Small Angle Scattering Biological Data Bank SASBDB

SASBDB entries for UniProt ID:

SASDB43 – Human dystrophin central domain repeats 1 to 2

UniProt ID: P11532 (338-563) Dystrophin central domain repeats 1 to 2

Dystrophin central domain repeats 1 to 2 experimental SAS data

Sample:	Dystrophin central domain repeats 1 to 2 monomer, 26 kDa Homo sapiens protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM EDTA 2% glycerol, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2011 Oct 7

Dystrophin's central domain forms a complex filament that becomes disorganized by in-frame deletions. J Biol Chem 293(18):6637-6646 (2018)
Delalande O, Molza AE, Dos Santos Morais R, Chéron A, Pollet É, Raguenes-Nicol C, Tascon C, Giudice E, Guilbaud M, Nicolas A, Bondon A, Leturcq F, Férey N, Baaden M, Perez J, Roblin P, Piétri-Rouxel F, Hubert JF, Czjzek M, Le Rumeur E

R_g^Guinier	3.0	nm
D_max	10.6	nm
Volume^Porod	42	nm³

SASDB53 – Human dystrophin central domain repeats 1 to 3

UniProt ID: P11532 (338-668) Dystrophin central domain repeats 1 to 3

Dystrophin central domain repeats 1 to 3 experimental SAS data

Sample:	Dystrophin central domain repeats 1 to 3 monomer, 38 kDa Homo sapiens protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM EDTA 2% glycerol, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2011 Sep 9

R_g^Guinier	4.2	nm
D_max	17.0	nm
Volume^Porod	68	nm³

SASDB63 – Human dystrophin central domain repeats 11 to 15

UniProt ID: P11532 (1461-1973) Dystrophin central domain repeats 11 to 15.

Dystrophin central domain repeats 11 to 15. experimental SAS data

Sample:	Dystrophin central domain repeats 11 to 15. monomer, 60 kDa Homo sapiens protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM EDTA 2% glycerol, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2011 Apr 11

R_g^Guinier	5.8	nm
D_max	23.0	nm
Volume^Porod	87	nm³

SASDB73 – Human dystrophin central domain repeats 4 to 9

UniProt ID: P11532 (718-1368) Dystrophin central domain repeats 4 to 9

Dystrophin central domain repeats 4 to 9 experimental SAS data

Sample:	Dystrophin central domain repeats 4 to 9 monomer, 76 kDa Homo sapiens protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM EDTA 2% glycerol, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2012 Sep 19

R_g^Guinier	7.7	nm
D_max	30.5	nm
Volume^Porod	123	nm³

SASDB83 – Human dystrophin central domain repeats 16 to 17

UniProt ID: P11532 (1984-2216) Dystrophin central domain repeats 16 to 17.

Dystrophin central domain repeats 16 to 17. experimental SAS data

Sample:	Dystrophin central domain repeats 16 to 17. monomer, 28 kDa Homo sapiens protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM EDTA 2% glycerol, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2012 Sep 19

R_g^Guinier	3.1	nm
D_max	13.0	nm
Volume^Porod	47	nm³

SASDB93 – Human dystrophin central domain repeats 16 to 19

UniProt ID: P11532 (1994-2420) Dystrophin central domain repeats 16 to 19.

Dystrophin central domain repeats 16 to 19. experimental SAS data

Sample:	Dystrophin central domain repeats 16 to 19. monomer, 50 kDa Homo sapiens protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM EDTA 2% glycerol 5% acetonitrile, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2013 Oct 4

R_g^Guinier	4.6	nm
D_max	20.0	nm
Volume^Porod	70	nm³

SASDBA3 – Human dystrophin central domain repeats 20 to 24

UniProt ID: P11532 (2469-3040) Dystrophin central domain repeats 20 to 24.

Dystrophin central domain repeats 20 to 24. experimental SAS data

Sample:	Dystrophin central domain repeats 20 to 24. monomer, 67 kDa Homo sapiens protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM EDTA 2% glycerol, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2011 Jul 10

R_g^Guinier	5.8	nm
D_max	22.5	nm
Volume^Porod	107	nm³

SASDBB3 – Human dystrophin central domain single repeat 23

UniProt ID: P11532 (2800-2939) Dystrophin central domain single repeat 23

Dystrophin central domain single repeat 23 experimental SAS data

Sample:	Dystrophin central domain single repeat 23 monomer, 17 kDa Homo sapiens protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM EDTA 2% glycerol, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2011 Oct 7

R_g^Guinier	2.2	nm
D_max	7.4	nm
Volume^Porod	20	nm³

SASDBG3 – Leucine-rich repeat transmembrane neuronal protein 2, cLRRTM2 (stability engineered construct)

UniProt ID: Q8BGA3 (30-380) Mouse Leucine-rich repeat transmembrane neuronal protein 2, cLRRTM2 (stability engineered construct)

Mouse Leucine-rich repeat transmembrane neuronal protein 2, cLRRTM2 (stability engineered construct) experimental SAS data

Sample:	Mouse Leucine-rich repeat transmembrane neuronal protein 2, cLRRTM2 (stability engineered construct) monomer, 40 kDa Mus musculus protein
Buffer:	20 mM Tris 150 mM NaCl 3% glycerol, pH: 7.4
Experiment:	SAXS data collected at ID14-3, ESRF on 2015 Sep 27

Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Biochemistry 55(6):914-26 (2016)
Paatero A, Rosti K, Shkumatov AV, Sele C, Brunello C, Kysenius K, Singha P, Jokinen V, Huttunen H, Kajander T

R_g^Guinier	3.3	nm
D_max	13.1	nm

SASDBH3 – Leucine-rich repeat transmembrane neuronal protein 2, LRRTM2 (fragment 30-380)

UniProt ID: Q8BGA3 (30-380) Mouse Leucine-rich repeat transmembrane neuronal protein 2, LRRTM2

Mouse Leucine-rich repeat transmembrane neuronal protein 2, LRRTM2 experimental SAS data

Sample:	Mouse Leucine-rich repeat transmembrane neuronal protein 2, LRRTM2 dimer, 80 kDa Mus musculus protein
Buffer:	20 mM Tris 150 mM NaCl 3% glycerol, pH: 7.4
Experiment:	SAXS data collected at ID14-3, ESRF on 2015 Jun 28

R_g^Guinier	4.2	nm
D_max	21.6	nm

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