASDSM4
– Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDSN4
– Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDSP4
– Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 1 M NaCl, pH: 8
Experiment:
SAXS data collected at B21, Diamond Light Source
on 2021 Sep 15
R
g
Guinier
1.1
nm
SASDSQ4
– Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(110-125) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm
SASDSR4
– Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDSS4
– Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDST4
– Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDSU4
– Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(129-146) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.3
nm
SASDSV4
– Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 50 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.0
nm
SASDSW4
– Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 150 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.1
nm
SASDSX4
– Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 500 mM NaCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.1
nm
SASDSY4
– Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain
Sample:
Segment S(130-143) of the Neurofilament low intrinsically disordered tail domain monomer, 2 kDa
Mus musculus
protein
Buffer:
20 mM Tris, 3 M GdnHCl, pH: 8
Experiment:
SAXS data collected at EMBL P12, PETRA III, DESY
on 2021 Apr 20
R
g
Guinier
1.2
nm