Small Angle Scattering Biological Data Bank SASBDB

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SASDXR2 – RAR/RXR heterodimer : BMS493 : IR0 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaInverted Repeat binding site with zero-base-pair spacing experimental SAS data

Sample:	Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Inverted Repeat binding site with zero-base-pair spacing monomer, 11 kDa DNA
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2022 Apr 20

New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. Nucleic Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A

R_g^Guinier	3.9	nm
D_max	12.9	nm
Volume^Porod	121	nm³

SASDXS2 – RAR/RXR heterodimer : BMS493 : NCoR NID : DR0L element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Direct Repeat binding site with zero-base-pair spacing (long sequence)Retinoid X receptor alphaNuclear receptor corepressor 1 experimental SAS data

Sample:	Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Direct Repeat binding site with zero-base-pair spacing (long sequence) monomer, 19 kDa DNA Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2022 Dec 12

R_g^Guinier	5.4	nm
D_max	20.1	nm
Volume^Porod	363	nm³

SASDXT2 – RAR/RXR heterodimer : BMS493 : NCoR NID : DR1 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with one-base-pair spacingNuclear receptor corepressor 1 experimental SAS data

Sample:	Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Direct Repeat binding site with one-base-pair spacing monomer, 11 kDa DNA Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2022 Apr 20

R_g^Guinier	5.6	nm
D_max	21.8	nm
Volume^Porod	330	nm³

SASDXU2 – RAR/RXR heterodimer : BMS493 : NCoR NID : DR5 element

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaDirect Repeat binding site with five-base-pair spacingNuclear receptor corepressor 1 experimental SAS data

Sample:	Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Direct Repeat binding site with five-base-pair spacing monomer, 13 kDa DNA Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2022 Dec 12

R_g^Guinier	5.7	nm
D_max	21.8	nm
Volume^Porod	363	nm³

SASDXV2 – RAR/RXR heterodimer : BMS493 : NCoR NID : IR0 element

Sample:	Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Inverted Repeat binding site with zero-base-pair spacing monomer, 11 kDa DNA Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2022 Apr 20

R_g^Guinier	5.5	nm
D_max	22.9	nm
Volume^Porod	257	nm³

SASDWZ6 – ABC transporter permease protein extracellular domain from S.agalactiae (SaNsrP ECD)

ABC transporter, permease protein, extracellular domain experimental SAS data

ABC transporter, permease protein, extracellular domain Kratky plot

Sample:	ABC transporter, permease protein, extracellular domain monomer, 23 kDa Streptococcus agalactiae serotype … protein
Buffer:	25 mM MES, 500 mM NaCl, pH: 6
Experiment:	SAXS data collected at BM29, ESRF on 2020 Dec 3

The extracellular domain of SaNSrFP binds bacitracin and allows the identification of new members of the BceAB transporter family Frontiers in Microbiology 16 (2025)
Mammen C, Gottstein J, Cea P, Tantsur K, Reiners J, Bonus M, Gohlke H, Smits S

R_g^Guinier	2.4	nm
D_max	9.0	nm
Volume^Porod	50	nm³

SASDW27 – ABC transporter ATP-binding protein - ABC transporter, permease protein - complex from S.agalactiae (SaNsrFP)

ABC transporter ATP-binding proteinABC transporter, permease protein experimental SAS data

ABC transporter ATP-binding protein ABC transporter, permease protein Kratky plot

Sample:	ABC transporter ATP-binding protein dimer, 62 kDa Streptococcus agalactiae protein ABC transporter, permease protein monomer, 74 kDa Streptococcus agalactiae serotype … protein
Buffer:	50 mM Tris, 300 mM NaCl, 10 % Glycerol, 0.005 % LMNG,, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2023 Apr 25

R_g^Guinier	5.8	nm
D_max	20.5	nm
Volume^Porod	735	nm³

SASDX29 – Non Structural Protein 15 and ADPRP Macrodomain D

Non structural Protein 15 in Complex with ADPRP Macrodomain experimental SAS data

Non structural Protein 15 in Complex with ADPRP Macrodomain Kratky plot

Sample:	Non structural Protein 15 in Complex with ADPRP Macrodomain monomer, 254 kDa Severe acute respiratory … protein
Buffer:	20mM HEPES, 150mM Nacl, pH: 7.5
Experiment:	SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2025 Mar 20

Non Structural Protein 15 in Complex with ADPRP Macrodomain of SARS CoV 2
Hira Singh Gariya

R_g^Guinier

6.1

SASDXJ5 – Calcium/calmodulin-dependent protein kinase type II (CaMKII) subunit alpha holoenzyme with Exon 14 as the linker region

Calcium/calmodulin-dependent protein kinase type II subunit alpha (Δ1-6; Q223K; Δ329-344) experimental SAS data

Calcium/calmodulin-dependent protein kinase type II subunit alpha (Δ1-6; Q223K; Δ329-344) Kratky plot

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha (Δ1-6; Q223K; Δ329-344) dodecamer, 620 kDa Homo sapiens protein
Buffer:	50 mM Tris , 0.2 mM CaCl2, 150 mM KCl, 10 mM MgCl2, 2 mM ATP, pH: 8
Experiment:	SAXS data collected at Rigaku/BioSAXS-2000 SAXS, Institute for Applied Life Sciences/Biophysical Characterization on 2024 Dec 18

A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation - revision
Bao Nguyen Viet

R_g^Guinier

8.1

SASDXK5 – Calcium/calmodulin-dependent protein kinase type II (CaMKII) subunit holoenzyme with Exon 14 as the linker region + 10 nM Ca2+/CaM

Sample:	Calcium/calmodulin-dependent protein kinase type II subunit alpha (Δ1-6; Q223K; Δ329-344) dodecamer, 620 kDa Homo sapiens protein
Buffer:	50 mM Tris , 0.2 mM CaCl2, 150 mM KCl, 10 mM MgCl2, 2 mM ATP, pH: 8
Experiment:	SAXS data collected at Rigaku/BioSAXS-2000 SAXS, Institute for Applied Life Sciences/Biophysical Characterization on 2024 Dec 18

A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation - revision
Bao Nguyen Viet

R_g^Guinier

7.5

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