Solution structures of glycosaminoglycan-bound CXCL8 complexes determined by small-angle X-ray scattering (SAXS).

White MA, Mahler BP, Joseph PRB, Nagarajan B, Wang X, Desai UR, Rajarathnam K
Biochem J 483(10):1861-1876 (2026 Oct 7)

PMID: 42619214 doi: 10.1042/BCJ20260348

Submitted to SASBDB: 2026 Jul 20 Published in SASBDB: 2026 Sep 7

SASD2N2 – Heparin 8-mer Sample: Heparin 8-mer monomer, 2 kDa Buffer: 20 mM sodium succinate, 100 mM NaCl, 5 mM MgCl2, pH: 5.5 Experiment: SAXS data collected at Rigaku BioSAXS-1000, Sealy Center For Structural Biology, UTMB-G on 2018 Jan 9 RgGuinier 1.0 nm Dmax 3.3 nm

SASD2P2 – Chondroitin 8-mer Sample: Chondroitin sulfate 8-mer monomer, 2 kDa NA Buffer: Phosphate buffer, pH: 7 Experiment: SAXS data collected at Rigaku BioSAXS-1000, Sealy Center For Structural Biology, UTMB-G on 2016 Mar 21 RgGuinier 1.0 nm Dmax 3.7 nm

SASD2Q2 – Interleukin-8 (CXCL8) Sample: INTERLEUKIN 8 dimer, 16 kDa Homo sapiens protein Buffer: Phosphate buffer, pH: 7 Experiment: SAXS data collected at Rigaku BioSAXS-1000, Sealy Center For Structural Biology, UTMB-G on 2016 Mar 21 RgGuinier 1.6 nm Dmax 5.2 nm

SASD2R2 – Interleukin-8-Chondroitin sulphate (CXCL8:CS08) Sample: Chondroitin sulfate 8-mer monomer, 2 kDa NA INTERLEUKIN 8 dimer, 16 kDa Homo sapiens protein Buffer: 50 mM phosphate, pH: 7 Experiment: SAXS data collected at Rigaku BioSAXS-1000, Sealy Center For Structural Biology, UTMB-G on 2016 Mar 21 RgGuinier 1.7 nm Dmax 6.6 nm

SASD2S2 – Interleukin-8-Heparin sulfate (CXCL8:Heparin) Sample: INTERLEUKIN 8 dimer, 16 kDa Homo sapiens protein Heparin 8-mer monomer, 2 kDa Buffer: 20 mM sodium succinate, 100 mM NaCl, 5mM MgCl2, pH: 5.5 Experiment: SAXS data collected at Rigaku BioSAXS-1000, Sealy Center For Structural Biology, UTMB-G on 2017 Dec 17 RgGuinier 2.6 nm Dmax 11.0 nm