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SASDWG6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the third and fourth BRC repeats (BRC3-4) at 1 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 3-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 3-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 3-4) monomer, 16 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 4.5 nm
Dmax 18.0 nm
VolumePorod 140 nm3

SASDWH6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the third and fourth BRC repeats (BRC3-4) at 2 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 3-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 3-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 3-4) monomer, 16 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 4.6 nm
Dmax 18.3 nm
VolumePorod 148 nm3

SASDWJ6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first and the second BRC repeats (BRC1-2) SEC-SAXS

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 1-2) experimental SAS data
ALPHAFOLD model
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeats 1-2) monomer, 28 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 1 mM DTT, 2% sucrose, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 5.3 nm
Dmax 21.0 nm
VolumePorod 165 nm3

SASDWK6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first and the second BRC repeats (BRC1-2) at 0.5 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 1-2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 1-2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeats 1-2) monomer, 28 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 5.7 nm
Dmax 24.0 nm
VolumePorod 249 nm3

SASDWL6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first and the second BRC repeats (BRC1-2) at 1 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 1-2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 1-2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeats 1-2) monomer, 28 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 5.5 nm
Dmax 21.0 nm
VolumePorod 208 nm3

SASDWM6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first and the second BRC repeats (BRC1-2) at 2 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 1-2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 1-2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeats 1-2) monomer, 28 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 5.5 nm
Dmax 23.0 nm
VolumePorod 191 nm3

SASDWN6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first, second, third and fourth BRC repeats (BRC1-4) SEC-SAXS

Breast cancer type 2 susceptibility protein (BRC repeats 1-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
ALPHAFOLD model
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 1-4) monomer, 62 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) tetramer, 148 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 100 mM Li₂SO₄, 1 mM DTT, 1% sucrose, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 7.7 nm
Dmax 34.0 nm
VolumePorod 409 nm3

SASDWP6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first, second, third and fourth BRC repeats (BRC1-4) at 0.5 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 1-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 1-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 1-4) monomer, 62 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) tetramer, 148 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 8.1 nm
Dmax 33.0 nm
VolumePorod 422 nm3

SASDWQ6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first, second, third and fourth BRC repeats (BRC1-4) at 0.98 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 1-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 1-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 1-4) monomer, 62 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) tetramer, 148 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 7.6 nm
Dmax 33.3 nm
VolumePorod 392 nm3

SASDWR6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first, second, third and fourth BRC repeats (BRC1-4) at 2 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 1-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 1-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 1-4) monomer, 62 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) tetramer, 148 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 7.7 nm
Dmax 33.0 nm
VolumePorod 417 nm3