Browse by ORGANISM: Homo sapiens (Human)

SASDEE7 – Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain at pH 6.5, 0.5 mM Calcium

Transient receptor potential channel mucolipin 2 experimental SAS data
CORAL model
Sample: Transient receptor potential channel mucolipin 2 tetramer, 93 kDa Homo sapiens protein
Buffer: 10 mM Hepes, pH 6.5, 150 mM NaCl, 0.5 mM CaCl2, pH: 6.5
Experiment: SAXS data collected at BM29, ESRF on 2018 Oct 20
Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain. Structure (2019)
Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA
RgGuinier 3.4 nm
Dmax 8.9 nm
VolumePorod 132 nm3

SASDEF7 – Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain at pH 6.5 without Calcium

Transient receptor potential channel mucolipin 2 experimental SAS data
CORAL model
Sample: Transient receptor potential channel mucolipin 2 tetramer, 93 kDa Homo sapiens protein
Buffer: 10 mM HEPES pH 6.5 150 mM NaCl, pH: 6.5
Experiment: SAXS data collected at BM29, ESRF on 2018 Oct 18
Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain. Structure (2019)
Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA
RgGuinier 3.4 nm
Dmax 8.9 nm
VolumePorod 140 nm3

SASDEG7 – Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain at pH 4.5 without Calcium

Transient receptor potential channel mucolipin 2 experimental SAS data
CORAL model
Sample: Transient receptor potential channel mucolipin 2 octamer, 187 kDa Homo sapiens protein
Buffer: 10 mM Hepes, pH 4.5, 150 mM NaCl, pH: 4.5
Experiment: SAXS data collected at BM29, ESRF on 2018 Oct 18
Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain. Structure (2019)
Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA
RgGuinier 3.7 nm
Dmax 10.0 nm
VolumePorod 285 nm3

SASDEH7 – Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain at pH 4.5, 0.5 mM Calcium

Transient receptor potential channel mucolipin 2 experimental SAS data
CORAL model
Sample: Transient receptor potential channel mucolipin 2 octamer, 187 kDa Homo sapiens protein
Buffer: 10 mM Hepes, pH 4.5, 150 mM NaCl, 0.5 mM CaCl2, pH: 4.5
Experiment: SAXS data collected at BM29, ESRF on 2018 Oct 20
Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain. Structure (2019)
Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA
RgGuinier 3.7 nm
Dmax 10.0 nm
VolumePorod 280 nm3

SASDDD7 – Apolipoprotein E2

Apolipoprotein E2 experimental SAS data
Apolipoprotein E2 Kratky plot
Sample: Apolipoprotein E2 tetramer, 139 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Nov 29
The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease. J Mol Biol (2019)
Raulin AC, Kraft L, Al-Hilaly YK, Xue WF, McGeehan JE, Atack JR, Serpell L
RgGuinier 5.6 nm
Dmax 19.5 nm
VolumePorod 400 nm3

SASDD98 – Apolipoprotein E3

Apolipoprotein E3 experimental SAS data
Apolipoprotein E3 Kratky plot
Sample: Apolipoprotein E3 tetramer, 139 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Nov 29
The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease. J Mol Biol (2019)
Raulin AC, Kraft L, Al-Hilaly YK, Xue WF, McGeehan JE, Atack JR, Serpell L
RgGuinier 5.7 nm
Dmax 19.5 nm
VolumePorod 410 nm3

SASDDA8 – Apolipoprotein E4

Apolipoprotein E4 experimental SAS data
Apolipoprotein E4 Kratky plot
Sample: Apolipoprotein E4 tetramer, 139 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Nov 29
The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease. J Mol Biol (2019)
Raulin AC, Kraft L, Al-Hilaly YK, Xue WF, McGeehan JE, Atack JR, Serpell L
RgGuinier 5.8 nm
Dmax 19.6 nm
VolumePorod 430 nm3

SASDFU3 – Lysine-specific Demethylase (LSD2)

Lysyne-specific Demethylase LSD2 experimental SAS data
Lysyne-specific Demethylase LSD2 Kratky plot
Sample: Lysyne-specific Demethylase LSD2 monomer, 89 kDa Homo sapiens protein
Buffer: 15 mM HEPES, 200 mM NaCl, pH: 7.3
Experiment: SAXS data collected at BM29, ESRF on 2017 Dec 11
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep 27(2):387-399.e7 (2019)
Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A
RgGuinier 3.4 nm
Dmax 10.6 nm
VolumePorod 124 nm3

SASDFV3 – Cytokine-like nuclear factor dehydrogenase domain, NPAC DH (NPAC delta-261)

NPAC dehydrogenase domain experimental SAS data
NPAC dehydrogenase domain Kratky plot
Sample: NPAC dehydrogenase domain tetramer, 125 kDa Homo sapiens protein
Buffer: 15 mM HEPES, 200 mM NaCl, pH: 7.3
Experiment: SAXS data collected at BM29, ESRF on 2018 Jan 26
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep 27(2):387-399.e7 (2019)
Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A
RgGuinier 3.5 nm
Dmax 11.0 nm
VolumePorod 167 nm3

SASDFW3 – Cytokine-like nuclear factor dehydrogenase domain, NPAC DH, plus native linker (NPAC delta-205)

NPAC linker+DH (delta-205) experimental SAS data
NPAC linker+DH (delta-205) Kratky plot
Sample: NPAC linker+DH (delta-205) tetramer, 150 kDa Homo sapiens protein
Buffer: 15 mM HEPES, 200 mM NaCl, pH: 7.3
Experiment: SAXS data collected at BM29, ESRF on 2018 Jan 26
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep 27(2):387-399.e7 (2019)
Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A
RgGuinier 4.0 nm
Dmax 11.4 nm
VolumePorod 240 nm3