Small Angle Scattering Biological Data Bank SASBDB


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30 hits found for Monsen

SASDKF3 – Human telomere monomer G4 hybrid-2 form (2JSL)

Human telomere G-quadruplex hybrid-2 form experimental SAS data

Sample:	Human telomere G-quadruplex hybrid-2 form monomer, 8 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Aug 14

The solution structures of higher-order human telomere G-quadruplex multimers. Nucleic Acids Res (2021)
Monsen RC, Chakravarthy S, Dean WL, Chaires JB, Trent JO

R_g^Guinier	1.2	nm
D_max	3.8	nm
Volume^Porod	9	nm³

SASDKG3 – Human wild-type telomere 48-mer d(TTAGGG)8

Human Telomere Repeat (TTAGGG)8 experimental SAS data

Sample:	Human Telomere Repeat (TTAGGG)8 monomer, 15 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Aug 14

The solution structures of higher-order human telomere G-quadruplex multimers. Nucleic Acids Res (2021)
Monsen RC, Chakravarthy S, Dean WL, Chaires JB, Trent JO

R_g^Guinier	1.9	nm
D_max	6.4	nm
Volume^Porod	16	nm³

SASDKH3 – Human wild-type telomere 72mer d(TTAGGG)12

Human Telomere Repeat (TTAGGG)12 experimental SAS data

Sample:	Human Telomere Repeat (TTAGGG)12 monomer, 23 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Aug 14

The solution structures of higher-order human telomere G-quadruplex multimers. Nucleic Acids Res (2021)
Monsen RC, Chakravarthy S, Dean WL, Chaires JB, Trent JO

R_g^Guinier	2.5	nm
D_max	8.7	nm
Volume^Porod	26	nm³

SASDKJ3 – Human telomere DNA d(TTAGGG)96

Human Telomere 96mer experimental SAS data

Sample:	Human Telomere 96mer monomer, 31 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 19

The solution structures of higher-order human telomere G-quadruplex multimers. Nucleic Acids Res (2021)
Monsen RC, Chakravarthy S, Dean WL, Chaires JB, Trent JO

R_g^Guinier	3.2	nm
D_max	10.9	nm
Volume^Porod	38	nm³

SASDPU6 – Duplex-G4-duplex DNA

Sample:	Duplex-G4-duplex monomer, 29 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Jun 16

Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 Å resolution with cryo-EM. Nucleic Acids Res (2023)
Monsen RC, Chua EYD, Hopkins JB, Chaires JB, Trent JO

R_g^Guinier	3.2	nm
D_max	13.3	nm
Volume^Porod	59	nm³

SASDHM3 – Human Telomerase Reverse Transcriptase Core Promoter G-rich Region (hTERT_WT) DNA

Human Telomerase Reverse Transcriptase Core Promoter G-rich Region experimental SAS data

Sample:	Human Telomerase Reverse Transcriptase Core Promoter G-rich Region monomer, 22 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Oct 5

The hTERT core promoter forms three parallel G-quadruplexes. Nucleic Acids Res (2020)
Monsen RC, DeLeeuw L, Dean WL, Gray RD, Sabo TM, Chakravarthy S, Chaires JB, Trent JO

R_g^Guinier	2.2	nm
D_max	8.1	nm
Volume^Porod	28	nm³

SASDMJ6 – cMyc-8

cMyc promoter 8-tract G-quadruplex experimental SAS data

Sample:	cMyc promoter 8-tract G-quadruplex monomer, 11 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 19

Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
Monsen RC, DeLeeuw LW, Dean WL, Gray RD, Chakravarthy S, Hopkins JB, Chaires JB, Trent JO

R_g^Guinier	1.4	nm
D_max	4.6	nm
Volume^Porod	13	nm³

SASDHN3 – Antiparallel Hairpin (AH) DNA

Antiparallel Hairpin experimental SAS data

Sample:	Antiparallel Hairpin monomer, 21 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Nov 3

The hTERT core promoter forms three parallel G-quadruplexes. Nucleic Acids Res (2020)
Monsen RC, DeLeeuw L, Dean WL, Gray RD, Sabo TM, Chakravarthy S, Chaires JB, Trent JO

R_g^Guinier	2.5	nm
D_max	8.1	nm
Volume^Porod	28	nm³

SASDMM6 – cMyc-12

cMyc promoter 12-tract G-quadruplex experimental SAS data

cMyc promoter 12-tract G-quadruplex Kratky plot

Sample:	cMyc promoter 12-tract G-quadruplex monomer, 23 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 22

R_g^Guinier	2.3	nm
D_max	8.4	nm
Volume^Porod	29	nm³

SASDHP3 – Optimized Parallel DNA

Optimized Parallel experimental SAS data

Sample:	Optimized Parallel monomer, 18 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Nov 3

The hTERT core promoter forms three parallel G-quadruplexes. Nucleic Acids Res (2020)
Monsen RC, DeLeeuw L, Dean WL, Gray RD, Sabo TM, Chakravarthy S, Chaires JB, Trent JO

R_g^Guinier	1.7	nm
D_max	5.0	nm
Volume^Porod	17	nm³

SASDM36 – c-Myc12 DnaseI Treated G-quadruplex

c-Myc 12-tract G-quadruplex monomer Dnase I treated experimental SAS data

Sample:	c-Myc 12-tract G-quadruplex monomer Dnase I treated monomer, 22 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Sep 29

R_g^Guinier	2.0	nm
D_max	6.7	nm
Volume^Porod	25	nm³

SASDHQ3 – Human Telomerase Reverse Transcriptase Core Promoter (hTERT) PQS2-PQS3 region, WT_PQS23

hTERT core promoter PQS2-PQS3 region experimental SAS data

Sample:	hTERT core promoter PQS2-PQS3 region monomer, 14 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Nov 3

The hTERT core promoter forms three parallel G-quadruplexes. Nucleic Acids Res (2020)
Monsen RC, DeLeeuw L, Dean WL, Gray RD, Sabo TM, Chakravarthy S, Chaires JB, Trent JO

R_g^Guinier	1.7	nm
D_max	5.4	nm
Volume^Porod	18	nm³

SASDMK6 – cKit-8

cKit promoter 8-tract G-quadruplex experimental SAS data

Sample:	cKit promoter 8-tract G-quadruplex monomer, 12 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 19

R_g^Guinier	1.5	nm
D_max	4.7	nm
Volume^Porod	15	nm³

SASDHR3 – Antiparallel Hairpin PQS2-PQS3 segment DNA, AH_PQS23

Antiparallel Hairpin PQS2-PQS3 segment experimental SAS data

Sample:	Antiparallel Hairpin PQS2-PQS3 segment monomer, 14 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Nov 3

The hTERT core promoter forms three parallel G-quadruplexes. Nucleic Acids Res (2020)
Monsen RC, DeLeeuw L, Dean WL, Gray RD, Sabo TM, Chakravarthy S, Chaires JB, Trent JO

R_g^Guinier	2.0	nm
D_max	6.4	nm
Volume^Porod	18	nm³

SASDMN6 – cKit-12

cKit promoter 12-tract G-quadruplex experimental SAS data

Sample:	cKit promoter 12-tract G-quadruplex monomer, 20 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 22

R_g^Guinier	2.5	nm
D_max	9.0	nm
Volume^Porod	26	nm³

SASDM46 – c-Kit12 DNase I Digest

c-Kit 12-tract G-quadruplex monomer Dnase I treated experimental SAS data

c-Kit 12-tract G-quadruplex monomer Dnase I treated Kratky plot

Sample:	c-Kit 12-tract G-quadruplex monomer Dnase I treated monomer, 20 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Sep 29

R_g^Guinier	1.6	nm
D_max	5.7	nm
Volume^Porod	16	nm³

SASDML6 – kRas-8

kRas promoter 8-tract G-quadruplex experimental SAS data

Sample:	kRas promoter 8-tract G-quadruplex monomer, 14 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 19

R_g^Guinier	1.7	nm
D_max	5.6	nm
Volume^Porod	16	nm³

SASDM56 – 2KZD

TERT promoter G-quadruplex antiparallel experimental SAS data

Sample:	TERT promoter G-quadruplex antiparallel monomer, 6 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 13

R_g^Guinier	1.2	nm
D_max	3.6	nm
Volume^Porod	7	nm³

SASDM76 – 201D

DNA oligonucleotide G4(T4G4)3 experimental SAS data

Sample:	DNA oligonucleotide G4(T4G4)3 monomer, 9 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 12

R_g^Guinier	1.3	nm
D_max	4.1	nm
Volume^Porod	10	nm³

SASDM86 – 6GH0

cKIT 2-tetrad promoter GQ antiparallel experimental SAS data

Sample:	cKIT 2-tetrad promoter GQ antiparallel monomer, 7 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 21

R_g^Guinier	1.0	nm
D_max	3.1	nm
Volume^Porod	8	nm³

SASDM96 – 2GKU

human telomere 24mer hybrid-1 experimental SAS data

Sample:	human telomere 24mer hybrid-1 monomer, 8 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 11

R_g^Guinier	1.2	nm
D_max	3.8	nm
Volume^Porod	8	nm³

SASDMA6 – 5I2V

kRas promoter GQ hybrid experimental SAS data

Sample:	kRas promoter GQ hybrid monomer, 7 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20

R_g^Guinier	1.3	nm
D_max	4.9	nm
Volume^Porod	10	nm³

SASDMB6 – 6L92

WNT promoter GQ hybrid form experimental SAS data

Sample:	WNT promoter GQ hybrid form monomer, 7 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 21

R_g^Guinier	1.2	nm
D_max	3.9	nm
Volume^Porod	8	nm³

SASDMC6 – 2KQG

cKit promoter GQ parallel experimental SAS data

Sample:	cKit promoter GQ parallel monomer, 7 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20

R_g^Guinier	1.6	nm
D_max	3.2	nm
Volume^Porod	14	nm³

SASDMD6 – 2LBY

cMyc promoter GQ parallel experimental SAS data

Sample:	cMyc promoter GQ parallel monomer, 6 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20

R_g^Guinier	1.2	nm
D_max	3.9	nm
Volume^Porod	7	nm³

SASDME6 – 6NEB

cMyc promoter GQ 1:6:1 loop parallel experimental SAS data

Sample:	cMyc promoter GQ 1:6:1 loop parallel monomer, 9 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20

R_g^Guinier	1.4	nm
D_max	4.5	nm
Volume^Porod	10	nm³

SASDMF6 – 1XAV

cMyc promoter modified GQ parallel experimental SAS data

Sample:	cMyc promoter modified GQ parallel monomer, 7 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 11

R_g^Guinier	1.3	nm
D_max	4.1	nm
Volume^Porod	9	nm³

SASDM66 – 2KZE

TERT promoter G-quadruplex parallel experimental SAS data

Sample:	TERT promoter G-quadruplex parallel monomer, 6 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Aug 11

R_g^Guinier	1.3	nm
D_max	4.2	nm
Volume^Porod	8	nm³

SASDMG6 – 5CMX

two-tetrad antiparallel GQ with duplex junction experimental SAS data

Sample:	two-tetrad antiparallel GQ with duplex junction monomer, 10 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Oct 3

R_g^Guinier	1.5	nm
D_max	5.2	nm
Volume^Porod	12	nm³

SASDMH6 – 2M27

VEGF promoter GQ parallel experimental SAS data

Sample:	VEGF promoter GQ parallel monomer, 7 kDa synthetic construct DNA
Buffer:	6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20

R_g^Guinier	1.3	nm
D_max	3.8	nm
Volume^Porod	8	nm³

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