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11 hits found for Ubiquilin-2

SASDSA6 – ...Ubiquilin-2 (UBQLN2)

Ubiquilin-2 experimental SAS data
Ubiquilin-2 Kratky plot
Sample: Ubiquilin-2 dimer, 131 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 8
Short disordered N-termini & proline-rich domain are major regulators of UBQLN1/2/4 phase separation. Biophys J (2023)
Dao TP, Rajendran A, Galagedera SKK, Haws W, Castañeda CA
RgGuinier 5.2 nm
Dmax 22.5 nm
VolumePorod 330 nm3

SASDSC6 – ...Ubiquilin-2, ∆STI1-1 domain deletion (UBQLN2∆STI1-1)

Ubiquilin-2 (∆170-260) experimental SAS data
Ubiquilin-2 (∆170-260) Kratky plot
Sample: Ubiquilin-2 (∆170-260) dimer, 110 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 16
UBQLN2 domain deletion constructs
Sarasi Galagedera
RgGuinier 5.4 nm
Dmax 26.0 nm
VolumePorod 357 nm3

SASDSD6 – ...Ubiquilin-2 with ∆UBL and ∆STI1-1 domain deletions (UBQLN2∆STI1-1∆UBL)

Ubiquilin-2 (∆33-103, ∆170-260) experimental SAS data
Ubiquilin-2 (∆33-103, ∆170-260) Kratky plot
Sample: Ubiquilin-2 (∆33-103, ∆170-260) dimer, 94 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 16
UBQLN2 domain deletion constructs
Sarasi Galagedera
RgGuinier 5.6 nm
Dmax 24.5 nm
VolumePorod 326 nm3

SASDSE6 – ...Ubiquilin-2, ∆1-108 N-terminal deletion (UBQLN2 109-624)

Ubiquilin-2 (∆1-108) experimental SAS data
Ubiquilin-2 (∆1-108) Kratky plot
Sample: Ubiquilin-2 (∆1-108) dimer, 108 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 16
UBQLN2 domain deletion constructs
Sarasi Galagedera
RgGuinier 5.2 nm
Dmax 23.3 nm
VolumePorod 281 nm3

SASDSF6 – ...Ubiquilin-2, C-terminal construct (UBQLN2 450-624W)

Ubiquilin-2 (∆1-449)-W experimental SAS data
Ubiquilin-2 (∆1-449)-W Kratky plot
Sample: Ubiquilin-2 (∆1-449)-W dimer, 35 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 16
UBQLN2 domain deletion constructs
Sarasi Galagedera
RgGuinier 3.8 nm
Dmax 18.5 nm
VolumePorod 50 nm3

SASDSG6 – ...Ubiquilin-2, ∆STI1-2 domain deletion (UBQLN2∆STI1-2)

Ubiquilin-2 (∆379-462) experimental SAS data
Ubiquilin-2 (∆379-462) Kratky plot
Sample: Ubiquilin-2 (∆379-462) monomer, 56 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 8
Short disordered N-termini & proline-rich domain are major regulators of UBQLN1/2/4 phase separation.
Sarasi Galagedera
RgGuinier 4.4 nm
Dmax 22.4 nm
VolumePorod 121 nm3

SASDSH6 – ...Ubiquilin-2, PXX domain deletion (UBQLN2∆PXX)

Ubiquilin-2 (∆487-538) experimental SAS data
Ubiquilin-2 (∆487-538) Kratky plot
Sample: Ubiquilin-2 (∆487-538) dimer, 122 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 8
Short disordered N-termini & proline-rich domain are major regulators of UBQLN1/2/4 phase separation.
Sarasi Galagedera
RgGuinier 4.8 nm
Dmax 19.5 nm
VolumePorod 288 nm3

SASDSJ6 – ...Ubiquilin-2, P497E phosphomimetic point mutant (UBQLN2 P497E)

Ubiquilin-2 (P497E) experimental SAS data
Ubiquilin-2 (P497E) Kratky plot
Sample: Ubiquilin-2 (P497E) dimer, 131 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 8
UBQLN2 domain deletion constructs
Sarasi Galagedera
RgGuinier 5.3 nm
Dmax 21.3 nm
VolumePorod 340 nm3

SASDSK6 – ...Ubiquilin-2, P497L ALS-linked point mutant (UBQLN2 P497L)

Ubiquilin-2 (P497L) experimental SAS data
Ubiquilin-2 (P497L) Kratky plot
Sample: Ubiquilin-2 (P497L) dimer, 131 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Jun 8
UBQLN2 domain deletion constructs
Sarasi Galagedera
RgGuinier 7.3 nm
Dmax 28.8 nm
VolumePorod 1365 nm3

SASDSL6 – ...Ubiquilin-2, R12G R15D Q21E triple point mutant (UBQLN2 GDE)

Ubiquilin-2 (R12G, R15D, Q21E) experimental SAS data
Ubiquilin-2 (R12G, R15D, Q21E) Kratky plot
Sample: Ubiquilin-2 (R12G, R15D, Q21E) dimer, 131 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2023 Mar 22
UBQLN2 domain deletion constructs
Sarasi Galagedera
RgGuinier 5.1 nm
Dmax 21.3 nm
VolumePorod 330 nm3

SASDSM6 – ...Ubiquilin-2, ∆551-569 deletion construct (UBQLN2∆551-569)

Ubiquilin-2 (∆551-569) experimental SAS data
Ubiquilin-2 (∆551-569) Kratky plot
Sample: Ubiquilin-2 (∆551-569) dimer, 127 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2023 Mar 22
UBQLN2 domain deletion constructs
Sarasi Galagedera
RgGuinier 5.2 nm
Dmax 23.4 nm
VolumePorod 332 nm3