Small Angle Scattering Biological Data Bank SASBDB

SASBDB entries for UniProt ID:

SASDSF8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 0.55 mg/mL

UniProt ID: Q8IZF6 (26-240) Adhesion G-protein coupled receptor G4

Adhesion G-protein coupled receptor G4 experimental SAS data

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces. J Biol Chem :105356 (2023)
Kieslich B, Weiße RH, Brendler J, Ricken A, Schöneberg T, Sträter N

R_g^Guinier	2.8	nm
D_max	8.0	nm
Volume^Porod	65	nm³

SASDSG8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 1.07 mg/mL

UniProt ID: Q8IZF6 (26-240) Adhesion G-protein coupled receptor G4

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	2.9	nm
D_max	9.0	nm
Volume^Porod	70	nm³

SASDSH8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 1.88 mg/mL

UniProt ID: Q8IZF6 (26-240) Adhesion G-protein coupled receptor G4

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	3.0	nm
D_max	9.7	nm
Volume^Porod	74	nm³

SASDSJ8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 4.37 mg/mL

UniProt ID: Q8IZF6 (26-240) Adhesion G-protein coupled receptor G4

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	3.0	nm
D_max	9.9	nm
Volume^Porod	76	nm³

SASDSK8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 6.38 mg/mL

UniProt ID: Q8IZF6 (26-240) Adhesion G-protein coupled receptor G4

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	3.0	nm
D_max	9.9	nm
Volume^Porod	77	nm³

SASDSL8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 7.51 mg/mL

UniProt ID: Q8IZF6 (26-240) Adhesion G-protein coupled receptor G4

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	2.9	nm
D_max	9.6	nm
Volume^Porod	77	nm³

SASDSM8 – Adhesion G protein-coupled receptor G4 PTX-like domain at 9.15 mg/mL

UniProt ID: Q8IZF6 (26-240) Adhesion G-protein coupled receptor G4

Sample:	Adhesion G-protein coupled receptor G4 dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl, 150 mM NaCl, 5% (w/v) glycerol, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2019 Jun 21

R_g^Guinier	2.9	nm
D_max	10.8	nm
Volume^Porod	78	nm³

SASDSU8 – Threonine aldolase 1 tetramer at neutral pH

UniProt ID: Q6XPS7 (41-400) L-threonine aldolase

L-threonine aldolase experimental SAS data

Sample:	L-threonine aldolase tetramer, 165 kDa Mus musculus protein
Buffer:	20 mM Tris, 150 mM NaCl, 1 mM EDTA, 1 mM DTT, pH: 7.8
Experiment:	SAXS data collected at BM29, ESRF on 2023 Feb 14

One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse. Nat Commun 15(1):3199 (2024)
Malatesta M, Fornasier E, Di Salvo ML, Tramonti A, Zangelmi E, Peracchi A, Secchi A, Polverini E, Giachin G, Battistutta R, Contestabile R, Percudani R

R_g^Guinier	3.7	nm
D_max	10.6	nm
Volume^Porod	209	nm³

SASDSV8 – Tyrosine-protein kinase Src (c-Src WT)

UniProt ID: P12931 (84-536) Proto-oncogene tyrosine-protein kinase Src

Proto-oncogene tyrosine-protein kinase Src experimental SAS data

Sample:	Proto-oncogene tyrosine-protein kinase Src monomer, 52 kDa Homo sapiens protein
Buffer:	20 mM Tris pH 8.0, 150 mM NaCl, 1% glycerol and 1 mM DTT, pH: 8
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 May 8

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function Nature Communications 14(1) (2023)
Cuesta-Hernández H, Contreras J, Soriano-Maldonado P, Sánchez-Wandelmer J, Yeung W, Martín-Hurtado A, Muñoz I, Kannan N, Llimargas M, Muñoz J, Plaza-Menacho I

R_g^Guinier	2.6	nm
D_max	8.9	nm
Volume^Porod	67	nm³

SASDSW8 – Apo form of vaccinia virus polymerase holoenzyme E9-A20-D4

UniProt ID: P20509 (2-1006) DNA polymerase

UniProt ID: P20995 (1-426) DNA polymerase processivity factor component OPG148

UniProt ID: P20536 (1-218) Uracil-DNA glycosylase

DNA polymeraseDNA polymerase processivity factor component OPG148Uracil-DNA glycosylase experimental SAS data

DNA polymerase DNA polymerase processivity factor component OPG148 Uracil-DNA glycosylase Kratky plot

Sample:	DNA polymerase monomer, 117 kDa Vaccinia virus (strain … protein DNA polymerase processivity factor component OPG148 monomer, 49 kDa Vaccinia virus (strain … protein Uracil-DNA glycosylase monomer, 27 kDa Vaccinia virus (strain … protein
Buffer:	200 mM NaCl, 20 mM Tris-HCl and 1 mM TCEP, pH: 8.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Jan 25

Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus. PLoS Pathog 20(5):e1011652 (2024)
Burmeister WP, Boutin L, Balestra AC, Gröger H, Ballandras-Colas A, Hutin S, Kraft C, Grimm C, Böttcher B, Fischer U, Tarbouriech N, Iseni F

R_g^Guinier	5.0	nm
D_max	18.0	nm
Volume^Porod	350	nm³

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