Small Angle Scattering Biological Data Bank SASBDB

Browse by ORGANISM: Homo sapiens (Human)

SASDB32 – Human Filamin A Ig-like domains 16-17 truncation (1782-1956)

Human Filamin A Ig-like domains 16-17 experimental SAS data

Sample:	Human Filamin A Ig-like domains 16-17 monomer, 19 kDa Homo sapiens protein
Buffer:	20 mM Tris 50 mM NaCl 10 mM DTT, pH:
Experiment:	SAXS data collected at BM29, ESRF on 2013 Sep 30

Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing. Sci Rep 7(1):4218 (2017)
Seppälä J, Bernardi RC, Haataja TJK, Hellman M, Pentikäinen OT, Schulten K, Permi P, Ylänne J, Pentikäinen U

R_g^Guinier	1.8	nm
D_max	6.2	nm
Volume^Porod	31	nm³

SASDB42 – Human Filamin A Ig-like domains 16-17* truncation (1782-1956) L1788R patient mutation

Sample:	Human Filamin A Ig-like domains 16-17* monomer, 19 kDa Homo sapiens protein
Buffer:	20 mM Tris 50 mM NaCl 10 mM DTT, pH:
Experiment:	SAXS data collected at BM29, ESRF on 2013 Sep 30

R_g^Guinier	2.4	nm
D_max	8.3	nm
Volume^Porod	37	nm³

SASDBM6 – Nucleolysin TIA-1 isoform p40

Nucleolysin TIA-1 isoform p40 experimental SAS data

Nucleolysin TIA-1 isoform p40 Kratky plot

Sample:	Nucleolysin TIA-1 isoform p40 monomer, 21 kDa Homo sapiens protein
Buffer:	20 mM HEPES, 100 mM NaCl, 3% v/v glycerol, pH: 7
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2015 Jul 2

TIA-1 RRM23 binding and recognition of target oligonucleotides. Nucleic Acids Res 45(8):4944-4957 (2017)
Waris S, García-Mauriño SM, Sivakumaran A, Beckham SA, Loughlin FE, Gorospe M, Díaz-Moreno I, Wilce MCJ, Wilce JA

R_g^Guinier	2.3	nm
D_max	8.8	nm
Volume^Porod	26	nm³

SASDBN6 – Nucleolysin TIA-1 isoform p40 in complex with ACUCCUUUUU RNA

Nucleolysin TIA-1 isoform p40RNA (ACUCCUUUUU) experimental SAS data

Nucleolysin TIA-1 isoform p40 RNA (ACUCCUUUUU) Kratky plot

Sample:	Nucleolysin TIA-1 isoform p40 monomer, 21 kDa Homo sapiens protein RNA (ACUCCUUUUU) monomer, 1 kDa RNA
Buffer:	20 mM HEPES, 100 mM NaCl, 3% v/v glycerol, pH: 7
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2016 May 27

R_g^Guinier	2.2	nm
D_max	6.6	nm
Volume^Porod	30	nm³

SASDBP6 – Nucleolysin TIA-1 isoform p40 in complex with ACTCCTTTTT DNA

Nucleolysin TIA-1 isoform p40DNA (ACTCCTTTTT) experimental SAS data

Nucleolysin TIA-1 isoform p40 DNA (ACTCCTTTTT) Kratky plot

Sample:	Nucleolysin TIA-1 isoform p40 monomer, 21 kDa Homo sapiens protein DNA (ACTCCTTTTT) monomer, 1 kDa DNA
Buffer:	20 mM HEPES, 100 mM NaCl, 3% v/v glycerol, pH: 7
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2016 May 27

R_g^Guinier	2.2	nm
D_max	6.7	nm
Volume^Porod	32	nm³

SASDBQ6 – Nucleolysin TIA-1 isoform p40 in complex with TTTTTACTCC DNA

Nucleolysin TIA-1 isoform p40DNA (TTTTTACTCC) experimental SAS data

Nucleolysin TIA-1 isoform p40 DNA (TTTTTACTCC) Kratky plot

Sample:	Nucleolysin TIA-1 isoform p40 monomer, 21 kDa Homo sapiens protein DNA (TTTTTACTCC) monomer, 1 kDa DNA
Buffer:	20 mM HEPES, 100 mM NaCl, 3% v/v glycerol, pH: 7
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2016 May 27

R_g^Guinier	2.1	nm
D_max	7.1	nm
Volume^Porod	32	nm³

SASDBR6 – Nucleolysin TIA-1 isoform p40 in complex with UUUUUACUCC RNA

Nucleolysin TIA-1 isoform p40RNA (UUUUUACU) experimental SAS data

Nucleolysin TIA-1 isoform p40 RNA (UUUUUACU) Kratky plot

Sample:	Nucleolysin TIA-1 isoform p40 monomer, 21 kDa Homo sapiens protein RNA (UUUUUACU) monomer, 1 kDa RNA
Buffer:	20 mM HEPES, 100 mM NaCl, 3% v/v glycerol, pH: 7
Experiment:	SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2016 May 27

R_g^Guinier	2.1	nm
D_max	6.5	nm
Volume^Porod	26	nm³

SASDB59 – Recombinant monomeric human Properdin

Human recombinant Properdin TSR 0-3Human recombinant Properdin TSR 4-6 experimental SAS data

Sample:	Human recombinant Properdin TSR 0-3 monomer, 25 kDa Homo sapiens protein Human recombinant Properdin TSR 4-6 monomer, 24 kDa Homo sapiens protein
Buffer:	10 mM HEPES 150 mM NaCl, pH: 7.2
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2015 Aug 16

Functional and structural insight into properdin control of complement alternative pathway amplification. EMBO J 36(8):1084-1099 (2017)
Pedersen DV, Roumenina L, Jensen RK, Gadeberg TA, Marinozzi C, Picard C, Rybkine T, Thiel S, Sørensen UB, Stover C, Fremeaux-Bacchi V, Andersen GR

R_g^Guinier	5.1	nm
D_max	18.0	nm

SASDB69 – E244K monomeric human Properdin

E244K Human Properdin experimental SAS data

Sample:	E244K Human Properdin monomer, 49 kDa Homo sapiens protein
Buffer:	10 mM HEPES 150 mM NaCl, pH: 7.2
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2016 Jul 27

R_g^Guinier	4.1	nm
D_max	15.0	nm

SASDB99 – Extracellular assembly of the human TSLP:TSLPR:IL-7Ralpha complex

Thymic stromal lymphopoietinInterleukin-7 receptor subunit alphaCytokine receptor-like factor 2 experimental SAS data

Sample:	Thymic stromal lymphopoietin monomer, 15 kDa Homo sapiens protein Interleukin-7 receptor subunit alpha monomer, 26 kDa Homo sapiens protein Cytokine receptor-like factor 2 monomer, 24 kDa Homo sapiens protein
Buffer:	10 mM Hepes, 150 mM NaCl, pH: 7.4
Experiment:	SAXS data collected at SWING, SOLEIL on 2016 Apr 8

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma. Nat Commun 8:14937 (2017)
Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN

R_g^Guinier	3.1	nm
D_max	10.3	nm
Volume^Porod	98	nm³

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