Small Angle Scattering Biological Data Bank SASBDB

Browse by MODEL: No model

SASDSG6 – Human Ubiquilin-2, ∆STI1-2 domain deletion (UBQLN2∆STI1-2)

Ubiquilin-2 (∆379-462) experimental SAS data

Sample:	Ubiquilin-2 (∆379-462) monomer, 56 kDa Homo sapiens protein
Buffer:	20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 8

Short disordered N-termini & proline-rich domain are major regulators of UBQLN1/2/4 phase separation.
Sarasi Galagedera

R_g^Guinier	4.4	nm
D_max	22.4	nm
Volume^Porod	121	nm³

SASDSH6 – Human Ubiquilin-2, PXX domain deletion (UBQLN2∆PXX)

Ubiquilin-2 (∆487-538) experimental SAS data

Sample:	Ubiquilin-2 (∆487-538) dimer, 122 kDa Homo sapiens protein
Buffer:	20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 8

Short disordered N-termini & proline-rich domain are major regulators of UBQLN1/2/4 phase separation.
Sarasi Galagedera

R_g^Guinier	4.8	nm
D_max	19.5	nm
Volume^Porod	288	nm³

SASDSZ4 – HIV-1 Reverse Transcriptase heterodimer (p66/p51) unliganded form

Gag-Pol polyprotein (588-1147: Reverse transcriptase/ribonuclease H; p66)Gag-Pol polyprotein (588-1027: Reverse transcriptase p51; p51 RT) experimental SAS data

Gag-Pol polyprotein (588-1147: Reverse transcriptase/ribonuclease H; p66) Gag-Pol polyprotein (588-1027: Reverse transcriptase p51; p51 RT) Kratky plot

Sample:	Gag-Pol polyprotein (588-1147: Reverse transcriptase/ribonuclease H; p66) monomer, 67 kDa Human immunodeficiency virus … protein Gag-Pol polyprotein (588-1027: Reverse transcriptase p51; p51 RT) monomer, 53 kDa Human immunodeficiency virus … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, 1 mM TCEP, pH: 7
Experiment:	SAXS data collected at BL1.3W, Synchrotron Light Research Institute (SLRI) on 2017 Jun 19

Biophysical Characterization of p51 and p66 Monomers of HIV-1 Reverse Transcriptase with Their Inhibitors. Protein J (2023)
Seetaha S, Kamonsutthipaijit N, Yagi-Utsumi M, Seako Y, Yamaguchi T, Hannongbua S, Kato K, Choowongkomon K

R_g^Guinier	3.3	nm
D_max	9.9	nm
Volume^Porod	153	nm³

SASDS25 – HIV-1 Reverse Transcriptase heterodimer (p66/p51) bound with Nevirapine

Sample:	Gag-Pol polyprotein (588-1147: Reverse transcriptase/ribonuclease H; p66) monomer, 67 kDa Human immunodeficiency virus … protein Gag-Pol polyprotein (588-1027: Reverse transcriptase p51; p51 RT) monomer, 53 kDa Human immunodeficiency virus … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, 1 mM TCEP, pH: 7
Experiment:	SAXS data collected at BL1.3W, Synchrotron Light Research Institute (SLRI) on 2017 Jun 19

R_g^Guinier	3.5	nm
D_max	10.9	nm
Volume^Porod	161	nm³

SASDS35 – HIV-1 Reverse Transcriptase monomer (p66 subunit with W401A mutation) unliganded form

Gag-Pol polyprotein (588-1147: W988A mutant; Reverse transcriptase/ribonuclease H; p66) experimental SAS data

Gag-Pol polyprotein (588-1147: W988A mutant; Reverse transcriptase/ribonuclease H; p66) Kratky plot

Sample:	Gag-Pol polyprotein (588-1147: W988A mutant; Reverse transcriptase/ribonuclease H; p66) monomer, 67 kDa Human immunodeficiency virus … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, 1 mM TCEP, pH: 7
Experiment:	SAXS data collected at BL1.3W, Synchrotron Light Research Institute (SLRI) on 2017 Jun 19

R_g^Guinier	3.1	nm
D_max	10.7	nm
Volume^Porod	98	nm³

SASDS45 – HIV-1 Reverse Transcriptase heterodimer (p66/p51) bound with Efavirenz

Sample:	Gag-Pol polyprotein (588-1147: Reverse transcriptase/ribonuclease H; p66) monomer, 67 kDa Human immunodeficiency virus … protein Gag-Pol polyprotein (588-1027: Reverse transcriptase p51; p51 RT) monomer, 53 kDa Human immunodeficiency virus … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, 1 mM TCEP, pH: 7
Experiment:	SAXS data collected at BL1.3W, Synchrotron Light Research Institute (SLRI) on 2017 Jun 19

R_g^Guinier	3.7	nm
D_max	11.3	nm
Volume^Porod	178	nm³

SASDS55 – HIV-1 Reverse Transcriptase monomer (p66 subunit with W401A mutation) bound with Nevirapine

Sample:	Gag-Pol polyprotein (588-1147: W988A mutant; Reverse transcriptase/ribonuclease H; p66) monomer, 67 kDa Human immunodeficiency virus … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, 1 mM TCEP, pH: 7
Experiment:	SAXS data collected at BL1.3W, Synchrotron Light Research Institute (SLRI) on 2017 Jun 19

R_g^Guinier	3.5	nm
D_max	11.3	nm
Volume^Porod	134	nm³

SASDS65 – HIV-1 Reverse Transcriptase monomer (p66 subunit with W401A mutation) bound with Efavirenz

Sample:	Gag-Pol polyprotein (588-1147: W988A mutant; Reverse transcriptase/ribonuclease H; p66) monomer, 67 kDa Human immunodeficiency virus … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, 1 mM TCEP, pH: 7
Experiment:	SAXS data collected at BL1.3W, Synchrotron Light Research Institute (SLRI) on 2017 Jun 19

R_g^Guinier	4.6	nm
D_max	15.0	nm
Volume^Porod	270	nm³

SASDS75 – HIV-1 Reverse Transcriptase monomer (p51 subunit with W401A mutation) unliganded form

Gag-Pol polyprotein (588-1027: W988A mutant; Reverse transcriptase p51; p51 RT) experimental SAS data

Gag-Pol polyprotein (588-1027: W988A mutant; Reverse transcriptase p51; p51 RT) Kratky plot

Sample:	Gag-Pol polyprotein (588-1027: W988A mutant; Reverse transcriptase p51; p51 RT) monomer, 53 kDa Human immunodeficiency virus … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, 1 mM TCEP, pH: 7
Experiment:	SAXS data collected at BL1.3W, Synchrotron Light Research Institute (SLRI) on 2017 Jun 19

R_g^Guinier	2.8	nm
D_max	9.8	nm
Volume^Porod	84	nm³

SASDS85 – HIV-1 Reverse Transcriptase monomer (p51 subunit with W401A mutation) bound with Nevirapine

Sample:	Gag-Pol polyprotein (588-1027: W988A mutant; Reverse transcriptase p51; p51 RT) monomer, 53 kDa Human immunodeficiency virus … protein
Buffer:	20 mM Tris-HCl, 100 mM NaCl, 1 mM TCEP, pH: 7
Experiment:	SAXS data collected at BL1.3W, Synchrotron Light Research Institute (SLRI) on 2017 Jun 19

R_g^Guinier	3.1	nm
D_max	11.1	nm
Volume^Porod	103	nm³

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