Small Angle Scattering Biological Data Bank SASBDB

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40 hits found for Noureddine

SASDZJ4 – Alpha-actinin-2 (ACTN2) wild-type, SEC-SAXS (aggregate peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. Nat Commun 17(1) (2026)
Noureddine M, Mikolajek H, Cowieson N, Pinotsis N, Robinson P, Slater A, Redwood C, Loughna S, Denning C, Mohammed F, Gehmlich K

R_g^Guinier	12.1	nm
D_max	40.6	nm

SASDZK4 – Alpha-actinin-2 (ACTN2) wild-type, SEC-SAXS (dimer peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.9	nm
D_max	36.2	nm

SASDZL4 – ACTN2-R457C at 60 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.9	nm
D_max	37.0	nm

SASDZM4 – ACTN2-R457C at 53 degrees (°C) using batch-mode SAX

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.3	nm
D_max	35.3	nm

SASDZN4 – ACTN2-R457C at 40 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.3	nm
D_max	37.0	nm

SASDZP4 – ACTN2-E448A at 60 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.9	nm
D_max	36.9	nm

SASDZQ4 – ACTN2-E448A at 53 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.6	nm
D_max	36.0	nm

SASDZR4 – ACTN2-E448A at 40 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.1	nm
D_max	38.0	nm

SASDZS4 – ACTN2-R327C at 60 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.7	nm
D_max	34.0	nm

SASDZT4 – ACTN2-R327C at 53 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.4	nm
D_max	36.0	nm

SASDZU4 – ACTN2-R327C at 40 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.4	nm
D_max	37.0	nm

SASDZV4 – ACTN2-T247M at 60 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	19.1	nm
D_max	70.2	nm

SASDZW4 – ACTN2-T247M at 53 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	17.0	nm
D_max	67.0	nm

SASDZX4 – ACTN2-T247M at 40 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	12.0	nm
D_max	37.9	nm

SASDZY4 – ACTN2-G111V at 60 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	17.9	nm
D_max	87.0	nm

SASDZZ4 – ACTN2-G111V at 53 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	13.9	nm
D_max	43.0	nm

SASDZ25 – ACTN2-G111V at 40 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	12.3	nm
D_max	38.6	nm

SASDZ35 – ACTN2-R93Q at 60 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	14.0	nm
D_max	49.3	nm

SASDZ45 – ACTN2-R93Q at 53 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.6	nm
D_max	36.0	nm

SASDZ55 – ACTN2-R93Q at 40 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.1	nm
D_max	37.1	nm

SASDZ65 – ACTN2-M92V at 60 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	13.5	nm
D_max	46.8	nm

SASDZ75 – ACTN2-M92V at 53 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.6	nm
D_max	35.0	nm

SASDZ85 – ACTN2-M92V at 40 degrees (°C) using batch-mode SAXS

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.6	nm
D_max	38.3	nm

SASDZ95 – Alpha-actinin-2 (ACTN2) wild-type at 60 °C

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.2	nm
D_max	37.0	nm

SASDZA5 – Alpha-actinin-2 (ACTN2) wild-type at 53 °C

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.4	nm
D_max	37.7	nm

SASDZB5 – Alpha-actinin-2 (ACTN2) wild-type at 40 °C

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.2	nm
D_max	37.6	nm

SASDZC5 – ACTN2-R457C using SEC-SAXS (dimer peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.1	nm
D_max	37.0	nm

SASDZD5 – ACTN2-E448A using SEC-SAXS (dimer peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.8	nm
D_max	36.5	nm

SASDZE5 – ACTN2-R457C using SEC-SAXS (aggregate peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	12.8	nm
D_max	49.9	nm

SASDZF5 – ACTN2-E448A using SEC-SAXS (aggregate peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	13.9	nm
D_max	48.1	nm

SASDZG5 – ACTN2-R327C using SEC-SAXS (dimer peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.8	nm
D_max	36.1	nm

SASDZH5 – ACTN2-R327C using SEC-SAXS (aggregate peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	12.8	nm
D_max	49.1	nm

SASDZJ5 – ACTN2-T247M using SEC-SAXS (dimer peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.6	nm
D_max	37.0	nm

SASDZK5 – ACTN2-T247M using SEC-SAXS (aggregate peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	16.1	nm
D_max	78.0	nm

SASDZL5 – ACTN2-G111V using SEC-SAXS (dimer peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	10.4	nm
D_max	37.0	nm

SASDZM5 – ACTN2-G111V using SEC-SAXS (aggregate peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	13.0	nm
D_max	55.5	nm

SASDZN5 – ACTN2-R93Q using SEC-SAXS (dimer peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.6	nm
D_max	37.0	nm

SASDZP5 – ACTN2-R93Q using SEC-SAXS (aggregate peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	12.9	nm
D_max	57.0	nm

SASDZQ5 – ACTN2-M92V using SEC-SAXS (dimer peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.5	nm
D_max	36.1	nm

SASDZR5 – Alpha-actinin-2 (ACTN2) M92V variant, SEC-SAXS (aggregate peak)

Sample:	Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2024 May 13

R_g^Guinier	11.6	nm
D_max	49.0	nm