Browse by MACROMOLECULE type: protein

SASDZM5 – ACTN2-G111V using SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 13.0 nm
Dmax 55.5 nm

SASDZN5 – ACTN2-R93Q using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.6 nm
Dmax 37.0 nm

SASDZP5 – ACTN2-R93Q using SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 12.9 nm
Dmax 57.0 nm

SASDZQ5 – ACTN2-M92V using SEC-SAXS (dimer peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.5 nm
Dmax 36.1 nm

SASDZR5 – Alpha-actinin-2 (ACTN2) M92V variant, SEC-SAXS (aggregate peak)

Alpha-actinin-2 experimental SAS data
Alpha-actinin-2 Kratky plot
Sample: Alpha-actinin-2 dimer, 208 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 May 13
ACTN2 HCM-linked Missense Variants
Maya Noureddine
RgGuinier 11.6 nm
Dmax 49.0 nm

SASDZ46 – Engineered LysM-CHAP derivative of autolysin LytN (Fc-hel8-L1-3)

Fc-hel8-L1-3 experimental SAS data
Fc-hel8-L1-3 Kratky plot
Sample: Fc-hel8-L1-3 dimer, 109 kDa S.aureus protein
Buffer: 20 mM HEPES, 150 mM NaCl, pH 7.0, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2025 Apr 6
SEC-SAXS data of Fc-hel8-L1-3
Adriana Badarau
RgGuinier 6.4 nm
Dmax 30.0 nm

SASDXW5 – Replicase polyprotein 1ab-ORF1ab polyprotein (RdRp) protein complex from SARS CoV-2

Replicase polyprotein 1abReplicase polyprotein 1abORF1ab polyprotein experimental SAS data
DAMMIF model
Sample: Replicase polyprotein 1ab monomer, 9 kDa Severe acute respiratory … protein
Replicase polyprotein 1ab dimer, 44 kDa Severe acute respiratory … protein
ORF1ab polyprotein monomer, 106 kDa Human coronavirus OC43 protein
Buffer: 50 mM HEPES, 200 mM NaCl, pH: 8
Experiment: SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2025 Mar 24
RdRp
RgGuinier 5.2 nm
Dmax 10.1 nm
VolumePorod 213 nm3

SASDXJ6 – CD2-associated protein (CD2AP)

CD2-associated protein experimental SAS data
CD2-associated protein Kratky plot
Sample: CD2-associated protein hexamer, 429 kDa Homo sapiens protein
Buffer: 10 mM potassium phosphate, pH: 7.6
Experiment: SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2025 May 16
CD2AP’s Structure and Oligomerization are compromised by the K301M mutation: implications for Nephrotic syndrome
Anil Kumar Pasupulati et .al
RgGuinier 10.7 nm
Dmax 35.5 nm

SASDXK6 – CD2-associated protein (CD2AP) K301M point mutant

CD2-associated protein experimental SAS data
CD2-associated protein Kratky plot
Sample: CD2-associated protein trimer, 214 kDa Homo sapiens protein
Buffer: 10 mM potassium phosphate, pH: 7.6
Experiment: SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2025 May 18
CD2AP’s Structure and Oligomerization are compromised by the K301M mutation: implications for Nephrotic syndrome
Anil Kumar Pasupulati et .al
RgGuinier 9.6 nm
Dmax 33.9 nm

SASDXW6 – Angiotensin-converting enzyme 2

Angiotensin Converting Enzyme2 experimental SAS data
Angiotensin Converting Enzyme2 Kratky plot
Sample: Angiotensin Converting Enzyme2 dimer, 185 kDa Homo sapiens protein
Buffer: 50mM Tris, 200mM NaCl, pH: 8
Experiment: SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2021 Jul 29
ACE 2 protein
Raja Tripathi
RgGuinier 5.4 nm
Dmax 27.5 nm
VolumePorod 569 nm3