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22 hits found for Tully

SASDTV5 – Human full-length Annexin A11 (apo form)

Annexin A11 experimental SAS data
Annexin A11 Kratky plot
Sample: Annexin A11 monomer, 54 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM KCl, 5 mM EDTA, 1 mM DTT, pH: 8.5
Experiment: SAXS data collected at BM29, ESRF on 2023 Jul 21
The structural properties of full-length annexin A11 Frontiers in Molecular Biosciences 11 (2024)
...Tully M, Foldes T, Kelly G, Tartaglia G, Pastore A
RgGuinier 3.8 nm
Dmax 15.9 nm
VolumePorod 84 nm3

SASDTW5 – Human full-length Annexin A11 (holo form, with calcium)

Annexin A11 experimental SAS data
Annexin A11 Kratky plot
Sample: Annexin A11 monomer, 54 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM KCl, 500 µM CaCl2, 1 mM DTT, pH: 8.5
Experiment: SAXS data collected at BM29, ESRF on 2023 Jul 21
The structural properties of full-length annexin A11 Frontiers in Molecular Biosciences 11 (2024)
...Tully M, Foldes T, Kelly G, Tartaglia G, Pastore A
RgGuinier 3.8 nm
Dmax 17.1 nm
VolumePorod 83 nm3

SASDRC6 – Dual specificity mitogen-activated protein kinase kinase 6 (MKK6GRA) bound to mitogen-activated protein kinase 14 (p38α) with ADP-AlF4

Mitogen-activated protein kinase 14Dual specificity mitogen-activated protein kinase kinase 6Adenosine 5'-Diphosphate Tetrafluoroaluminate experimental SAS data
Mitogen-activated protein kinase 14 Dual specificity mitogen-activated protein kinase kinase 6 Adenosine 5'-Diphosphate Tetrafluoroaluminate Kratky plot
Sample: Mitogen-activated protein kinase 14 monomer, 40 kDa Homo sapiens protein
Dual specificity mitogen-activated protein kinase kinase 6 monomer, 42 kDa synthetic construct protein
Adenosine 5'-Diphosphate Tetrafluoroaluminate monomer, 1 kDa
Buffer: 50 mM HEPES, 200 mM NaCl, 10 mM MgCl2, 5 % glycerol, 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 May 15
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation Science 381(6663):1217-1225 (2023)
...Tully M, Vadas O, Gervasio F, Pellegrini E, Bowler M
RgGuinier 3.2 nm
Dmax 12.1 nm
VolumePorod 113 nm3

SASDRD6 – Dual specificity mitogen-activated protein kinase kinase 6 (MKK6GRA) bound to mitogen-activated protein kinase 14 (p38α) with AMP-PCP

Mitogen-activated protein kinase 14Dual specificity mitogen-activated protein kinase kinase 65′‐adenylyl methylenediphosphonate experimental SAS data
Mitogen-activated protein kinase 14 Dual specificity mitogen-activated protein kinase kinase 6 5′‐adenylyl methylenediphosphonate Kratky plot
Sample: Mitogen-activated protein kinase 14 monomer, 40 kDa Homo sapiens protein
Dual specificity mitogen-activated protein kinase kinase 6 monomer, 42 kDa synthetic construct protein
5′‐adenylyl methylenediphosphonate monomer, 1 kDa
Buffer: 50 mM HEPES, 200 mM NaCl, 10 mM MgCl2, 5 % glycerol, 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 May 15
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation Science 381(6663):1217-1225 (2023)
...Tully M, Vadas O, Gervasio F, Pellegrini E, Bowler M
RgGuinier 4.2 nm
Dmax 14.0 nm
VolumePorod 116 nm3

SASDY37 – MADS transcription factor SEPALLATA 3 (SEP3)

Developmental protein SEPALLATA 3 experimental SAS data
Developmental protein SEPALLATA 3 Kratky plot
Sample: Developmental protein SEPALLATA 3 dimer, 24 kDa Arabidopsis thaliana protein
Buffer: 50 mM Tris, 300 mM NaCl, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2020 Feb 23
The phytoplasma effector, phyllogen, structurally mimics host plant MADS transcription factors. J Biol Chem 302(10):113449 (2026)
...Tully MD, Hugouvieux V, Zubieta C
RgGuinier 4.0 nm
Dmax 15.4 nm
VolumePorod 530 nm3

SASDY47 – Phytoplasmal effector causing phyllody 1 (Phyl1)

Phytoplasmal effector causing phyllody 1 experimental SAS data
Phytoplasmal effector causing phyllody 1 Kratky plot
Sample: Phytoplasmal effector causing phyllody 1 monomer, 11 kDa Onion yellows phytoplasma … protein
Buffer: 50 mM Tris, 300 mM NaCl, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2020 Feb 23
The phytoplasma effector, phyllogen, structurally mimics host plant MADS transcription factors. J Biol Chem 302(10):113449 (2026)
...Tully MD, Hugouvieux V, Zubieta C
RgGuinier 2.2 nm
Dmax 6.6 nm
VolumePorod 51 nm3

SASDY57 – MADS transcription factor SEPALLATA 3 (SEP3) bound to Phytoplasmal effector causing phyllody 1

Developmental protein SEPALLATA 3Phytoplasmal effector causing phyllody 1 experimental SAS data
Developmental protein SEPALLATA 3 Phytoplasmal effector causing phyllody 1 Kratky plot
Sample: Developmental protein SEPALLATA 3 dimer, 24 kDa Arabidopsis thaliana protein
Phytoplasmal effector causing phyllody 1 monomer, 11 kDa Onion yellows phytoplasma … protein
Buffer: 50 mM Tris, 300 mM NaCl, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2020 Feb 23
The phytoplasma effector, phyllogen, structurally mimics host plant MADS transcription factors. J Biol Chem 302(10):113449 (2026)
...Tully MD, Hugouvieux V, Zubieta C
RgGuinier 3.8 nm
Dmax 13.6 nm
VolumePorod 200 nm3

SASDU77 – Human IgG1 F(ab') 5C05

Human IgG1 F(ab') 5C05 experimental SAS data
Human IgG1 F(ab') 5C05 Kratky plot
Sample: Human IgG1 F(ab') 5C05 monomer, 46 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 May 9
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 2.5 nm
Dmax 7.7 nm
VolumePorod 59 nm3

SASDU87 – Deglycosylated Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 5C05 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 5C05 experimental SAS data
MOLECULAR DYNAMICS FRAME model
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 5C05 monomer, 46 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 May 18
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 3.5 nm
Dmax 14.0 nm
VolumePorod 95 nm3

SASDU97 – Human IgG1 F(ab') 6C11

Human IgG1 F(ab') 6C11 experimental SAS data
Human IgG1 F(ab') 6C11 Kratky plot
Sample: Human IgG1 F(ab') 6C11 monomer, 24 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 May 9
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 2.5 nm
Dmax 7.6 nm
VolumePorod 56 nm3

SASDUA7 – Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 6C11 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 6C11 experimental SAS data
Low affinity immunoglobulin gamma Fc region receptor II-b Human IgG1 F(ab') 6C11 Kratky plot
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 6C11 monomer, 24 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 May 9
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 3.4 nm
Dmax 12.0 nm
VolumePorod 110 nm3

SASDUB7 – Human IgG1 F(ab') 6G11

Human IgG1 F(ab') 6G11 experimental SAS data
Human IgG1 F(ab') 6G11 Kratky plot
Sample: Human IgG1 F(ab') 6G11 monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 5
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 2.6 nm
Dmax 8.5 nm
VolumePorod 60 nm3

SASDUC7 – Deglycosylated Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 6G11 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 6G11 experimental SAS data
MOLECULAR DYNAMICS FRAME model
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 6G11 monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2017 Apr 9
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 3.5 nm
Dmax 13.5 nm
VolumePorod 97 nm3

SASDUD7 – Human IgG1 F(ab') 7C07

Human IgG1 F(ab') 7C07 experimental SAS data
Human IgG1 F(ab') 7C07 Kratky plot
Sample: Human IgG1 F(ab') 7C07 monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 5
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 2.6 nm
Dmax 8.2 nm
VolumePorod 59 nm3

SASDUE7 – Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 7C07 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 7C07 experimental SAS data
Low affinity immunoglobulin gamma Fc region receptor II-b Human IgG1 F(ab') 7C07 Kratky plot
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 7C07 monomer, 25 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2014 Dec 5
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 3.6 nm
Dmax 13.5 nm
VolumePorod 110 nm3

SASDUF7 – Deglycosylated Fc gamma receptor IIb (CD32b) extracellular domain in complex with human IgG1 6G08 F(ab')

Low affinity immunoglobulin gamma Fc region receptor II-bHuman IgG1 F(ab') 6G08 experimental SAS data
MOLECULAR DYNAMICS FRAME model
Sample: Low affinity immunoglobulin gamma Fc region receptor II-b monomer, 20 kDa Homo sapiens protein
Human IgG1 F(ab') 6G08 monomer, 24 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 Dec 14
Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling. Immunity (2026)
...Tully MD, Teige I, Tornberg UC, Tynan CJ, Pendower A, Kim J, Tennenhouse A, Fleishman SJ, Essex JW, Tews I, Cragg MS
RgGuinier 3.3 nm
Dmax 12.0 nm
VolumePorod 96 nm3

SASDNB8 – Mature full length human prion protein

Major prion protein experimental SAS data
Mature full length human prion protein Rg histogram
Sample: Major prion protein monomer, 23 kDa Homo sapiens protein
Buffer: 10 mM HEPES 100 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13
A tetracationic porphyrin with dual anti-prion activity. iScience 26(9):107480 (2023)
...Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R
RgGuinier 2.8 nm
Dmax 10.2 nm

SASDNC8 – Mature full length human prion protein in the presence of zinc-tetracationic porphyrin [Zn(II)-BnPyP]

Major prion protein experimental SAS data
Mature full length human prion protein in the presence of zinc-tetracationic porphyrin [Zn(II)-BnPyP] Rg histogram
Sample: Major prion protein monomer, 23 kDa Homo sapiens protein
Buffer: 10 mM HEPES 100 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13
A tetracationic porphyrin with dual anti-prion activity. iScience 26(9):107480 (2023)
...Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R
RgGuinier 3.1 nm
Dmax 11.3 nm

SASDND8 – Mature full length human prion protein in the presence of a cationic Fe(III) porphyrin [Fe(III)-TMPyP]

Major prion protein experimental SAS data
Mature full length human prion protein in the presence of a cationic Fe(III) porphyrin [Fe(III)-TMPyP] Rg histogram
Sample: Major prion protein monomer, 23 kDa Homo sapiens protein
Buffer: 10 mM HEPES 100 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2020 Dec 13
A tetracationic porphyrin with dual anti-prion activity. iScience 26(9):107480 (2023)
...Tully MD, Cecatiello V, Ciossani G, Pasqualato S, Van Anken E, Salmona M, Castilla J, Requena JR, Banfi S, Musco G, Chiesa R
RgGuinier 2.8 nm
Dmax 10.3 nm

SASDEV6 – KRAB-associated protein 1 (KAP1); TRIM28; full length protein

Transcription intermediary factor 1-beta, TIF1b, KAP1, TRIM28 experimental SAS data
GASBOR model
Sample: Transcription intermediary factor 1-beta, TIF1b, KAP1, TRIM28 dimer, 183 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 500 mM NaCl, 10 % Glycerol, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2017 Jul 6
KAP1 is an antiparallel dimer with a functional asymmetry. Life Sci Alliance 2(4) (2019)
...Tully MD, Grudinin S, Trono D, Fierz B, Dal Peraro M
RgGuinier 9.0 nm
Dmax 38.0 nm
VolumePorod 710 nm3

SASDER7 – KRAB-associated protein 1 (KAP1); TRIM28, amino acids 23-812

Transcription intermediary factor 1-beta, TIF1b, KAP1, TRIM28; amino acids 23-812 experimental SAS data
Transcription intermediary factor 1-beta, TIF1b, KAP1, TRIM28; amino acids 23-812 Kratky plot
Sample: Transcription intermediary factor 1-beta, TIF1b, KAP1, TRIM28; amino acids 23-812 dimer, 175 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 500 mM NaCl, 10 % Glycerol, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2017 Jul 6
KAP1 is an antiparallel dimer with a functional asymmetry. Life Sci Alliance 2(4) (2019)
...Tully MD, Grudinin S, Trono D, Fierz B, Dal Peraro M
RgGuinier 8.9 nm
Dmax 38.0 nm
VolumePorod 853 nm3

SASDEW6 – KRAB-associated protein 1, (KAP1); TRIM28; 23-418 RBCC domain

Transcription intermediary factor 1-beta, TIF1b, KAP1, TRIM28, Fragment 23-418, RBCC domain experimental SAS data
GASBOR model
Sample: Transcription intermediary factor 1-beta, TIF1b, KAP1, TRIM28, Fragment 23-418, RBCC domain dimer, 92 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 500 mM NaCl, 10 % Glycerol, 2 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2017 Jul 6
KAP1 is an antiparallel dimer with a functional asymmetry. Life Sci Alliance 2(4) (2019)
...Tully MD, Grudinin S, Trono D, Fierz B, Dal Peraro M
RgGuinier 8.3 nm
Dmax 37.0 nm
VolumePorod 381 nm3