Browse by ORGANISM: Homo sapiens (Human)

SASDBR2 – Contactin-associated protein-like 2 (Caspr2) extracellular domains 1-1261.

Contactin-associated protein-like 2 extracellular domains (1-1261) experimental SAS data
DAMMIN model
Sample: Contactin-associated protein-like 2 extracellular domains (1-1261) monomer, 140 kDa Homo sapiens protein
Buffer: 10 mM HEPES 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at Anton Paar SAXSess, University of Utah on 2010 Oct 4
Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1. J Biol Chem 291(11):5788-802 (2016)
Rubio-Marrero EN, Vincelli G, Jeffries CM, Shaikh TR, Pakos IS, Ranaivoson FM, von Daake S, Demeler B, De Jaco A, Perkins G, Ellisman MH, Trewhella J, Comoletti D
RgGuinier 4.4 nm
Dmax 14.5 nm
VolumePorod 282 nm3

SASDBT2 – Ankyrin repeat domains from human Tankyrase-2 (489-649)

Ankyrin repeat domains from Tankyrase 2 experimental SAS data
Ankyrin repeat domains from Tankyrase 2 Kratky plot
Sample: Ankyrin repeat domains from Tankyrase 2 monomer, 18 kDa Homo sapiens protein
Buffer: 50 mM HEPES 100mM NaCl 1mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2014 Dec 4
Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope. Structure 24(2):252-60 (2016)
Fetics S, Thureau A, Campanacci V, Aumont-Nicaise M, Dang I, Gautreau A, Pérez J, Cherfils J
RgGuinier 1.8 nm
Dmax 6.3 nm
VolumePorod 24 nm3

SASDBU2 – Human Arpin (isoform 1)

Human Arpin experimental SAS data
Human Arpin Kratky plot
Sample: Human Arpin monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES 100mM NaCl 1mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2014 Dec 4
Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope. Structure 24(2):252-60 (2016)
Fetics S, Thureau A, Campanacci V, Aumont-Nicaise M, Dang I, Gautreau A, Pérez J, Cherfils J
RgGuinier 2.6 nm
Dmax 13.2 nm
VolumePorod 47 nm3

SASDBX2 – Zebrafish Arpin in complex with the ankyrin repeat domains of human Tankyrase 2 (489-469)

Zebrafish arpin/human tankyrase 2 ankyrin repeat domain complex experimental SAS data
Zebrafish arpin/human tankyrase 2 ankyrin repeat domain complex Kratky plot
Sample: Zebrafish arpin/human tankyrase 2 ankyrin repeat domain complex monomer, 43 kDa Danio rerio / … protein
Buffer: 50 mM HEPES 100mM NaCl 1mM TCEP, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2014 Dec 4
Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope. Structure 24(2):252-60 (2016)
Fetics S, Thureau A, Campanacci V, Aumont-Nicaise M, Dang I, Gautreau A, Pérez J, Cherfils J
RgGuinier 3.3 nm
Dmax 12.6 nm
VolumePorod 58 nm3

SASDB25 – Cardiac myosin binding protein-C: domains C5-C6-C7

Cardiac myosin binding protein-C: domains C5-C6-C7 experimental SAS data
Cardiac myosin binding protein-C: domains C5-C6-C7 Kratky plot
Sample: Cardiac myosin binding protein-C: domains C5-C6-C7 monomer, 36 kDa Homo sapiens protein
Buffer: 25 mM Tris-HCl, 250 mM NaCl, 2 mM TCEP, 0.02% sodium azide, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2015 Apr 18
Clinically Linked Mutations in the Central Domains of Cardiac Myosin-Binding Protein C with Distinct Phenotypes Show Differential Structural Effects. Structure 24(1):105-115 (2016)
Nadvi NA, Michie KA, Kwan AH, Guss JM, Trewhella J
RgGuinier 3.8 nm
Dmax 14.1 nm
VolumePorod 55 nm3

SASDBW3 – Human calumenin (sarco-endoplasmic reticulum calcium-sensing protein)

Human Calumenin experimental SAS data
Human Calumenin Kratky plot
Sample: Human Calumenin monomer, 29 kDa Homo sapiens protein
Buffer: 25 mM Na-HEPES, 25 mM NaCl, 2.5 mM CaCl2, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2016 Feb 12
Ca-Dependent Folding of Human Calumenin. PLoS One 11(3):e0151547 (2016)
Mazzorana M, Hussain R, Sorensen T
RgGuinier 2.3 nm
Dmax 6.5 nm
VolumePorod 49 nm3

SASDCH2 – Aldehyde dehydrogenase 7A1

Aldehyde dehydrogenase 7A1 (Alpha-aminoadipic semialdehyde dehydrogenase) experimental SAS data
NONE model
Sample: Aldehyde dehydrogenase 7A1 (Alpha-aminoadipic semialdehyde dehydrogenase) tetramer, 222 kDa Homo sapiens protein
Buffer: 50 mM Tris, 5% glycerol, 0.5 mM tris(3-hydroxypropyl)phosphine, 50 mM NaCl, pH: 7.8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2014 Mar 9
Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1. Biochemistry 54(35):5513-22 (2015)
Luo M, Tanner JJ
RgGuinier 3.8 nm
Dmax 11.5 nm
VolumePorod 270 nm3

SASDAR6 – human CSF-1:CSF-1R extracellular signalling complex

Macrophage colony-stimulating factor 1Macrophage colony-stimulating factor 1 receptor experimental SAS data
SASREF model
Sample: Macrophage colony-stimulating factor 1 dimer, 35 kDa Homo sapiens protein
Macrophage colony-stimulating factor 1 receptor dimer, 107 kDa Homo sapiens protein
Buffer: 50 mM NaH2PO4, 100 m, pH: 7.4
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Mar 13
Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure 23(9):1621-1631 (2015)
Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN
RgGuinier 5.7 nm
Dmax 17.9 nm
VolumePorod 299 nm3

SASDA38 – transglutaminase-2 (TGA2)

transglutaminase 2 experimental SAS data
CRYSOL model
Sample: Transglutaminase 2 monomer, 79 kDa Homo sapiens protein
Buffer: 20 mM Tris 150mM NaCl 1mM EDTA, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Jan 17
Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease. J Biol Chem 290(35):21365-75 (2015)
Chen X, Hnida K, Graewert MA, Andersen JT, Iversen R, Tuukkanen A, Svergun D, Sollid LM
RgGuinier 3.4 nm
Dmax 12.0 nm
VolumePorod 117 nm3

SASDA48 – transglutaminase2:anti-transglutaminase2 FAB1 antibody complex

anti-TG2 antibody (679 14 E06) transglutaminase 2 experimental SAS data
DAMMIN model
Sample: Anti-TG2 antibody (679 14 E06) monomer, 48 kDa protein
Transglutaminase 2 monomer, 79 kDa Homo sapiens protein
Buffer: 20 mM Tris 150mM NaCl 1mM EDTA, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Jan 17
Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease. J Biol Chem 290(35):21365-75 (2015)
Chen X, Hnida K, Graewert MA, Andersen JT, Iversen R, Tuukkanen A, Svergun D, Sollid LM
RgGuinier 4.0 nm
Dmax 13.9 nm
VolumePorod 168 nm3