Browse by ORGANISM: Homo sapiens (Human)

SASDNK7 – Guanine-rich DNA derived from the promoter region of c-MYC gene (MYC22-G14T/G23T) with KCl

MYC22-G14T/G23T experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: MYC22-G14T/G23T monomer, 7 kDa Homo sapiens DNA
Buffer: 50 mM Tris, 30 mM KCl, pH: 8
Experiment: SAXS data collected at BL-10C, Photon Factory (PF), High Energy Accelerator Research Organization (KEK) on 2022 Feb 27
Small-angle X-ray scattering data of a guanine-rich DNA derived from the promoter region of c-MYC gene in solution Data in Brief :108285 (2022)
Miyauchi K, Imamura H, Yamaoki Y, Kato M
RgGuinier 1.3 nm
Dmax 5.3 nm
VolumePorod 9 nm3

SASDNL7 – Guanine-rich DNA derived from the promoter region of c-MYC gene (MYC22-G14T/G23T) with 18-crown-6

MYC22-G14T/G23T experimental SAS data
MYC22-G14T/G23T Kratky plot
Sample: MYC22-G14T/G23T monomer, 7 kDa Homo sapiens DNA
Buffer: 50 mM Tris, 100 mM 18-crown-6, pH: 8
Experiment: SAXS data collected at BL-10C, Photon Factory (PF), High Energy Accelerator Research Organization (KEK) on 2022 Feb 27
Small-angle X-ray scattering data of a guanine-rich DNA derived from the promoter region of c-MYC gene in solution Data in Brief :108285 (2022)
Miyauchi K, Imamura H, Yamaoki Y, Kato M
RgGuinier 1.6 nm
Dmax 6.0 nm
VolumePorod 10 nm3

SASDKK3 – SEC-SAXS of Presequence Protease (PreP)

Presequence protease, mitochondrial experimental SAS data
Presequence protease, mitochondrial Kratky plot
Sample: Presequence protease, mitochondrial monomer, 115 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 7.7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 4
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nature Communications 13(1) (2022)
Liang W, Wijaya J, Wei H, Noble A, Mancl J, Mo S, Lee D, Lin King J, Pan M, Liu C, Koehler C, Zhao M, Potter C, Carragher B, Li S, Tang W
RgGuinier 3.2 nm
Dmax 9.1 nm
VolumePorod 170 nm3

SASDKL3 – SEC-SAXS of Presequence Protease (PreP) with inhibitor MitoBloCK-60 (MB-60)

Presequence protease, mitochondrial experimental SAS data
Presequence protease, mitochondrial Kratky plot
Sample: Presequence protease, mitochondrial monomer, 115 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 7.7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 7
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nature Communications 13(1) (2022)
Liang W, Wijaya J, Wei H, Noble A, Mancl J, Mo S, Lee D, Lin King J, Pan M, Liu C, Koehler C, Zhao M, Potter C, Carragher B, Li S, Tang W
RgGuinier 3.1 nm
Dmax 9.1 nm
VolumePorod 165 nm3

SASDKM3 – SEC-SAXS of Presequence Protease (PreP) with pre-sequence of citrate synthase (1-27)

Presequence protease, mitochondrialCitrate synthase, mitochondrial experimental SAS data
Presequence protease, mitochondrial Citrate synthase, mitochondrial Kratky plot
Sample: Presequence protease, mitochondrial monomer, 115 kDa Homo sapiens protein
Citrate synthase, mitochondrial monomer, 3 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl , 20 mM EDTA, pH: 7.7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 4
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nature Communications 13(1) (2022)
Liang W, Wijaya J, Wei H, Noble A, Mancl J, Mo S, Lee D, Lin King J, Pan M, Liu C, Koehler C, Zhao M, Potter C, Carragher B, Li S, Tang W
RgGuinier 3.1 nm
Dmax 8.7 nm
VolumePorod 165 nm3

SASDKN3 – SEC-SAXS of Presequence Protease (PreP) with Amyloid beta precursor protein (1-40)

Presequence protease, mitochondrialAmyloid-beta precursor protein experimental SAS data
Presequence protease, mitochondrial Amyloid-beta precursor protein Kratky plot
Sample: Presequence protease, mitochondrial monomer, 115 kDa Homo sapiens protein
Amyloid-beta precursor protein monomer, 4 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl , 20 mM EDTA, pH: 7.7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 7
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nature Communications 13(1) (2022)
Liang W, Wijaya J, Wei H, Noble A, Mancl J, Mo S, Lee D, Lin King J, Pan M, Liu C, Koehler C, Zhao M, Potter C, Carragher B, Li S, Tang W
RgGuinier 3.0 nm
Dmax 8.5 nm
VolumePorod 175 nm3

SASDMA5 – cone-rod homeobox protein (a peptide of the DNA binding domain of CRX)

Cone-rod homeobox protein experimental SAS data
OTHER model
Sample: Cone-rod homeobox protein monomer, 7 kDa Homo sapiens protein
Buffer: 50 mM sodium phosphate,100 mM NaCl, and 5 mM imidazole, pH: 7
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2021 Jun 15
Structural and functional analysis of the human Cone-rod homeobox transcription factor. Proteins (2022)
Clanor PB, Buchholz C, Hayes JE, Friedman MA, White AM, Enke RA, Berndsen CE
RgGuinier 1.2 nm
Dmax 4.0 nm
VolumePorod 10 nm3

SASDKJ8 – CUB domain-containing protein 1 (CDCP1)

CUB domain-containing protein 1 experimental SAS data
CUB domain-containing protein 1 Kratky plot
Sample: CUB domain-containing protein 1 monomer, 77 kDa Homo sapiens protein
Buffer: 10 mM phosphate, 137 mM NaCl, 2.7 mM KCl,, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Jul 29
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers. J Clin Invest 132(4) (2022)
Lim SA, Zhou J, Martinko AJ, Wang YH, Filippova EV, Steri V, Wang D, Remesh SG, Liu J, Hann B, Kossiakoff AA, Evans MJ, Leung KK, Wells JA
RgGuinier 4.4 nm
Dmax 14.5 nm
VolumePorod 185 nm3

SASDKK8 – Cleaved CUB domain containing protein 1 (CDCP1)

Cleaved - CUB domain-containing protein 1 (N-terminus)Cleaved - CUB domain-containing protein 1 (C-terminus) experimental SAS data
Cleaved - CUB domain-containing protein 1 (N-terminus) Cleaved - CUB domain-containing protein 1 (C-terminus) Kratky plot
Sample: Cleaved - CUB domain-containing protein 1 (N-terminus) monomer, 38 kDa Homo sapiens protein
Cleaved - CUB domain-containing protein 1 (C-terminus) monomer, 39 kDa Homo sapiens protein
Buffer: 10 mM phosphate, 137 mM NaCl, 2.7 mM KCl,, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Jul 29
Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers. J Clin Invest 132(4) (2022)
Lim SA, Zhou J, Martinko AJ, Wang YH, Filippova EV, Steri V, Wang D, Remesh SG, Liu J, Hann B, Kossiakoff AA, Evans MJ, Leung KK, Wells JA
RgGuinier 4.4 nm
Dmax 14.3 nm
VolumePorod 182 nm3

SASDNZ3 – Heterodimerization between the nuclear receptor subfamily proteins PXR and CAR

Nuclear receptor subfamily 1 group I member 2Nuclear receptor subfamily 1 group I member 3 experimental SAS data
DAMMIF model
Sample: Nuclear receptor subfamily 1 group I member 2 monomer, 39 kDa Homo sapiens protein
Nuclear receptor subfamily 1 group I member 3 monomer, 32 kDa Homo sapiens protein
Buffer: 25 mM Hepes, 150 mM NaCl, 5% glycerol, 5 mM DTT, pH: 7.9
Experiment: SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2021 Oct 8
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
Shirish chodankar
RgGuinier 2.7 nm
Dmax 10.1 nm
VolumePorod 56 nm3