Small Angle Scattering Biological Data Bank SASBDB

Browse by MODEL: Hybrid

SASDSG8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 1.07 mg/mL

Adhesion G-protein coupled receptor G4 experimental SAS data

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces. J Biol Chem :105356 (2023)
Kieslich B, Weiße RH, Brendler J, Ricken A, Schöneberg T, Sträter N

R_g^Guinier	2.9	nm
D_max	9.0	nm
Volume^Porod	70	nm³

SASDSH8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 1.88 mg/mL

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	3.0	nm
D_max	9.7	nm
Volume^Porod	74	nm³

SASDSJ8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 4.37 mg/mL

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	3.0	nm
D_max	9.9	nm
Volume^Porod	76	nm³

SASDSK8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 6.38 mg/mL

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	3.0	nm
D_max	9.9	nm
Volume^Porod	77	nm³

SASDSL8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 7.51 mg/mL

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	2.9	nm
D_max	9.6	nm
Volume^Porod	77	nm³

SASDSM8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 9.15 mg/mL

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	2.9	nm
D_max	10.8	nm
Volume^Porod	78	nm³

SASDSV8 – Tyrosine-protein kinase Src (c-Src WT)

Proto-oncogene tyrosine-protein kinase Src experimental SAS data

Sample:	Proto-oncogene tyrosine-protein kinase Src monomer, 52 kDa Homo sapiens protein
Buffer:	20 mM Tris pH 8.0, 150 mM NaCl, 1% glycerol and 1 mM DTT, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 May 8

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function Nature Communications 14(1) (2023)
Cuesta-Hernández H, Contreras J, Soriano-Maldonado P, Sánchez-Wandelmer J, Yeung W, Martín-Hurtado A, Muñoz I, Kannan N, Llimargas M, Muñoz J, Plaza-Menacho I

R_g^Guinier	2.6	nm
D_max	8.9	nm
Volume^Porod	67	nm³

SASDSD2 – Recombinant Heavy-chain-only nanobody C5-Fc (glycosylated)

Immunoglobulin heavy constant gamma 1 experimental SAS data

Sample:	Immunoglobulin heavy constant gamma 1 monomer, 78 kDa Homo sapiens protein
Buffer:	20 mM L-histidine, 138 mM NaCl, 2.6 mM KCl buffer, pH: 6
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Sep 28

The solution structure of the heavy chain-only C5-Fc nanobody reveals exposed variable regions that are optimal for COVID-19 antigen interactions. J Biol Chem :105337 (2023)
Gao X, Thrush JW, Gor J, Naismith JH, Owens RJ, Perkins SJ

R_g^Guinier	3.9	nm
D_max	13.2	nm
Volume^Porod	157	nm³

SASDSE2 – Recombinant Heavy-chain-only nanobody C5-Fc (Deglycosylated)

Sample:	Immunoglobulin heavy constant gamma 1 monomer, 78 kDa Homo sapiens protein
Buffer:	20 mM L-histidine, 138 mM NaCl, 2.6 mM KCl buffer, pH: 6
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Sep 28

R_g^Guinier	4.0	nm
D_max	13.1	nm
Volume^Porod	175	nm³

SASDRG2 – Ligand free Xenosiderophore Utilization System B (XusB)

DUF4374 domain-containing protein experimental SAS data

Sample:	DUF4374 domain-containing protein monomer, 46 kDa Bacteroides thetaiotaomicron (strain … protein
Buffer:	20 mM Tris 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2021 May 9

Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection. Cell Host Microbe 31(10):1639-1654.e10 (2023)
Spiga L, Fansler RT, Perera YR, Shealy NG, Munneke MJ, David HE, Torres TP, Lemoff A, Ran X, Richardson KL, Pudlo N, Martens EC, Folta-Stogniew E, Yang ZJ, Skaar EP, Byndloss MX, Chazin WJ, Zhu W

R_g^Guinier	2.3	nm
D_max	7.4	nm
Volume^Porod	74	nm³

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