Browse by ORGANISM: other species

SASDN37 – ASO2 DNA in the presence of target RNA

MOE PS gapmers 3-8-3PSCK9, 24mer ASO binding site experimental SAS data
DAMMIF model
Sample: MOE PS gapmers 3-8-3 monomer, 4 kDa DNA
PSCK9, 24mer ASO binding site monomer, 8 kDa RNA
Buffer: phosphate buffered saline, pH: 7.4
Experiment: SAXS data collected at B21, Diamond Light Source on 2021 Oct 21
Application of enhanced biophysical strategies to determine ASO/target RNA binding affinity and kinetics
Michael Lerche
RgGuinier 2.1 nm
Dmax 6.4 nm
VolumePorod 16 nm3

SASDN47 – ASO3 RNA in the presence of target RNA

oME ASOPSCK9, 24mer ASO binding site experimental SAS data
oME ASO PSCK9, 24mer ASO binding site Kratky plot
Sample: OME ASO monomer, 4 kDa RNA
PSCK9, 24mer ASO binding site monomer, 8 kDa RNA
Buffer: phosphate buffered saline, pH: 7.4
Experiment: SAXS data collected at B21, Diamond Light Source on 2021 Oct 21
Application of enhanced biophysical strategies to determine ASO/target RNA binding affinity and kinetics
Michael Lerche
RgGuinier 1.9 nm
Dmax 6.2 nm
VolumePorod 16 nm3

SASDVT5 – Marchantia polymorpha Auxin Response Factor 3

Auxin response factor experimental SAS data
GASBOR model
Sample: Auxin response factor monomer, 46 kDa Marchantia polymorpha protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, pH: 8
Experiment: SAXS data collected at BL11 - NCD, ALBA on 2019 Dec 3
The structure and function of the DNA binding domain of class B MpARF2 share more traits with class A AtARF5 than to that of class B AtARF1. Structure (2025)
Crespo I, Malfois M, Rienstra J, Tarrés-Solé A, van den Berg W, Weijers D, Boer DR
RgGuinier 2.6 nm
Dmax 6.2 nm
VolumePorod 59 nm3

SASDVU5 – Marchantia polymorpha Auxin Response Factor 3 in complex with high affinity DNA

Auxin response factorHigh Affinity ARF binding sequence inverted repeat with 6 nucleotide spacing experimental SAS data
SWISSMODEL model
Sample: Auxin response factor monomer, 46 kDa Marchantia polymorpha protein
High Affinity ARF binding sequence inverted repeat with 6 nucleotide spacing dimer, 12 kDa DNA
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, pH: 8
Experiment: SAXS data collected at BL11 - NCD, ALBA on 2019 Dec 3
The structure and function of the DNA binding domain of class B MpARF2 share more traits with class A AtARF5 than to that of class B AtARF1. Structure (2025)
Crespo I, Malfois M, Rienstra J, Tarrés-Solé A, van den Berg W, Weijers D, Boer DR
RgGuinier 3.1 nm
Dmax 8.4 nm
VolumePorod 67 nm3

SASDVC8 – Hendra virus protein P/V/W PNT3 domain

Protein W experimental SAS data
Hendra virus protein P/V/W PNT3 domain Rg histogram
Sample: Protein W monomer, 15 kDa Hendra virus (isolate … protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2023 Jun 13
Unraveling the molecular grammar and the structural transitions underlying the fibrillation of a viral fibrillogenic domain. Protein Sci 34(3):e70068 (2025)
Gondelaud F, Leval J, Arora L, Walimbe A, Bignon C, Ptchelkine D, Brocca S, Mukhopadyay S, Longhi S
RgGuinier 3.4 nm
Dmax 13.5 nm
VolumePorod 42 nm3

SASDVD8 – Hendra virus protein P/V/W PNT3 low-K domain

Protein W (artificial PNT3 variant - low-kappa) experimental SAS data
Hendra virus protein P/V/W PNT3 low-K domain Rg histogram
Sample: Protein W (artificial PNT3 variant - low-kappa) monomer, 15 kDa Hendra virus (isolate … protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2023 Jun 13
Unraveling the molecular grammar and the structural transitions underlying the fibrillation of a viral fibrillogenic domain. Protein Sci 34(3):e70068 (2025)
Gondelaud F, Leval J, Arora L, Walimbe A, Bignon C, Ptchelkine D, Brocca S, Mukhopadyay S, Longhi S
RgGuinier 3.8 nm
Dmax 18.0 nm
VolumePorod 48 nm3

SASDVE8 – Hendra virus protein P/V/W PNT3 high-K domain

Protein W (artificial PNT3 variant - high-kappa) experimental SAS data
Hendra virus protein P/V/W PNT3 high-K domain Rg histogram
Sample: Protein W (artificial PNT3 variant - high-kappa) monomer, 15 kDa Hendra virus (isolate … protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at SWING, SOLEIL on 2024 Apr 5
Unraveling the molecular grammar and the structural transitions underlying the fibrillation of a viral fibrillogenic domain. Protein Sci 34(3):e70068 (2025)
Gondelaud F, Leval J, Arora L, Walimbe A, Bignon C, Ptchelkine D, Brocca S, Mukhopadyay S, Longhi S
RgGuinier 3.1 nm
Dmax 14.7 nm
VolumePorod 54 nm3

SASDVX3 – Desulfofustis sp. PB-SRB1 ligand-gated ion channel DeCLIC with calcium at pH 5 by paused SEC-SANS

Neurotransmitter-gated ion-channel ligand-binding domain-containing protein experimental SAS data
Desulfofustis sp. PB-SRB1 ligand-gated ion channel DeCLIC with calcium at pH 5 by paused SEC-SANS Rg histogram
Sample: Neurotransmitter-gated ion-channel ligand-binding domain-containing protein pentamer, 342 kDa Desulfofustis sp. PB-SRB1 protein
Buffer: 20 mM citrate, 150 mM NaCl, 10 mM CaCl2, 0.5 mM deuterated n-Dodecyl-B-D-Maltoside, in D2O, pH: 5
Experiment: SANS data collected at D22, Institut Laue-Langevin (ILL) on 2021 Jun 17
Structural characterization of pH-modulated closed and open states in a pentameric ligand-gated ion channel
Marie Lycksell
RgGuinier 5.1 nm
Dmax 17.1 nm
VolumePorod 581 nm3

SASDVY3 – Desulfofustis sp. PB-SRB1 ligand-gated ion channel DeCLIC without calcium at pH 5 by paused SEC-SANS

Neurotransmitter-gated ion-channel ligand-binding domain-containing protein experimental SAS data
Desulfofustis sp. PB-SRB1 ligand-gated ion channel DeCLIC without calcium at pH 5 by paused SEC-SANS Rg histogram
Sample: Neurotransmitter-gated ion-channel ligand-binding domain-containing protein pentamer, 342 kDa Desulfofustis sp. PB-SRB1 protein
Buffer: 20 mM citrate, 150 mM NaCl, 10 mM EDTA, 0.5 mM deuterated n-Dodecyl-β-D-Maltoside, in D2O, pH: 5
Experiment: SANS data collected at D22, Institut Laue-Langevin (ILL) on 2021 Jun 17
Structural characterization of pH-modulated closed and open states in a pentameric ligand-gated ion channel
Marie Lycksell
RgGuinier 5.2 nm
Dmax 18.4 nm
VolumePorod 558 nm3

SASDWF4 – Outer membrane protein MIP from Legionella pneumophila (LpMIP) in complex with inhibitor NJS224

Outer membrane protein MIP(2S)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐4‐methyl‐N‐[(pyridin‐3‐ yl)methyl]pentanamide experimental SAS data
SREFLEX model
Sample: Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
(2S)‐2‐{[(2S)‐1‐[(4‐ fluorophenyl)methanesulfonyl]piperidin‐2‐ yl]formamido}‐4‐methyl‐N‐[(pyridin‐3‐ yl)methyl]pentanamide monomer, 1 kDa
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Nov 22
Structure and Dynamics of Macrophage Infectivity Potentiator Proteins from Pathogenic Bacteria and Protozoans Bound to Fluorinated Pipecolic Acid Inhibitors. J Med Chem (2025)
Pérez Carrillo VH, Whittaker JJ, Wiedemann C, Harder JM, Lohr T, Jamithireddy AK, Dajka M, Goretzki B, Joseph B, Guskov A, Harmer NJ, Holzgrabe U, Hellmich UA
RgGuinier 2.9 nm
Dmax 9.7 nm
VolumePorod 61 nm3