Browse by ORGANISM: Homo sapiens (Human)

SASDD75 – 'TG'-interacting factor homeodomain in solution (Homeobox protein TGIF1)

Homeobox protein TGIF1 experimental SAS data
'TG'-interacting factor homeodomain in solution (Homeobox protein TGIF1) Rg histogram
Sample: Homeobox protein TGIF1 dimer, 23 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.4
Experiment: SAXS data collected at EMBL P12, PETRA III on 2016 Oct 18
'TG' interacting factor
Ewelina Guca
RgGuinier 2.7 nm
Dmax 9.2 nm
VolumePorod 42 nm3

SASDG44 – Adenovirus Ad3 fibre knob in complex with the EC2-EC3 fragment of desmoglein 2

Human adenovirus serotype 3 fibre knobHuman desmoglein 2 extracellular domain 2 and 3 experimental SAS data
OTHER model
Sample: Human adenovirus serotype 3 fibre knob trimer, 69 kDa Human adenovirus serotype … protein
Human desmoglein 2 extracellular domain 2 and 3 dimer, 55 kDa Homo sapiens protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 3 mM CaCl2, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2017 Jan 26
Intermediate-resolution crystal structure of the human adenovirus B serotype 3 fibre knob in complex with the EC2-EC3 fragment of desmoglein 2. Acta Crystallogr F Struct Biol Commun 75(Pt 12):750-757 (2019)
Vassal-Stermann E, Hutin S, Fender P, Burmeister WP
RgGuinier 3.4 nm
Dmax 11.2 nm
VolumePorod 188 nm3

SASDKS3 – The dimeric ectodomain of the alkali-sensing insulin receptor–related receptor (ectoIRR) at pH7

Insulin receptor-related protein experimental SAS data
CORAL model
Sample: Insulin receptor-related protein dimer, 201 kDa Homo sapiens protein
Buffer: 150 mM NaCl, 20 mM Tris, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2016 Oct 22
The dimeric ectodomain of the alkali-sensing insulin receptor-related receptor (ectoIRR) has a droplike shape. J Biol Chem 294(47):17790-17798 (2019)
Shtykova EV, Petoukhov MV, Mozhaev AA, Deyev IE, Dadinova LA, Loshkarev NA, Goryashchenko AS, Bocharov EV, Jeffries CM, Svergun DI, Batishchev OV, Petrenko AG
RgGuinier 5.4 nm
Dmax 19.5 nm
VolumePorod 444 nm3

SASDKT3 – The dimeric ectodomain of the alkali-sensing insulin receptor–related receptor (ectoIRR) at pH9

Insulin receptor-related protein experimental SAS data
CORAL model
Sample: Insulin receptor-related protein dimer, 201 kDa Homo sapiens protein
Buffer: 150 mM NaCl, 20 mM Tris, pH: 9
Experiment: SAXS data collected at EMBL P12, PETRA III on 2016 Oct 22
The dimeric ectodomain of the alkali-sensing insulin receptor-related receptor (ectoIRR) has a droplike shape. J Biol Chem 294(47):17790-17798 (2019)
Shtykova EV, Petoukhov MV, Mozhaev AA, Deyev IE, Dadinova LA, Loshkarev NA, Goryashchenko AS, Bocharov EV, Jeffries CM, Svergun DI, Batishchev OV, Petrenko AG
RgGuinier 5.3 nm
Dmax 19.0 nm
VolumePorod 430 nm3

SASDE32 – Mothers against decapentaplegic homolog 5 - Smad5 MH1

Mothers against decapentaplegic homolog 5 experimental SAS data
Mothers against decapentaplegic homolog 5 Kratky plot
Sample: Mothers against decapentaplegic homolog 5, 15 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2018 Feb 14
Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes (2019)
Ruiz L, Kaczmarska Z, Gomes T, Aragón E, Torner C, Freier R, Bagiński B, Martin-Malpartida P, de Martin Garrido N, Márquez J, Cordeiro T, Pluta R, Macias M
RgGuinier 1.9 nm
Dmax 6.6 nm
VolumePorod 32 nm3

SASDE42 – Mothers against decapentaplegic homolog 8_9 - Smad8_9 MH1

Mothers against decapentaplegic homolog 8_9 experimental SAS data
Mothers against decapentaplegic homolog 8_9 Kratky plot
Sample: Mothers against decapentaplegic homolog 8_9, 15 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.2
Experiment: SAXS data collected at BM29, ESRF on 2018 Mar 1
Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes (2019)
Ruiz L, Kaczmarska Z, Gomes T, Aragón E, Torner C, Freier R, Bagiński B, Martin-Malpartida P, de Martin Garrido N, Márquez J, Cordeiro T, Pluta R, Macias M
RgGuinier 1.9 nm
Dmax 6.5 nm
VolumePorod 34 nm3

SASDGV4 – Model of the RH1-LZ1 domains of C-Jun-amino-terminal kinase-interacting protein 3 (JIP3)

C-Jun-amino-terminal kinase-interacting protein 3 experimental SAS data
OTHER model
Sample: C-Jun-amino-terminal kinase-interacting protein 3 dimer, 40 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, 0.5 mM TCEP, pH: 7.1
Experiment: SAXS data collected at SWING, SOLEIL on 2018 Sep 22
Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif. Sci Rep 9(1):16036 (2019)
Vilela F, Velours C, Chenon M, Aumont-Nicaise M, Campanacci V, Thureau A, Pylypenko O, Andreani J, Llinas P, Ménétrey J
RgGuinier 6.3 nm
Dmax 23.1 nm
VolumePorod 140 nm3

SASDGW4 – Model of the LZ1 domain of C-Jun-amino-terminal kinase-interacting protein 3 (JIP3)

C-Jun-amino-terminal kinase-interacting protein 3 experimental SAS data
OTHER model
Sample: C-Jun-amino-terminal kinase-interacting protein 3 dimer, 40 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, 0.5 mM TCEP, pH: 7.1
Experiment: SAXS data collected at SWING, SOLEIL on 2018 Sep 22
Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif. Sci Rep 9(1):16036 (2019)
Vilela F, Velours C, Chenon M, Aumont-Nicaise M, Campanacci V, Thureau A, Pylypenko O, Andreani J, Llinas P, Ménétrey J
RgGuinier 5.0 nm
Dmax 19.8 nm
VolumePorod 84 nm3

SASDFT4 – Conformation of the R11-15 human dystrophin fragment (SANS)

Dystrophin (R11-15 human dystrophin fragment) experimental SAS data
CUSTOM IN-HOUSE model
Sample: Dystrophin (R11-15 human dystrophin fragment) monomer, 60 kDa Homo sapiens protein
Buffer: 20 mM Tris-d11, 150 mM NaCl, 0.1 mM EDTA-d16, in 100% v/v D2O, pH: 7.1
Experiment: SANS data collected at D22, Institut Laue-Langevin (ILL) on 2016 Nov 1
How the central domain of dystrophin acts to bridge F-actin to sarcolemmal lipids. J Struct Biol :107411 (2019)
Mias-Lucquin D, Dos Santos Morais R, Chéron A, Lagarrigue M, Winder SJ, Chenuel T, Pérez J, Appavou MS, Martel A, Alviset G, Le Rumeur E, Combet S, Hubert JF, Delalande O
RgGuinier 6.2 nm
Dmax 27.4 nm
VolumePorod 146 nm3

SASDFU4 – Conformation of R11-15 human dystrophin fragment in interaction with zwitterionic phospholipid bicelles (SANS)

Dystrophin (R11-15 human dystrophin fragment) experimental SAS data
DAMMIF model
Sample: Dystrophin (R11-15 human dystrophin fragment) monomer, 60 kDa Homo sapiens protein
Buffer: 20 mM Tris-d11, 150 mM NaCl, 0.1 mM EDTA-d16, in 100% v/v D2O, pH: 7.1
Experiment: SANS data collected at D22, Institut Laue-Langevin (ILL) on 2016 Nov 1
How the central domain of dystrophin acts to bridge F-actin to sarcolemmal lipids. J Struct Biol :107411 (2019)
Mias-Lucquin D, Dos Santos Morais R, Chéron A, Lagarrigue M, Winder SJ, Chenuel T, Pérez J, Appavou MS, Martel A, Alviset G, Le Rumeur E, Combet S, Hubert JF, Delalande O
RgGuinier 6.2 nm
Dmax 28.1 nm
VolumePorod 144 nm3