Browse by ORGANISM: Homo sapiens (Human)

SASDSQ6 – Human RAD23B, ∆UBA-1 domain deletion (RAD23B∆UBA1)

UV excision repair protein RAD23 homolog B (∆186-231) experimental SAS data
UV excision repair protein RAD23 homolog B (∆186-231) Kratky plot
Sample: UV excision repair protein RAD23 homolog B (∆186-231) monomer, 38 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 22
Domain deletion constructs of hHR23B
Sarasi Galagedera
RgGuinier 4.6 nm
Dmax 21.7 nm
VolumePorod 95 nm3

SASDSR6 – Human RAD23B, ∆UBA-2 domain deletion (RAD23B∆UBA2)

UV excision repair protein RAD23 homolog B (∆362-409) experimental SAS data
UV excision repair protein RAD23 homolog B (∆362-409) Kratky plot
Sample: UV excision repair protein RAD23 homolog B (∆362-409) monomer, 38 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 22
Domain deletion constructs of hHR23B
Sarasi Galagedera
RgGuinier 4.1 nm
Dmax 17.5 nm
VolumePorod 79 nm3

SASDSS6 – Human RAD23B, ∆STI1 domain deletion (RAD23B∆STI1)

UV excision repair protein RAD23 homolog B (∆274-306) experimental SAS data
UV excision repair protein RAD23 homolog B (∆274-306) Kratky plot
Sample: UV excision repair protein RAD23 homolog B (∆274-306) monomer, 39 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 22
Domain deletion constructs of hHR23B
Sarasi Galagedera
RgGuinier 4.6 nm
Dmax 24.2 nm
VolumePorod 103 nm3

SASDST6 – Human RAD23B with ∆UBA-1 and ∆UBA-2 domain deletions (RAD23B∆UBA1∆UBA2)

UV excision repair protein RAD23 homolog B (∆186-231, ∆362-409) experimental SAS data
UV excision repair protein RAD23 homolog B (∆186-231, ∆362-409) Kratky plot
Sample: UV excision repair protein RAD23 homolog B (∆186-231, ∆362-409) monomer, 33 kDa Homo sapiens protein
Buffer: 20 mM sodium phosphate, 0.5 mM EDTA, 0.02 % NaN3, pH: 6.8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Feb 22
Domain deletion constructs of hHR23B
Sarasi Galagedera
RgGuinier 4.9 nm
Dmax 25.5 nm
VolumePorod 100 nm3

SASDSW5 – B cell lymphoma 7 protein family member A (BCL7A)

Isoform 2 of B-cell CLL/lymphoma 7 protein family member A experimental SAS data
Isoform 2 of B-cell CLL/lymphoma 7 protein family member A Kratky plot
Sample: Isoform 2 of B-cell CLL/lymphoma 7 protein family member A monomer, 25 kDa Homo sapiens protein
Buffer: 20 mM Tris-HCl , 50 mM KCl, 1 mM DTT, pH: 8
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Dec 2
BCL7 proteins, novel subunits of the mammalian SWI/SNF complex, bind the nucleosome core particle
Asgar Abbas kazrani
RgGuinier 4.8 nm
Dmax 28.8 nm

SASDSY5 – Nucleosome (NCP) in complex with B cell lymphoma 7 protein family member A (BCL7A)

Isoform 2 of B-cell CLL/lymphoma 7 protein family member AHistone H3.2Histone H4Histone H2AHistone H2B 1.1Widom 601 DNA sequence experimental SAS data
EOM/RANCH model
Sample: Isoform 2 of B-cell CLL/lymphoma 7 protein family member A monomer, 25 kDa Homo sapiens protein
Histone H3.2 dimer, 31 kDa Xenopus laevis protein
Histone H4 dimer, 23 kDa Xenopus laevis protein
Histone H2A dimer, 28 kDa Xenopus laevis protein
Histone H2B 1.1 dimer, 28 kDa Xenopus laevis protein
Widom 601 DNA sequence dimer, 89 kDa Escherichia coli DNA
Buffer: 20 mM Tris-HCl , 50 mM KCl, 1 mM DTT, pH: 8
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Dec 2
BCL7 proteins, novel subunits of the mammalian SWI/SNF complex, bind the nucleosome core particle
Asgar Abbas kazrani
RgGuinier 4.7 nm
Dmax 24.4 nm
VolumePorod 400 nm3

SASDVQ9 – Full-length mature human mitochondrial ATP synthase subunit O (Oligomycin Sensitivity Conferral Protein or Complex V subunit O)

ATP synthase subunit O, mitochondrial experimental SAS data
ALPHAFOLD model
Sample: ATP synthase subunit O, mitochondrial dimer, 42 kDa Homo sapiens protein
Buffer: 50 mM Na2HPO4, 300 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2022 Mar 15
The OSCP Subunit of ATP Synthase is a Dimer in Solution: Strategy to Induce the Monomeric Protein as a New Tool for Drug Discovery. J Mol Biol 437(17):169267 (2025)
Fabbian S, Gabbatore L, Morbiato L, Zotti M, Giorgio V, Battisutta R, Giachin G, Sosic A, Bellanda M
RgGuinier 3.7 nm
Dmax 12.0 nm
VolumePorod 78 nm3

SASDVR9 – C-terminal tail of human mitochondrial ATP synthase subunit O (137-213) (Oligomycin Sensitivity Conferral Protein or Complex V subunit O)

ATP synthase subunit O, mitochondrial C-terminal section experimental SAS data
ALPHAFOLD model
Sample: ATP synthase subunit O, mitochondrial C-terminal section trimer, 25 kDa Homo sapiens protein
Buffer: 50 mM Na2HPO4, 300 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2022 Mar 15
The OSCP Subunit of ATP Synthase is a Dimer in Solution: Strategy to Induce the Monomeric Protein as a New Tool for Drug Discovery. J Mol Biol 437(17):169267 (2025)
Fabbian S, Gabbatore L, Morbiato L, Zotti M, Giorgio V, Battisutta R, Giachin G, Sosic A, Bellanda M
RgGuinier 2.1 nm
Dmax 6.5 nm
VolumePorod 32 nm3

SASDWG9 – PDZ domain of the segment polarity protein dishevelled homolog DVL-3

Segment polarity protein dishevelled homolog DVL-3 experimental SAS data
REFMAC model
Sample: Segment polarity protein dishevelled homolog DVL-3 monomer, 12 kDa Homo sapiens protein
Buffer: 50 mM sodium phosphate, 50 mM NaCl, 0.5 mM EDTA, pH: 6.5
Experiment: SAXS data collected at Rigaku BioSAXS-2000, CEITEC on 2021 Jan 27
A class III ligand oscillates between internal and terminal binding modes as it engages with the Dishevelled PDZ domain. Structure (2025)
Kumar J, Micka M, Komárek J, Klumpler T, Bystrý V, Sprangers R, Bařinka C, Bryja V, Tripsianes K
RgGuinier 1.6 nm
Dmax 4.3 nm
VolumePorod 20 nm3

SASDUC3 – Phosphorylated E3 ubiquitin-protein ligase Nedd4-2 in the absence of calcium

Isoform 5 of E3 ubiquitin-protein ligase NEDD4-like experimental SAS data
CORAL model
Sample: Isoform 5 of E3 ubiquitin-protein ligase NEDD4-like monomer, 110 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, 3% glycerol, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Aug 17
Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins Nature Communications 16(1) (2025)
Janosev M, Kosek D, Tekel A, Joshi R, Honzejkova K, Pohl P, Obsil T, Obsilova V
RgGuinier 4.9 nm
Dmax 22.0 nm
VolumePorod 206 nm3