SASBDB entries for UniProt ID:

SASDWK3 – Thomasclavelia ramosa immunoglobulin A protease middle domain with C-terminal domain #1

UniProt ID: Q9AES2 (329-876) IgA protease
IgA protease experimental SAS data
PHENIX model
Sample: IgA protease monomer, 63 kDa Thomasclavelia ramosa protein
Buffer: 25 mM HEPES, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2023 Jun 26
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proc Natl Acad Sci U S A 122(35):e2503549122 (2025)
Tran N, Frenette A, Holyoak T
RgGuinier 2.7 nm
Dmax 9.2 nm
VolumePorod 89 nm3

SASDWL3 – Thomasclavelia ramosa immunoglobulin A protease C-terminal domain #2

UniProt ID: Q9AES2 (880-1008) IgA protease
IgA protease experimental SAS data
ALPHAFOLD model
Sample: IgA protease monomer, 14 kDa Thomasclavelia ramosa protein
Buffer: 25 mM HEPES, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2023 Jun 26
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proc Natl Acad Sci U S A 122(35):e2503549122 (2025)
Tran N, Frenette A, Holyoak T
RgGuinier 2.5 nm
Dmax 9.6 nm
VolumePorod 12 nm3

SASDWM3 – Thomasclavelia ramosa immunoglobulin A protease N-terminal domain with middle (protease) domain

UniProt ID: Q9AES2 (31-807) IgA protease
IgA protease experimental SAS data
CORAL model
Sample: IgA protease monomer, 88 kDa Thomasclavelia ramosa protein
Buffer: 25 mM HEPES, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2023 Jun 26
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proc Natl Acad Sci U S A 122(35):e2503549122 (2025)
Tran N, Frenette A, Holyoak T
RgGuinier 3.3 nm
Dmax 10.8 nm
VolumePorod 108 nm3

SASDWN3 – Thomasclavelia ramosa immunoglobulin A protease C-terminal tail

UniProt ID: Q9AES2 (808-1170) IgA protease
IgA protease experimental SAS data
CORAL model
Sample: IgA protease monomer, 39 kDa Thomasclavelia ramosa protein
Buffer: 25 mM HEPES, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2023 Jun 26
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proc Natl Acad Sci U S A 122(35):e2503549122 (2025)
Tran N, Frenette A, Holyoak T
RgGuinier 5.3 nm
Dmax 21.5 nm
VolumePorod 52 nm3

SASDWP3 – Thomasclavelia ramosa immunoglobulin A protease middle (protease) domain with C-terminal tail

UniProt ID: Q9AES2 (329-1170) IgA protease
IgA protease experimental SAS data
CORAL model
Sample: IgA protease monomer, 95 kDa Thomasclavelia ramosa protein
Buffer: 25 mM HEPES, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2023 Jun 26
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proc Natl Acad Sci U S A 122(35):e2503549122 (2025)
Tran N, Frenette A, Holyoak T
RgGuinier 5.7 nm
Dmax 24.0 nm
VolumePorod 160 nm3

SASDWQ3 – Thomasclavelia ramosa full-length immunoglobulin A protease

UniProt ID: Q9AES2 (31-1195) IgA protease
IgA protease experimental SAS data
CORAL model
Sample: IgA protease monomer, 131 kDa Thomasclavelia ramosa protein
Buffer: 25 mM HEPES, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at ID7A1 BioSAXS / HP-Bio Beamline, Cornell High Energy Synchrotron Source (CHESS) on 2023 Jun 26
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proc Natl Acad Sci U S A 122(35):e2503549122 (2025)
Tran N, Frenette A, Holyoak T
RgGuinier 5.5 nm
Dmax 24.5 nm
VolumePorod 188 nm3

SASDW74 – Aromatic-L-amino-acid decarboxylase L353P bound to pyridoxal 5'-phosphate (PLP)

UniProt ID: P20711 (1-478) Aromatic-L-amino-acid decarboxylase (L353P)
Aromatic-L-amino-acid decarboxylase (L353P) experimental SAS data
DAMMIN model
Sample: Aromatic-L-amino-acid decarboxylase (L353P) dimer, 107 kDa Homo sapiens protein
Buffer: 50 mM HEPES, pH: 7.4
Experiment: SAXS data collected at B21, Diamond Light Source on 2021 Jul 7
The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis. FEBS J (2025)
Carmona-Carmona CA, Bisello G, Franchini R, Lunardi G, Galavotti R, Perduca M, Ribeiro RP, Belviso BD, Giorgetti A, Caliandro R, Lievens PM, Bertoldi M
RgGuinier 3.1 nm
Dmax 8.8 nm
VolumePorod 152 nm3

SASDW84 – Aromatic-L-amino-acid decarboxylase R347Q bound to pyridoxal 5'-phosphate (PLP)

UniProt ID: P20711 (1-478) Aromatic-L-amino-acid decarboxylase (R347Q)
Aromatic-L-amino-acid decarboxylase (R347Q) experimental SAS data
DAMMIN model
Sample: Aromatic-L-amino-acid decarboxylase (R347Q) dimer, 108 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 100 µM pyridoxal 5'-phosphate, pH: 7.4
Experiment: SAXS data collected at BM29, ESRF on 2021 Jul 7
The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis. FEBS J (2025)
Carmona-Carmona CA, Bisello G, Franchini R, Lunardi G, Galavotti R, Perduca M, Ribeiro RP, Belviso BD, Giorgetti A, Caliandro R, Lievens PM, Bertoldi M
RgGuinier 3.6 nm
Dmax 14.2 nm
VolumePorod 220 nm3

SASDW94 – Horse apoferritin from AF4-SAXS measurements

UniProt ID: P02791 (1-175) Ferritin light chain
Ferritin light chain experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Ferritin light chain 24-mer, 480 kDa Equus caballus protein
Buffer: phosphate buffered saline, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Jun 19
AF4-to-SAXS: expanded characterization of nanoparticles and proteins at the P12 BioSAXS beamline. J Synchrotron Radiat (2025)
Da Vela S, Bartels K, Franke D, Soloviov D, Gräwert T, Molodenskiy D, Kolb B, Wilhelmy C, Drexel R, Meier F, Haas H, Langguth P, Graewert MA
RgGuinier 5.4 nm
Dmax 13.3 nm
VolumePorod 632 nm3

SASDWA4 – Yeast alcohol dehydrogenase 1 from AF4-SAXS measurements

UniProt ID: P00330 (1-348) Alcohol dehydrogenase 1
Alcohol dehydrogenase 1 experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Alcohol dehydrogenase 1 tetramer, 147 kDa Saccharomyces cerevisiae (strain … protein
Buffer: phosphate buffered saline, 1% glycerol, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Apr 13
AF4-to-SAXS: expanded characterization of nanoparticles and proteins at the P12 BioSAXS beamline. J Synchrotron Radiat (2025)
Da Vela S, Bartels K, Franke D, Soloviov D, Gräwert T, Molodenskiy D, Kolb B, Wilhelmy C, Drexel R, Meier F, Haas H, Langguth P, Graewert MA
RgGuinier 3.4 nm
Dmax 9.5 nm
VolumePorod 197 nm3