Browse by DISSEMINATION: Published

SASDV97 – The 60bp dsDNA oligo GAGE6_2

GAGE6_2 experimental SAS data
GAGE6_2 Kratky plot
Sample: GAGE6_2 dimer, 37 kDa Homo sapiens DNA
Buffer: 150 mM KCl, 20 mM HEPES, 5% glycerol, 5 mM MgCl2, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2023 Nov 28
Probing the statistics of sequence-dependent DNA conformations in solution using SAXS. Acta Crystallogr D Struct Biol 82(Pt 2):79-99 (2026)
Koning HJ, Pullakhandam A, Whitten AE, Bond CS, Peyrard M
RgGuinier 5.2 nm
Dmax 18.4 nm
VolumePorod 72 nm3

SASDVA7 – The 60bp dsDNA oligo GAGE6_3

GAGE6_3 experimental SAS data
GAGE6_3 Kratky plot
Sample: GAGE6_3 dimer, 37 kDa Homo sapiens DNA
Buffer: 150 mM KCl, 20 mM HEPES, 5% glycerol, 5 mM MgCl2, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2023 Nov 28
Probing the statistics of sequence-dependent DNA conformations in solution using SAXS. Acta Crystallogr D Struct Biol 82(Pt 2):79-99 (2026)
Koning HJ, Pullakhandam A, Whitten AE, Bond CS, Peyrard M
RgGuinier 5.0 nm
Dmax 21.4 nm
VolumePorod 80 nm3

SASDXH7 – GAGE6 60bp dsDNA oligonucleotide

GAGE6 60bp dsDNA oligo experimental SAS data
DAMMIN model
Sample: GAGE6 60bp dsDNA oligo monomer, 37 kDa Homo sapiens DNA
Buffer: 150 mM KCl, 20 mM HEPES, 5% glycerol, 5 mM MgCl2, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at SAXS/WAXS, Australian Synchrotron on 2023 Mar 14
Probing the statistics of sequence-dependent DNA conformations in solution using SAXS. Acta Crystallogr D Struct Biol 82(Pt 2):79-99 (2026)
Koning HJ, Pullakhandam A, Whitten AE, Bond CS, Peyrard M
RgGuinier 4.8 nm
Dmax 19.5 nm
VolumePorod 101 nm3

SASDVG4 – Human CDAN1-interacting nuclease 1 (frames 717 - 723)

CDAN1-interacting nuclease 1 experimental SAS data
ALPHAFOLD model
Sample: CDAN1-interacting nuclease 1 dimer, 67 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
Stojaspal M, Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 2.8 nm
Dmax 9.9 nm
VolumePorod 85 nm3

SASDVH4 – Human Codanin1 C-terminal domain (frames 779 - 791)

Codanin-1 experimental SAS data
ALPHAFOLD model
Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
Stojaspal M, Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 2.5 nm
Dmax 9.3 nm
VolumePorod 51 nm3

SASDVJ4 – Complex of CDAN1-interacting nuclease 1 and Codanin1 C-terminal domain (frames 712 - 720)

Codanin-1CDAN1-interacting nuclease 1 experimental SAS data
ALPHAFOLD model
Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein
CDAN1-interacting nuclease 1 monomer, 33 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
Stojaspal M, Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 3.0 nm
Dmax 10.6 nm
VolumePorod 102 nm3

SASDV39 – Human CDAN1-interacting nuclease 1 (frames 692 - 701)

CDAN1-interacting nuclease 1 experimental SAS data
ALPHAFOLD model
Sample: CDAN1-interacting nuclease 1 monomer, 33 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
Stojaspal M, Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 2.8 nm
Dmax 8.9 nm
VolumePorod 104 nm3

SASDV49 – Human Codanin1 C-terminal domain (frames 842 - 851)

Codanin-1 experimental SAS data
ALPHAFOLD model
Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein
Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease. FEBS J (2026)
Stojaspal M, Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
RgGuinier 2.4 nm
Dmax 7.4 nm
VolumePorod 46 nm3

SASDXB2 – Phosphoglycerate kinase

Phosphoglycerate kinase experimental SAS data
ALPHAFOLD model
Sample: Phosphoglycerate kinase monomer, 45 kDa Nakaseomyces glabratus protein
Buffer: 50 mM sodium phosphate, 500 mM NaCl, 500 mM imidazole, 1 mM phenylmethylsulfonyl fluoride (PMSF), pH: 8.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2025 Feb 13
Integrative Structural Characterization of Candida glabrata Phosphoglycerate Kinase by Small-Angle X-ray Scattering and AlphaFold: Implications for Therapeutic Targeting in Candidiasis ACS Omega (2026)
Cuéllar-Cruz M, Maqueda Cabrera E, Siliqi D, Moreno A
RgGuinier 2.9 nm
Dmax 10.3 nm
VolumePorod 79 nm3

SASDXL8 – A nuclear mRNA-binding protein bound to GT-repeat DNA Oligo: TDP-43 (TAR DNA-binding protein 43)

TAR DNA-binding protein 43 experimental SAS data
TAR DNA-binding protein 43 Kratky plot
Sample: TAR DNA-binding protein 43 monomer, 63 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 100 mM KCl, 2 mM TCEP, pH: 7.6
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Nov 30
From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach. Nat Commun (2026)
Feng Y, Joshi V, Pankivskyi S, Clément MJ, Rengifo-Gonzalez JC, Thureau A, Pastré D, Bouhss A
RgGuinier 4.0 nm
Dmax 16.5 nm
VolumePorod 135 nm3