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9 hits found for Zhen Xu

SASDTW2 – Protein phosphatase 2A (PP2A)-B56δ holoenzyme wildtype

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformIsoform Delta-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (R160H)Isoform 1 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform experimental SAS data
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Isoform Delta-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (R160H) Isoform 1 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Kratky plot
Sample: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform monomer, 65 kDa Homo sapiens protein
Isoform Delta-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (R160H) monomer, 70 kDa Homo sapiens protein
Isoform 1 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform monomer, 36 kDa Homo sapiens protein
Buffer: 25 mM Tris, 150 mM NaCl, 50 µM MnCl2, pH: 8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Nov 20
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc Natl Acad Sci U S A 121(1):e2310727120 (2024)
...Xu Z, Wei H, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Chung WK, Honkanen RE, Suzuki A, Huang X, Strack S, Xing Y
RgGuinier 4.0 nm
Dmax 12.0 nm
VolumePorod 266 nm3

SASDTX2 – Protein phosphatase 2A (PP2A)-B56δ holoenzyme E198K mutant

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformIsoform 1 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformIsoform Delta-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (R160H, E198K) experimental SAS data
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Isoform 1 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Isoform Delta-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (R160H, E198K) Kratky plot
Sample: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform monomer, 65 kDa Homo sapiens protein
Isoform 1 of Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform monomer, 36 kDa Homo sapiens protein
Isoform Delta-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (R160H, E198K) monomer, 70 kDa Homo sapiens protein
Buffer: 25 mM Tris, 150 mM NaCl, 50 µM MnCl2, pH: 8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Nov 20
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc Natl Acad Sci U S A 121(1):e2310727120 (2024)
...Xu Z, Wei H, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Chung WK, Honkanen RE, Suzuki A, Huang X, Strack S, Xing Y
RgGuinier 4.2 nm
Dmax 14.0 nm
VolumePorod 305 nm3

SASDWG3 – MBP-tagged C-terminal domain of CpoS (Candidate inclusion membrane protein)

Candidate inclusion membrane protein (MBP-tagged) experimental SAS data
Candidate inclusion membrane protein (MBP-tagged) Kratky plot
Sample: Candidate inclusion membrane protein (MBP-tagged) tetramer, 235 kDa Chlamydia trachomatis serovar … protein
Buffer: 20 mM Tris-HCl, 50 mM NaCl, 1 mM EDTA, 2% glycerol, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2023 Feb 15
Tetramer formation of CpoS facilitates Inc-Inc interactions during Chlamydia trachomatis infection
Zhen Xu
RgGuinier 7.1 nm
Dmax 30.3 nm
VolumePorod 625 nm3

SASDLJ7 – Human potassium voltage-gated (Kv2.1) channel T1 domain at pH8.0

Potassium voltage-gated channel subfamily B member 1 experimental SAS data
Potassium voltage-gated channel subfamily B member 1 Kratky plot
Sample: Potassium voltage-gated channel subfamily B member 1 pentamer, 73 kDa Homo sapiens protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 5% v/v glycerol, 0.01% Triton X-100, 10 mM β-mercaptoethanol, pH: 8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Jul 13
Pentameric assembly of the Kv2.1 tetramerization domain Acta Crystallographica Section D Structural Biology 78(6):792-802 (2022)
Xu Z, Khan S, Schnicker N, Baker S
RgGuinier 2.8 nm
Dmax 8.0 nm
VolumePorod 140 nm3

SASDNF8 – LARGE xylosyl- and glucuronyltransferase 1 (LARGE1dTM) dimer

Xylosyl- and glucuronyltransferase LARGE1 experimental SAS data
DAMMIF model
Sample: Xylosyl- and glucuronyltransferase LARGE1 dimer, 179 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Mar 18
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan. Nat Commun 16(1):9028 (2025)
...Xu Z, Yan R, Yu Z, Davulcu O, Yang T, Hopkins J, Anderson ME, Venzke D, Campbell KP
RgGuinier 4.4 nm
Dmax 18.4 nm
VolumePorod 264 nm3

SASDNG8 – LARGE xylosyl- and glucuronyltransferase 1 (LARGE1dTM) dimer treated with PNGase F enzyme

Xylosyl- and glucuronyltransferase LARGE1 experimental SAS data
DAMMIF model
Sample: Xylosyl- and glucuronyltransferase LARGE1 dimer, 179 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Mar 18
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan. Nat Commun 16(1):9028 (2025)
...Xu Z, Yan R, Yu Z, Davulcu O, Yang T, Hopkins J, Anderson ME, Venzke D, Campbell KP
RgGuinier 4.3 nm
Dmax 18.0 nm

SASDNH8 – Xylosyl- and glucuronyltransferase LARGE2 (LARGE2dTM) dimer

Xylosyl- and glucuronyltransferase LARGE2 experimental SAS data
DAMMIN model
Sample: Xylosyl- and glucuronyltransferase LARGE2 dimer, 168 kDa Mus musculus protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Mar 18
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan. Nat Commun 16(1):9028 (2025)
...Xu Z, Yan R, Yu Z, Davulcu O, Yang T, Hopkins J, Anderson ME, Venzke D, Campbell KP
RgGuinier 4.2 nm
Dmax 16.5 nm

SASDNJ8 – Xylosyl- and glucuronyltransferase LARGE2 (LARGE2dTM) dimer treated with PNGase F enzyme

Xylosyl- and glucuronyltransferase LARGE2 experimental SAS data
DAMMIN model
Sample: Xylosyl- and glucuronyltransferase LARGE2 dimer, 168 kDa Mus musculus protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Mar 18
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan. Nat Commun 16(1):9028 (2025)
...Xu Z, Yan R, Yu Z, Davulcu O, Yang T, Hopkins J, Anderson ME, Venzke D, Campbell KP
RgGuinier 4.1 nm
Dmax 15.9 nm
VolumePorod 231 nm3

SASDTW8 – Staphylococcus aureus Fatty Acid Kinase A

Uncharacterized protein SAUSA300_1119 experimental SAS data
DAMMIF model
Sample: Uncharacterized protein SAUSA300_1119 dimer, 125 kDa Staphylococcus aureus (strain … protein
Buffer: 50 mM Tris, 150 mM KCl, 1 mM TCEP, 5% glycerol, pH: 7.4
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Oct 5
Molecular insights into the structure and function of the Staphylococcus aureus fatty acid kinase. J Biol Chem 300(12):107920 (2024)
...Xu Z, Ryan BJ, DeMars ZR, Ridder MJ, Johnson DK, Krute CN, Flynn TS, Kashipathy MM, Battaile KP, Schnicker N, Lovell S, Freudenthal BD, Bose JL
RgGuinier 4.3 nm
Dmax 16.0 nm
VolumePorod 219 nm3