cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity.

Liu H, Moura-Alves P, Pei G, Mollenkopf HJ, Hurwitz R, Wu X, Wang F, Liu S, Ma M, Fei Y, Zhu C, Koehler AB, Oberbeck-Mueller D, Hahnke K, Klemm M, Guhlich-Bornhof U, Ge B, Tuukkanen A, Kolbe M, Dorhoi A, Kaufmann SH
EMBO Rep (2019 Mar 14)

PMID: 30872316 doi: 10.15252/embr.201846293

Submitted to SASBDB: 2019 Jan 14 Published in SASBDB: 2019 Mar 20

SASDEP9 – Cyclic GMP-AMP synthase (cGAS) Sample: Cyclic GMP-AMP synthase monomer, 61 kDa Homo sapiens protein Buffer: 20 mM HEPES, pH: 7.4 Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 Apr 25 RgGuinier 3.1 nm Dmax 12.7 nm VolumePorod 110 nm3

SASDEQ9 – Cyclic GMP-AMP synthase (cGAS) with cyclic guanosine monophosphate–adenosine monophosphate (2'3'-cGAMP) Sample: Cyclic GMP-AMP synthase dimer, 123 kDa Homo sapiens protein 2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine dimer, 1 kDa Buffer: 20 mM HEPES, pH: 7.4 Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 Apr 25 RgGuinier 3.9 nm Dmax 14.1 nm VolumePorod 127 nm3