Browse by MODEL: Ensemble

SASDQY9 – Beclin-1 amino acids 1-150 with cysteine motif residues mutated to serine, along with a C-terminal tyrosine

Beclin-1 (C18S, C21S, A103V, C137S, C140S) experimental SAS data
Beclin-1 amino acids 1-150 with cysteine motif residues mutated to serine, along with a C-terminal tyrosine Rg histogram
Sample: Beclin-1 (C18S, C21S, A103V, C137S, C140S) monomer, 17 kDa Homo sapiens protein
Buffer: 50 mM Tris, 300 mM NaCl, pH: 8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 12
Invariant BECN1 CXXC motifs bind Zn(2+) and regulate structure and function of the BECN1 intrinsically disordered region. Autophagy :1-17 (2023)
Mukhopadhyay S, Subedi S, Hopkins JB, Ugrinov A, Chakravarthy S, Colbert CL, Sinha SC
RgGuinier 4.1 nm
Dmax 19.3 nm
VolumePorod 57 nm3

SASDNB8 – Mature full length human prion protein

Major prion protein experimental SAS data
Mature full length human prion protein Rg histogram
Sample: Major prion protein monomer, 23 kDa Homo sapiens protein
Buffer: 10 mM HEPES 100 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13
A tetracationic porphyrin with dual anti-prion activity. iScience 26(9):107480 (2023)
Masone A, Zucchelli C, Caruso E, Lavigna G, Eraña H, Giachin G, Tapella L, Comerio L, Restelli E, Raimondi I, Elezgarai SR, De Leo F, Quilici G, Taiarol L, Oldrati M, Lorenzo NL, García-Martínez S, Cagnotto A, Lucchetti J, Gobbi M, Vanni I, Nonno R, Di Bari MA, Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R
RgGuinier 2.8 nm
Dmax 10.2 nm

SASDNC8 – Mature full length human prion protein in the presence of zinc-tetracationic porphyrin [Zn(II)-BnPyP]

Major prion protein experimental SAS data
Mature full length human prion protein in the presence of zinc-tetracationic porphyrin [Zn(II)-BnPyP] Rg histogram
Sample: Major prion protein monomer, 23 kDa Homo sapiens protein
Buffer: 10 mM HEPES 100 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13
A tetracationic porphyrin with dual anti-prion activity. iScience 26(9):107480 (2023)
Masone A, Zucchelli C, Caruso E, Lavigna G, Eraña H, Giachin G, Tapella L, Comerio L, Restelli E, Raimondi I, Elezgarai SR, De Leo F, Quilici G, Taiarol L, Oldrati M, Lorenzo NL, García-Martínez S, Cagnotto A, Lucchetti J, Gobbi M, Vanni I, Nonno R, Di Bari MA, Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R
RgGuinier 3.1 nm
Dmax 11.3 nm

SASDND8 – Mature full length human prion protein in the presence of a cationic Fe(III) porphyrin [Fe(III)-TMPyP]

Major prion protein experimental SAS data
Mature full length human prion protein in the presence of a cationic Fe(III) porphyrin [Fe(III)-TMPyP] Rg histogram
Sample: Major prion protein monomer, 23 kDa Homo sapiens protein
Buffer: 10 mM HEPES 100 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13
A tetracationic porphyrin with dual anti-prion activity. iScience 26(9):107480 (2023)
Masone A, Zucchelli C, Caruso E, Lavigna G, Eraña H, Giachin G, Tapella L, Comerio L, Restelli E, Raimondi I, Elezgarai SR, De Leo F, Quilici G, Taiarol L, Oldrati M, Lorenzo NL, García-Martínez S, Cagnotto A, Lucchetti J, Gobbi M, Vanni I, Nonno R, Di Bari MA, Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R
RgGuinier 2.8 nm
Dmax 10.3 nm

SASDM65 – Candida albicans Ras-like protein 1

Ras-like protein 1 experimental SAS data
Candida albicans Ras-like protein 1 Rg histogram
Sample: Ras-like protein 1 monomer, 33 kDa Candida albicans protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 5% glycerol, 3 mM DTT, 5 mM MgCl2, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 3.6 nm
Dmax 15.1 nm
VolumePorod 56 nm3

SASDM95 – Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25

Ras-like protein 1Cell division control protein 25 experimental SAS data
Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25 Rg histogram
Sample: Ras-like protein 1 monomer, 33 kDa Candida albicans protein
Cell division control protein 25 monomer, 55 kDa Candida albicans (strain … protein
Buffer: 20 mM Na-phosphate, 150 mM NaCl, 1 mM EDTA, 5% glycerol, 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 4.0 nm
Dmax 17.7 nm
VolumePorod 149 nm3

SASDQR4 – Escherichia coli 6S RNA

6S RNA (SsrS gene) experimental SAS data
Escherichia coli 6S RNA Rg histogram
Sample: 6S RNA (SsrS gene) monomer, 59 kDa Escherichia coli RNA
Buffer: 20 mM Tris-HCl, 200 mM KCl, 5 mM MgCl2, pH: 8
Experiment: SAXS data collected at SWING, SOLEIL on 2016 Apr 4
Probing the conformational changes of in vivo overexpressed cell cycle regulator 6S ncRNA Frontiers in Molecular Biosciences 10 (2023)
Makraki E, Miliara S, Pagkalos M, Kokkinidis M, Mylonas E, Fadouloglou V
RgGuinier 6.1 nm
Dmax 24.0 nm
VolumePorod 175 nm3

SASDQS4 – Escherichia coli 6S:pRNA complex

6S RNA (SsrS gene)product RNA from E. coli 6S experimental SAS data
Escherichia coli 6S:pRNA complex Rg histogram
Sample: 6S RNA (SsrS gene) monomer, 59 kDa Escherichia coli RNA
Product RNA from E. coli 6S monomer, 7 kDa Escherichia coli RNA
Buffer: 20 mM Tris-HCl, 200 mM KCl, 5 mM MgCl2, pH: 8
Experiment: SAXS data collected at SWING, SOLEIL on 2016 Apr 4
Probing the conformational changes of in vivo overexpressed cell cycle regulator 6S ncRNA Frontiers in Molecular Biosciences 10 (2023)
Makraki E, Miliara S, Pagkalos M, Kokkinidis M, Mylonas E, Fadouloglou V
RgGuinier 4.9 nm
Dmax 20.0 nm
VolumePorod 260 nm3

SASDQF8 – G. gallus TRPV4 N-terminal Domain

Transient receptor potential cation channel subfamily V member 4 experimental SAS data
G. gallus TRPV4 N-terminal Domain Rg histogram
Sample: Transient receptor potential cation channel subfamily V member 4 monomer, 43 kDa Gallus gallus protein
Buffer: 20 mM Tris, 300 mM NaCl, 10 mM DTT, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Dec 16
Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity Nature Communications 14(1) (2023)
Goretzki B, Wiedemann C, McCray B, Schäfer S, Jansen J, Tebbe F, Mitrovic S, Nöth J, Cabezudo A, Donohue J, Jeffries C, Steinchen W, Stengel F, Sumner C, Hummer G, Hellmich U
RgGuinier 3.7 nm
Dmax 19.0 nm
VolumePorod 59 nm3

SASDQG8 – G. gallus TRPV4 N-terminal Domain, mutant 107-KRWRR-111 to 107-AAWAA-111

Transient receptor potential cation channel subfamily V member 4 experimental SAS data
G. gallus TRPV4 N-terminal Domain, mutant 107-KRWRR-111 to 107-AAWAA-111 Rg histogram
Sample: Transient receptor potential cation channel subfamily V member 4 monomer, 42 kDa Gallus gallus protein
Buffer: 20 mM Tris, 300 mM NaCl, 10 mM DTT, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Dec 16
Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity Nature Communications 14(1) (2023)
Goretzki B, Wiedemann C, McCray B, Schäfer S, Jansen J, Tebbe F, Mitrovic S, Nöth J, Cabezudo A, Donohue J, Jeffries C, Steinchen W, Stengel F, Sumner C, Hummer G, Hellmich U
RgGuinier 4.0 nm
Dmax 19.5 nm
VolumePorod 78 nm3