SASBDB entries for UniProt ID: Q6PHU5

SASDCW5 – Dimeric Sortilin at pH 7.4

UniProt ID: Q6PHU5 (None-None) Sortilin, also: Neurotensin-receptor 3
Sortilin, also: Neurotensin-receptor 3 experimental SAS data
DAMMIF model
Sample: Sortilin, also: Neurotensin-receptor 3 dimer, 153 kDa Mus musculus protein
Buffer: 25 mM HEPES pH 7.4, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2016 Apr 17
Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun 8(1):1708 (2017)
Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC
RgGuinier 3.9 nm
Dmax 11.0 nm
VolumePorod 275 nm3

SASDCX5 – Monomeric Sortilin at pH 5.5

UniProt ID: Q6PHU5 (None-None) Sortilin 1 A464E alias Neurotensin-receptor 3 A464E
Sortilin 1 A464E alias Neurotensin-receptor 3 A464E experimental SAS data
DAMMIF model
Sample: Sortilin 1 A464E alias Neurotensin-receptor 3 A464E monomer, 76 kDa Mus musculus protein
Buffer: 25 mM MES pH 5.5, 150 mM NaCl, pH: 5.5
Experiment: SAXS data collected at BM29, ESRF on 2016 Apr 17
Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun 8(1):1708 (2017)
Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC
RgGuinier 3.4 nm
Dmax 10.0 nm
VolumePorod 217 nm3

SASDCY5 – Dimeric Sortilin at pH 5.5

UniProt ID: Q6PHU5 (None-None) Sortilin, also: Neurotensin-receptor 3
Sortilin, also: Neurotensin-receptor 3 experimental SAS data
CORAL model
Sample: Sortilin, also: Neurotensin-receptor 3 dimer, 153 kDa Mus musculus protein
Buffer: 25 mM MES pH 5.5, 150 mM NaCl, pH: 5.5
Experiment: SAXS data collected at BM29, ESRF on 2016 Apr 17
Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun 8(1):1708 (2017)
Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC
RgGuinier 3.9 nm
Dmax 11.0 nm
VolumePorod 336 nm3

SASDCZ5 – Monomeric Sortilin at pH 7.4

UniProt ID: Q6PHU5 (None-None) Sortilin 1 A464E alias Neurotensin-receptor 3 A464E
Sortilin 1 A464E alias Neurotensin-receptor 3 A464E experimental SAS data
CORAL model
Sample: Sortilin 1 A464E alias Neurotensin-receptor 3 A464E monomer, 76 kDa Mus musculus protein
Buffer: 25 mM HEPES pH 7.4, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2016 Apr 17
Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun 8(1):1708 (2017)
Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC
RgGuinier 3.3 nm
Dmax 10.5 nm
VolumePorod 217 nm3

SASDCE7 – Monomeric Sortilin at pH 7.4 in the presence of neurotensin

UniProt ID: Q6PHU5 (None-None) Sortilin, also: Neurotensin-receptor 3
Sortilin, also: Neurotensin-receptor 3 experimental SAS data
Sortilin, also: Neurotensin-receptor 3 Kratky plot
Sample: Sortilin, also: Neurotensin-receptor 3 dimer, 153 kDa Mus musculus protein
Buffer: 25 mM HEPES pH 7.4, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2016 Apr 17
Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun 8(1):1708 (2017)
Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC
RgGuinier 3.3 nm
Dmax 11.7 nm
VolumePorod 192 nm3

SASDCF7 – Dimeric Sortilin at pH 7.4 in the presence of neurotensin

UniProt ID: Q6PHU5 (None-None) Sortilin, also: Neurotensin-receptor 3
Sortilin, also: Neurotensin-receptor 3 experimental SAS data
Sortilin, also: Neurotensin-receptor 3 Kratky plot
Sample: Sortilin, also: Neurotensin-receptor 3 dimer, 153 kDa Mus musculus protein
Buffer: 25 mM HEPES pH 7.4, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2016 Apr 17
Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun 8(1):1708 (2017)
Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC
RgGuinier 3.7 nm
Dmax 13.5 nm
VolumePorod 253 nm3