Small Angle Scattering Biological Data Bank SASBDB

Browse by MODEL: Hybrid

SASDSY6 – Outer membrane protein MIP (LpMIP) apo state

Outer membrane protein MIP experimental SAS data

Sample:	Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 10 mM DTT, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 16

Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding International Journal of Biological Macromolecules :126366 (2023)
Wiedemann C, Whittaker J, Carrillo V, Goretzki B, Dajka M, Tebbe F, Harder J, Krajczy P, Joseph B, Hausch F, Guskov A, Hellmich U

R_g^Guinier	3.1	nm
D_max	10.0	nm
Volume^Porod	66	nm³

SASDSZ6 – Outer membrane protein MIP (LpMIP) with bound inhibitor JK095

Sample:	Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 10 mM DTT, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 16

R_g^Guinier	3.1	nm
D_max	10.2	nm
Volume^Porod	65	nm³

SASDS27 – Outer membrane protein MIP (LpMIP) with bound inhibitor JK236

Sample:	Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 10 mM DTT, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Mar 16

R_g^Guinier	3.1	nm
D_max	9.4	nm
Volume^Porod	63	nm³

SASDS36 – Human RAD51C-XRCC3 at pH 8 in the presence of ATP and vanadate, a phosphate mimic

Isoform 1 of DNA repair protein RAD51 homolog 3DNA repair protein XRCC3 experimental SAS data

Sample:	Isoform 1 of DNA repair protein RAD51 homolog 3 monomer, 40 kDa Homo sapiens protein DNA repair protein XRCC3 monomer, 38 kDa Homo sapiens protein
Buffer:	10 mM HEPES pH 8, 100 mM NaCl, 2.5 mM ATP, 2.5 mM MgCl2, and 0.1 mM Na3VO4, pH: 8
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2017 May 5

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles Nature Communications 14(1) (2023)
Longo M, Roy S, Chen Y, Tomaszowski K, Arvai A, Pepper J, Boisvert R, Kunnimalaiyaan S, Keshvani C, Schild D, Bacolla A, Williams G, Tainer J, Schlacher K

R_g^Guinier	3.6	nm
D_max	14.0	nm
Volume^Porod	132	nm³

SASDR89 – Aromatic-L-amino-acid decarboxylase (AADC) - apo form

Aromatic-L-amino-acid decarboxylase (M17V) experimental SAS data

Sample:	Aromatic-L-amino-acid decarboxylase (M17V) dimer, 108 kDa Homo sapiens protein
Buffer:	50 mM HEPES, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Feb 28

Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: implication in AADC deficiency Protein Science (2023)
Bisello G, Ribeiro R, Perduca M, Belviso B, Polverino de' Laureto P, Giorgetti A, Caliandro R, Bertoldi M

R_g^Guinier	3.4	nm
D_max	15.8	nm
Volume^Porod	181	nm³

SASDR99 – Aromatic-L-amino-acid decarboxylase (AADC) - pyridoxal 5'-phosphate bound holo form

Sample:	Aromatic-L-amino-acid decarboxylase (M17V) dimer, 108 kDa Homo sapiens protein
Buffer:	50 mM HEPES, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Feb 28

R_g^Guinier	3.2	nm
D_max	14.9	nm
Volume^Porod	180	nm³

SASDRA9 – Aromatic-L-amino-acid decarboxylase (AADC) - dopa methylester DME-bound holo form

Sample:	Aromatic-L-amino-acid decarboxylase (M17V) dimer, 108 kDa Homo sapiens protein
Buffer:	50 mM HEPES, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Feb 28

R_g^Guinier	3.0	nm
D_max	14.5	nm
Volume^Porod	154	nm³

SASDM63 – RRM1-ZnF1-RRM2 triple domains of RNA-binding protein 5 (C191G mutant) in complex with GGCU_12 RNA

RNA Binding Motif protein 5 (I107T, C191G)Caspase-2 derived RNA GGCU_12 experimental SAS data

Sample:	RNA Binding Motif protein 5 (I107T, C191G) monomer, 26 kDa Homo sapiens protein Caspase-2 derived RNA GGCU_12 monomer, 4 kDa RNA
Buffer:	20 mM MES, 100 mM NaCl, 1 mM DTT, pH: 6.5
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, SFB 1035, Technische Universität München on 2017 Mar 1

Structural basis for specific RNA recognition by the alternative splicing factor RBM5. Nat Commun 14(1):4233 (2023)
Soni K, Jagtap PKA, Martínez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, Simon B, Valcárcel J, Sattler M

R_g^Guinier	2.2	nm
D_max	7.5	nm
Volume^Porod	42	nm³

SASDQE8 – G. gallus TRPV4 Ankyrin Repeat Domain

Transient receptor potential cation channel subfamily V member 4 experimental SAS data

Sample:	Transient receptor potential cation channel subfamily V member 4 monomer, 28 kDa Gallus gallus protein
Buffer:	20 mM Tris, 300 mM NaCl, 10 mM DTT, pH: 7
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Dec 16

Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity Nature Communications 14(1) (2023)
Goretzki B, Wiedemann C, McCray B, Schäfer S, Jansen J, Tebbe F, Mitrovic S, Nöth J, Cabezudo A, Donohue J, Jeffries C, Steinchen W, Stengel F, Sumner C, Hummer G, Hellmich U

R_g^Guinier	2.3	nm
D_max	11.5	nm
Volume^Porod	41	nm³

SASDPV7 – FAD-dependent monooxygenase from Stenotrophomonas maltophilia (no reducing agent)

Monooxygenase (M154I, A283T) experimental SAS data

Sample:	Monooxygenase (M154I, A283T) monomer, 39 kDa Stenotrophomonas maltophilia protein
Buffer:	25 mM Bis-Tris, 150 mM NaCl, pH: 6.5
Experiment:	SAXS data collected at Anton Paar SAXSpoint 2.0, Institute of Biotechnology, Czech Academy of Sciences/Centre of Molecular Structure on 2022 Jan 10

Tetracycline-modifying enzyme Sm TetX from Stenotrophomonas maltophilia Acta Crystallographica Section F Structural Biology Communications 79(7):180-192 (2023)
Malý M, Kolenko P, Stránský J, Švecová L, Dušková J, Koval' T, Skálová T, Trundová M, Adámková K, Černý J, Božíková P, Dohnálek J

R_g^Guinier	2.4	nm
D_max	6.8	nm
Volume^Porod	59	nm³

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