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40 hits found for Alpha-actinin-2

SASDZJ4 – Alpha-actinin-2 (ACTN2) wild-type, SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 12.1 nm
Dmax 40.6 nm

SASDZK4 – Alpha-actinin-2 (ACTN2) wild-type, SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.9 nm
Dmax 36.2 nm

SASDZL4 – ACTN2-R457C at 60 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.9 nm
Dmax 37.0 nm

SASDZM4 – ACTN2-R457C at 53 degrees (°C) using batch-mode SAX

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.3 nm
Dmax 35.3 nm

SASDZN4 – ACTN2-R457C at 40 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.3 nm
Dmax 37.0 nm

SASDZP4 – ACTN2-E448A at 60 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.9 nm
Dmax 36.9 nm

SASDZQ4 – ACTN2-E448A at 53 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.6 nm
Dmax 36.0 nm

SASDZR4 – ACTN2-E448A at 40 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.1 nm
Dmax 38.0 nm

SASDZS4 – ACTN2-R327C at 60 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.7 nm
Dmax 34.0 nm

SASDZT4 – ACTN2-R327C at 53 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.4 nm
Dmax 36.0 nm

SASDZU4 – ACTN2-R327C at 40 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.4 nm
Dmax 37.0 nm

SASDZV4 – ACTN2-T247M at 60 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 19.1 nm
Dmax 70.2 nm

SASDZW4 – ACTN2-T247M at 53 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 17.0 nm
Dmax 67.0 nm

SASDZX4 – ACTN2-T247M at 40 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 12.0 nm
Dmax 37.9 nm

SASDZY4 – ACTN2-G111V at 60 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 17.9 nm
Dmax 87.0 nm

SASDZZ4 – ACTN2-G111V at 53 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 13.9 nm
Dmax 43.0 nm

SASDZ25 – ACTN2-G111V at 40 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 12.3 nm
Dmax 38.6 nm

SASDZ35 – ACTN2-R93Q at 60 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 14.0 nm
Dmax 49.3 nm

SASDZ45 – ACTN2-R93Q at 53 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.6 nm
Dmax 36.0 nm

SASDZ55 – ACTN2-R93Q at 40 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.1 nm
Dmax 37.1 nm

SASDZ65 – ACTN2-M92V at 60 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 13.5 nm
Dmax 46.8 nm

SASDZ75 – ACTN2-M92V at 53 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.6 nm
Dmax 35.0 nm

SASDZ85 – ACTN2-M92V at 40 degrees (°C) using batch-mode SAXS

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.6 nm
Dmax 38.3 nm

SASDZ95 – Alpha-actinin-2 (ACTN2) wild-type at 60 °C

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.2 nm
Dmax 37.0 nm

SASDZA5 – Alpha-actinin-2 (ACTN2) wild-type at 53 °C

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.4 nm
Dmax 37.7 nm

SASDZB5 – Alpha-actinin-2 (ACTN2) wild-type at 40 °C

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.2 nm
Dmax 37.6 nm

SASDZC5 – ACTN2-R457C using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.1 nm
Dmax 37.0 nm

SASDZD5 – ACTN2-E448A using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.8 nm
Dmax 36.5 nm

SASDZE5 – ACTN2-R457C using SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 12.8 nm
Dmax 49.9 nm

SASDZF5 – ACTN2-E448A using SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 13.9 nm
Dmax 48.1 nm

SASDZG5 – ACTN2-R327C using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.8 nm
Dmax 36.1 nm

SASDZH5 – ACTN2-R327C using SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 12.8 nm
Dmax 49.1 nm

SASDZJ5 – ACTN2-T247M using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.6 nm
Dmax 37.0 nm

SASDZK5 – ACTN2-T247M using SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 16.1 nm
Dmax 78.0 nm

SASDZL5 – ACTN2-G111V using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 10.4 nm
Dmax 37.0 nm

SASDZM5 – ACTN2-G111V using SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 13.0 nm
Dmax 55.5 nm

SASDZN5 – ACTN2-R93Q using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.6 nm
Dmax 37.0 nm

SASDZP5 – ACTN2-R93Q using SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 12.9 nm
Dmax 57.0 nm

SASDZQ5 – ACTN2-M92V using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.5 nm
Dmax 36.1 nm

SASDZR5 – Alpha-actinin-2 (ACTN2) M92V variant, SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.6 nm
Dmax 49.0 nm