Browse by DISSEMINATION: Published

SASDW66 – RAD51 [F86E, A89E] in complex with second BRC repeat (BRC2) at 0.5 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeat 2) monomer, 4 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 2.6 nm
Dmax 9.5 nm
VolumePorod 83 nm3

SASDW76 – RAD51 [F86E, A89E] in complex with second BRC repeat (BRC2) at 1 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeat 2) monomer, 4 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 2.7 nm
Dmax 9.6 nm
VolumePorod 63 nm3

SASDW86 – RAD51 [F86E, A89E] in complex with second BRC repeat (BRC2) at 2 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeat 2) monomer, 4 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 2.7 nm
Dmax 9.8 nm
VolumePorod 69 nm3

SASDW96 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second and the third BRC repeats (BRC2-3) SEC-SAXS

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 2-3) experimental SAS data
ALPHAFOLD model
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeats 2-3) monomer, 28 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 100 mM Li₂SO₄, 1 mM DTT, 1% sucrose, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 5.5 nm
Dmax 23.0 nm
VolumePorod 167 nm3

SASDWA6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second and the third BRC repeats (BRC2-3) at 0.5 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 2-3) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 2-3) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeats 2-3) monomer, 28 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 6.0 nm
Dmax 21.0 nm
VolumePorod 236 nm3

SASDWB6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second and the third BRC repeats (BRC2-3) at 1 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 2-3) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 2-3) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeats 2-3) monomer, 28 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 5.7 nm
Dmax 23.0 nm
VolumePorod 225 nm3

SASDWC6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second and the third BRC repeats (BRC2-3) at 2 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 2-3) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 2-3) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Breast cancer type 2 susceptibility protein (BRC repeats 2-3) monomer, 28 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 5.7 nm
Dmax 22.0 nm
VolumePorod 167 nm3

SASDWD6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second, third and fourth BRC repeats (BRC2-4) SEC-SAXS

Breast cancer type 2 susceptibility protein (BRC repeats 2-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
ALPHAFOLD model
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 2-4) monomer, 39 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) trimer, 111 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 100 mM Li₂SO₄, 1 mM DTT, 1% sucrose, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 6.7 nm
Dmax 28.0 nm
VolumePorod 259 nm3

SASDWE6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the third and fourth BRC repeats (BRC3-4) SEC-SAXS

Breast cancer type 2 susceptibility protein (BRC repeats 3-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
ALPHAFOLD model
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 3-4) monomer, 16 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 1 mM DTT, 2% sucrose, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 4.6 nm
Dmax 18.0 nm
VolumePorod 142 nm3

SASDWF6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the third and fourth BRC repeats (BRC3-4) at 0.5 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 3-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 3-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: Breast cancer type 2 susceptibility protein (BRC repeats 3-4) monomer, 16 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Buffer: 20 mM K₂HPO₄/KH₂PO₄, 100 mM NaCl, 200 mM Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
Rinaldi F, Franco P, Veronesi M, Romeo E, Bresciani V, Varignani G, Catalano F, Bernetti M, Masetti M, Langer J, Girotto S, Cavalli A
RgGuinier 4.6 nm
Dmax 18.5 nm
VolumePorod 175 nm3