Browse by MODEL: Hybrid

SASDSV7 – Gramicidin Synthetase 1 (GrsA) W239S mutant in the holo form in the presence of 4 molar excess of L-Tyrosine and ATP analog (AMPPCP)

Gramicidin S synthase 1 (W239S) experimental SAS data
Sample: Gramicidin S synthase 1 (W239S) monomer, 126 kDa Brevibacillus brevis protein
Buffer: 20 mM Tris pH 7.5, 100 mM NaCl, 10 mM MgCl2, 2% glycerol, pH: 7.5
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2023 Mar 14
Resting state of GrsA is a combination of two constitutively inactive isoforms that manifest long-range allosteric effects in presence of aminoacid and ATP
Raktim Roy
RgGuinier 4.0 nm
Dmax 14.3 nm
VolumePorod 175 nm3

SASDU89 – Apolipoprotein A-I monomer, C-terminally truncated

Apolipoprotein A-I experimental SAS data
COOT model
Sample: Apolipoprotein A-I monomer, 22 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, 0.1% sodium azide, pH: 7.4
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2021 Mar 20
The structure of the apolipoprotein A-I monomer provides insights into its oligomerisation and lipid-binding mechanisms Journal of Molecular Biology :169394 (2025)
Tou H, Rosenes Z, Khandokar Y, Zlatic C, Metcalfe R, Mok Y, Morton C, Gooley P, Griffin M
RgGuinier 2.3 nm
Dmax 7.9 nm
VolumePorod 27 nm3

SASDUC9 – Full-length apolipoprotein A-I in complex with antigen-binding fragment 55201

Apolipoprotein A-IAntigen-binding fragment 55201 experimental SAS data
COOT model
Sample: Apolipoprotein A-I monomer, 28 kDa Homo sapiens protein
Antigen-binding fragment 55201 monomer, 45 kDa Mus musculus protein
Buffer: 20 mM Tris, 150 mM NaCl, 0.1% sodium azide, pH: 7.4
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2021 Jun 19
The structure of the apolipoprotein A-I monomer provides insights into its oligomerisation and lipid-binding mechanisms Journal of Molecular Biology :169394 (2025)
Tou H, Rosenes Z, Khandokar Y, Zlatic C, Metcalfe R, Mok Y, Morton C, Gooley P, Griffin M
RgGuinier 4.6 nm
Dmax 17.5 nm
VolumePorod 99 nm3

SASDVC4 – Shwachman-Bodian-Diamond syndrome protein (SBDS) - wild type

Ribosome maturation protein SBDS experimental SAS data
MULTIFOXS model
Sample: Ribosome maturation protein SBDS monomer, 29 kDa Homo sapiens protein
Buffer: 50 mM Tris pH 8.0, 10% glycerol, 300 mM NaCl, 5 mM MgCl2., pH:
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Apr 6
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation ACS Omega (2025)
Mattiotti G, Nanna V, Giulini M, Alberga D, Mangiatordi G, Sánchez-Puig N, Saviano M, Tubiana L, Potestio R, Lattanzi G, Siliqi D
RgGuinier 3.0 nm
Dmax 11.4 nm
VolumePorod 50 nm3

SASDVD4 – Shwachman-Bodian-Diamond syndrome protein (SBDS) - R19Q mutant

Ribosome maturation protein SBDS (R19Q) experimental SAS data
MULTIFOXS model
Sample: Ribosome maturation protein SBDS (R19Q) monomer, 29 kDa Homo sapiens protein
Buffer: 50 mM Tris pH 8.0, 10% glycerol, 300 mM NaCl, 5 mM MgCl2., pH:
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Apr 6
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation ACS Omega (2025)
Mattiotti G, Nanna V, Giulini M, Alberga D, Mangiatordi G, Sánchez-Puig N, Saviano M, Tubiana L, Potestio R, Lattanzi G, Siliqi D
RgGuinier 2.9 nm
Dmax 12.2 nm
VolumePorod 46 nm3

SASDVE4 – Shwachman-Bodian-Diamond syndrome protein (SBDS) - I167T mutant

Ribosome maturation protein SBDS (I167T) experimental SAS data
MULTIFOXS model
Sample: Ribosome maturation protein SBDS (I167T) monomer, 29 kDa Homo sapiens protein
Buffer: 50 mM Tris pH 8.0, 10% glycerol, 300 mM NaCl, 5 mM MgCl2., pH:
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Apr 6
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation ACS Omega (2025)
Mattiotti G, Nanna V, Giulini M, Alberga D, Mangiatordi G, Sánchez-Puig N, Saviano M, Tubiana L, Potestio R, Lattanzi G, Siliqi D
RgGuinier 2.9 nm
Dmax 10.5 nm
VolumePorod 44 nm3

SASDVF4 – Shwachman-Bodian-Diamond syndrome protein (SBDS) - R175W mutant

Ribosome maturation protein SBDS (R175W) experimental SAS data
MULTIFOXS model
Sample: Ribosome maturation protein SBDS (R175W) monomer, 29 kDa Homo sapiens protein
Buffer: 50 mM Tris pH 8.0, 10% glycerol, 300 mM NaCl, 5 mM MgCl2., pH:
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Apr 6
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD Investigation ACS Omega (2025)
Mattiotti G, Nanna V, Giulini M, Alberga D, Mangiatordi G, Sánchez-Puig N, Saviano M, Tubiana L, Potestio R, Lattanzi G, Siliqi D
RgGuinier 3.1 nm
Dmax 11.6 nm
VolumePorod 48 nm3

SASDXW3 – Transthyretin tetramer

Transthyretin experimental SAS data
COOT model
Sample: Transthyretin tetramer, 55 kDa Homo sapiens protein
Buffer: 20 mM Tris, 50 mM NaCl, pH: 7
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2022 Sep 4
Differentiating the solution structures and stability of transthyretin tetramer complexed with tolcapone and tafamidis using SEC-SWAXS and NMR. J Appl Crystallogr 58(Pt 4):1373-1383 (2025)
Shih O, Feng YC, Agrawal S, Liao KF, Yeh YQ, Chang JW, Yu TY, Jeng US
RgGuinier 2.4 nm
Dmax 7.2 nm
VolumePorod 92 nm3

SASDXX3 – Transthyretin tetramer with over-saturated tolcapone

TransthyretinTolcapone experimental SAS data
COOT model
Sample: Transthyretin tetramer, 55 kDa Homo sapiens protein
Tolcapone dimer, 1 kDa
Buffer: 20 mM Tris, 50 mM NaCl, pH: 7
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2023 May 19
Differentiating the solution structures and stability of transthyretin tetramer complexed with tolcapone and tafamidis using SEC-SWAXS and NMR. J Appl Crystallogr 58(Pt 4):1373-1383 (2025)
Shih O, Feng YC, Agrawal S, Liao KF, Yeh YQ, Chang JW, Yu TY, Jeng US
RgGuinier 2.5 nm
Dmax 8.6 nm
VolumePorod 107 nm3

SASDXY3 – Transthyretin tetramer with over-saturated tafamidis

TransthyretinTafamidis experimental SAS data
COOT model
Sample: Transthyretin tetramer, 55 kDa Homo sapiens protein
Tafamidis dimer, 1 kDa
Buffer: 20 mM Tris, 50 mM NaCl, pH: 7
Experiment: SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2023 May 19
Differentiating the solution structures and stability of transthyretin tetramer complexed with tolcapone and tafamidis using SEC-SWAXS and NMR. J Appl Crystallogr 58(Pt 4):1373-1383 (2025)
Shih O, Feng YC, Agrawal S, Liao KF, Yeh YQ, Chang JW, Yu TY, Jeng US
RgGuinier 2.5 nm
Dmax 9.0 nm
VolumePorod 69 nm3