Browse by MODEL: Ab initio only

SASDTE2 – human CELSR1 EC4-7

Cadherin EGF LAG seven-pass G-type receptor 1 experimental SAS data
DAMFILT model
Sample: Cadherin EGF LAG seven-pass G-type receptor 1 monomer, 49 kDa Homo sapiens protein
Buffer: 20 mM Tris-HCl, 150 mM KCl, 50 mM NaCl, 2 mM CaCl2, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2021 Jul 1
CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain. Structure (2024)
Tamilselvan E, Sotomayor M
RgGuinier 4.9 nm
Dmax 16.9 nm
VolumePorod 85 nm3

SASDEU9 – Legionella pneumophila Phosphocholinase AnkX

Phosphocholinase AnkX experimental SAS data
GASBOR model
Sample: Phosphocholinase AnkX monomer, 107 kDa Legionella pneumophila protein
Buffer: 300 mM NaCl, 2 mM 2-mercaptoethanol and 30 mM Tris-HCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2017 Oct 20
Legionella pneumophila effector AnkX
Wenhua Zhang
RgGuinier 4.3 nm
Dmax 14.7 nm
VolumePorod 145 nm3

SASDR29 – Single-chain Archaeoglobus fulgidus argonaute fAfAgo-fusion variant in high salt buffer

single-chain full Archaeoglobus fulgidus Argonaute variant experimental SAS data
OTHER model
Sample: Single-chain full Archaeoglobus fulgidus Argonaute variant monomer, 78 kDa Archaeoglobus fulgidus protein
Buffer: 20 mM TrisHCl pH 7.5, 500 mM NaCl, 5 mM MgCl2, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 Aug 31
The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein. Nucleic Acids Res (2024)
Manakova E, Golovinas E, Pocevičiūtė R, Sasnauskas G, Silanskas A, Rutkauskas D, Jankunec M, Zagorskaitė E, Jurgelaitis E, Grybauskas A, Venclovas Č, Zaremba M
RgGuinier 3.1 nm
Dmax 9.7 nm
VolumePorod 142 nm3

SASDRB9 – Bruton's Tyrosine Kinase - full-length

Tyrosine-protein kinase BTK experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK monomer, 77 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 4.1 nm
Dmax 19.1 nm
VolumePorod 118 nm3

SASDRC9 – Bruton's Tyrosine Kinase - full-length with A384P, S386P, T387P, A388P and L390F mutations

Tyrosine-protein kinase BTK (A384P, S386P, T387P, A388P, L390F) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (A384P, S386P, T387P, A388P, L390F) monomer, 77 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 3.9 nm
Dmax 15.2 nm
VolumePorod 107 nm3

SASDRD9 – Bruton's Tyrosine Kinase - SH3-SH2-kinase domain

Tyrosine-protein kinase BTK (SH3-SH2-kinase domains) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (SH3-SH2-kinase domains) monomer, 52 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 2.4 nm
Dmax 7.5 nm
VolumePorod 68 nm3

SASDRE9 – Bruton's Tyrosine Kinase - SH3-SH2-kinase domain with A384P, S386P, T387P, A388P and L390F mutations

Tyrosine-protein kinase BTK (SH3-SH2-kinase domain A384P, S386P, T387P, A388P, L390F) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (SH3-SH2-kinase domain A384P, S386P, T387P, A388P, L390F) monomer, 53 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 2.5 nm
Dmax 7.8 nm
VolumePorod 71 nm3

SASDTL5 – Conjugal transfer accessory disulfide isomerase protein TrbB from the F plasmid (GST-fusion)

Protein TrbB (GST-fusion) experimental SAS data
DAMMIF model
Sample: Protein TrbB (GST-fusion) dimer, 93 kDa Escherichia coli (strain … protein
Buffer: 20 mM HEPES, 100 mM NaCl, 5% glycerol, 0.05% NP40, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 23
Structural insights into the disulfide isomerase and chaperone activity of TrbB of the F plasmid type IV secretion system Current Research in Structural Biology 8:100156 (2024)
Apostol A, Bragagnolo N, Rodriguez C, Audette G
RgGuinier 4.0 nm
Dmax 18.0 nm
VolumePorod 153 nm3

SASDKP6 – G-quadruplex DNA from Hepatitis B virus, wild type (HBV G4 WT)

HBV G4 WT experimental SAS data
DAMMIN model
Sample: HBV G4 WT monomer, 7 kDa Hepatitis B virus DNA
Buffer: 20 mM HEPES, 100 mM KCl, 1 mM EDTA, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Dec 15
HBV G-quad
Trushar Patel
RgGuinier 1.8 nm
Dmax 4.7 nm
VolumePorod 18 nm3

SASDKQ6 – G-quadruplex DNA from Hepatitis B virus, mutant (HBV G4 G1738A)

HBV G-quad G1738A experimental SAS data
DAMMIN model
Sample: HBV G-quad G1738A monomer, 7 kDa Hepatitis B virus DNA
Buffer: 20 mM HEPES, 100 mM KCl, 1 mM EDTA, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Sep 14
HBV G-quad
Trushar Patel
RgGuinier 1.9 nm
Dmax 5.3 nm
VolumePorod 21 nm3