SASBDB entries for UniProt ID:

SASDRA9 – Aromatic-L-amino-acid decarboxylase (AADC) - dopa methylester DME-bound holo form

UniProt ID: P20711 (None-None) Aromatic-L-amino-acid decarboxylase (M17V)

Aromatic-L-amino-acid decarboxylase (M17V) experimental SAS data
DAMMIN model
Sample: Aromatic-L-amino-acid decarboxylase (M17V) dimer, 108 kDa Homo sapiens protein
Buffer: 50 mM HEPES, pH: 7.4
Experiment: SAXS data collected at B21, Diamond Light Source on 2022 Feb 28
Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: implication in AADC deficiency Protein Science (2023)
Bisello G, Ribeiro R, Perduca M, Belviso B, Polverino de' Laureto P, Giorgetti A, Caliandro R, Bertoldi M
RgGuinier 3.0 nm
Dmax 14.5 nm
VolumePorod 154 nm3

SASDRB9 – Bruton's Tyrosine Kinase - full-length

UniProt ID: P35991 (1-659) Tyrosine-protein kinase BTK

Tyrosine-protein kinase BTK experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK monomer, 77 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 4.1 nm
Dmax 19.1 nm
VolumePorod 118 nm3

SASDRC9 – Bruton's Tyrosine Kinase - full-length with A384P, S386P, T387P, A388P and L390F mutations

UniProt ID: P35991 (1-659) Tyrosine-protein kinase BTK (A384P, S386P, T387P, A388P, L390F)

Tyrosine-protein kinase BTK (A384P, S386P, T387P, A388P, L390F) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (A384P, S386P, T387P, A388P, L390F) monomer, 77 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 3.9 nm
Dmax 15.2 nm
VolumePorod 107 nm3

SASDRD9 – Bruton's Tyrosine Kinase - SH3-SH2-kinase domain

UniProt ID: P35991 (214-659) Tyrosine-protein kinase BTK (SH3-SH2-kinase domains)

Tyrosine-protein kinase BTK (SH3-SH2-kinase domains) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (SH3-SH2-kinase domains) monomer, 52 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 2.4 nm
Dmax 7.5 nm
VolumePorod 68 nm3

SASDRE9 – Bruton's Tyrosine Kinase - SH3-SH2-kinase domain with A384P, S386P, T387P, A388P and L390F mutations

UniProt ID: P35991 (214-659) Tyrosine-protein kinase BTK (SH3-SH2-kinase domain A384P, S386P, T387P, A388P, L390F)

Tyrosine-protein kinase BTK (SH3-SH2-kinase domain A384P, S386P, T387P, A388P, L390F) experimental SAS data
DAMMIF model
Sample: Tyrosine-protein kinase BTK (SH3-SH2-kinase domain A384P, S386P, T387P, A388P, L390F) monomer, 53 kDa Mus musculus protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2% v/v glycerol, pH: 8
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Dec 9
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 12 (2024)
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
RgGuinier 2.5 nm
Dmax 7.8 nm
VolumePorod 71 nm3

SASDRG9 – Stromal cell-derived factor 1, CXCL12

UniProt ID: P48061 (22-89) Stromal cell-derived factor 1

Stromal cell-derived factor 1 experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Stromal cell-derived factor 1 monomer, 9 kDa Homo sapiens protein
Buffer: 20 mM Tris, 50 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2021 Nov 11
The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12. Nat Commun 15(1):1201 (2024)
Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G
RgGuinier 1.5 nm
Dmax 4.8 nm
VolumePorod 19 nm3

SASDRH9 – High mobility group protein B1, HMGB1

UniProt ID: P63159 (2-215) High mobility group protein B1 (D189E, E202D, E215D)

High mobility group protein B1 (D189E, E202D, E215D) experimental SAS data
High mobility group protein B1, HMGB1 Rg histogram
Sample: High mobility group protein B1 (D189E, E202D, E215D) monomer, 25 kDa Rattus norvegicus protein
Buffer: 20 mM Tris, 50 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2021 Nov 11
The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12. Nat Commun 15(1):1201 (2024)
Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G
RgGuinier 2.6 nm
Dmax 8.5 nm
VolumePorod 53 nm3

SASDRJ9 – High mobility group protein B1/Stromal cell-derived factor 1 complex (HMGB1-CXCL12)

UniProt ID: P48061 (22-89) Stromal cell-derived factor 1

UniProt ID: P63159 (2-215) High mobility group protein B1 (D189E, E202D, E215D)

Stromal cell-derived factor 1High mobility group protein B1 (D189E, E202D, E215D) experimental SAS data
Stromal cell-derived factor 1 High mobility group protein B1 (D189E, E202D, E215D) Kratky plot
Sample: Stromal cell-derived factor 1 monomer, 9 kDa Homo sapiens protein
High mobility group protein B1 (D189E, E202D, E215D) monomer, 25 kDa Rattus norvegicus protein
Buffer: 20 mM Tris, 50 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2021 Nov 11
The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12. Nat Commun 15(1):1201 (2024)
Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G
RgGuinier 2.9 nm
Dmax 10.5 nm
VolumePorod 72 nm3

SASDS22 – Sulfite reductase flavoprotein crosslinked octamer

UniProt ID: P38038 (1-599) Sulfite reductase [NADPH] flavoprotein alpha-component

Sulfite reductase [NADPH] flavoprotein alpha-component experimental SAS data
SASREF model
Sample: Sulfite reductase [NADPH] flavoprotein alpha-component octamer, 530 kDa Escherichia coli (strain … protein
Buffer: 50 mM potassium phosphate, 100 mM NaCl, 1 mM EDTA, pH: 7.8
Experiment: SANS data collected at EQ-SANS, Spallation Neutron Source on 2022 Jun 24
Domain crossover in the reductase subunit of NADPH-dependent assimilatory sulfite reductase. J Struct Biol 215(4):108028 (2023)
Walia N, Murray DT, Garg Y, He H, Weiss KL, Nagy G, Elizabeth Stroupe M
RgGuinier 8.4 nm
Dmax 23.0 nm
VolumePorod 767 nm3

SASDS32 – Reconstituted sulfite reductase crosslinked dodecamer with partially deuterated hemoprotein in 86% D2O

UniProt ID: P17846 (1-570) Sulfite reductase [NADPH] hemoprotein beta-component

UniProt ID: P38038 (1-599) Sulfite reductase [NADPH] flavoprotein alpha-component (E121C, C162T, C552S, N556C)

Sulfite reductase [NADPH] hemoprotein beta-componentSulfite reductase [NADPH] flavoprotein alpha-component (E121C, C162T, C552S, N556C) experimental SAS data
Sample: Sulfite reductase [NADPH] hemoprotein beta-component tetramer, 256 kDa Escherichia coli (strain … protein
Sulfite reductase [NADPH] flavoprotein alpha-component (E121C, C162T, C552S, N556C) octamer, 566 kDa Escherichia coli (strain … protein
Buffer: 50 mM potassium phosphate, 100 mM NaCl, 1 mM EDTA, pH: 7.8
Experiment: SANS data collected at EQ-SANS, Spallation Neutron Source on 2023 Apr 24
Domain crossover in the reductase subunit of NADPH-dependent assimilatory sulfite reductase. J Struct Biol 215(4):108028 (2023)
Walia N, Murray DT, Garg Y, He H, Weiss KL, Nagy G, Elizabeth Stroupe M
RgGuinier 7.5 nm
Dmax 22.6 nm
VolumePorod 823 nm3