Small Angle Scattering Biological Data Bank SASBDB

SASBDB entries for UniProt ID:

SASDXV2 – RAR/RXR heterodimer : BMS493 : NCoR NID : IR0 element

UniProt ID: P11416 (82-421) Retinoic acid receptor alpha

UniProt ID: None (None-None) BMS493 (RAR inverse agonist ligand)

UniProt ID: P19793 (126-462) Retinoid X receptor alpha

UniProt ID: None (None-None) Inverted Repeat binding site with zero-base-pair spacing

UniProt ID: Q60974 (2059-2325) Nuclear receptor corepressor 1

Retinoic acid receptor alphaBMS493 (RAR inverse agonist ligand)Retinoid X receptor alphaInverted Repeat binding site with zero-base-pair spacingNuclear receptor corepressor 1 experimental SAS data

Sample:	Retinoic acid receptor alpha monomer, 39 kDa Mus musculus protein BMS493 (RAR inverse agonist ligand) monomer, 0 kDa Retinoid X receptor alpha monomer, 38 kDa Homo sapiens protein Inverted Repeat binding site with zero-base-pair spacing monomer, 11 kDa DNA Nuclear receptor corepressor 1 monomer, 29 kDa Mus musculus protein
Buffer:	20 mM Tris HCl, 75 mM NaCl, 75 mM KCl, 2 mM CHAPS, 4 mM MgCl₂, 12 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2022 Apr 20

New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators. Nucleic Acids Res 53(18) (2025)
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernadó P, le Maire A

R_g^Guinier	5.5	nm
D_max	22.9	nm
Volume^Porod	257	nm³

SASDX83 – T. brucei Canonical Nucleosome Core Particle

UniProt ID: Q57YA3 (2-134) Histone H2A

UniProt ID: Q389T1 (2-112) Histone H2B

UniProt ID: Q4GYX7 (2-133) Histone H3, putative

UniProt ID: Q57Z31 (2-100) Histone H4

UniProt ID: None (None-None) Widom 601 145 bp DNA - strand 1

UniProt ID: None (None-None) Widom 601 145 bp DNA - strand 2

Histone H2AHistone H2BHistone H3, putativeHistone H4Widom 601 145 bp DNA - strand 1Widom 601 145 bp DNA - strand 2 experimental SAS data

Histone H2A Histone H2B Histone H3, putative Histone H4 Widom 601 145 bp DNA - strand 1 Widom 601 145 bp DNA - strand 2 Kratky plot

Sample:	Histone H2A, 28 kDa Trypanosoma brucei brucei … protein Histone H2B, 25 kDa Trypanosoma brucei brucei … protein Histone H3, putative, 29 kDa Trypanosoma brucei brucei … protein Histone H4, 22 kDa Trypanosoma brucei brucei … protein Widom 601 145 bp DNA - strand 1, 45 kDa DNA Widom 601 145 bp DNA - strand 2, 45 kDa DNA
Buffer:	20 mM HEPES, 150 mM NaCl, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Oct 10

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin

R_g^Guinier	4.3	nm
D_max	11.8	nm
Volume^Porod	435	nm³

SASDX93 – T. brucei H3.V+H4.V Nucleosome Core Particle

UniProt ID: Q57YA3 (2-134) Histone H2A

UniProt ID: Q389T1 (2-112) Histone H2B

UniProt ID: None (None-None) Widom 601 145 bp DNA - strand 1

UniProt ID: None (None-None) Widom 601 145 bp DNA - strand 2

UniProt ID: Q387X7 (2-139) Histone H3 variant

UniProt ID: Q587H6 (2-100) Histone H4

Histone H2AHistone H2BWidom 601 145 bp DNA - strand 1Widom 601 145 bp DNA - strand 2Histone H3 variantHistone H4 experimental SAS data

Histone H2A Histone H2B Widom 601 145 bp DNA - strand 1 Widom 601 145 bp DNA - strand 2 Histone H3 variant Histone H4 Kratky plot

Sample:	Histone H2A, 28 kDa Trypanosoma brucei brucei … protein Histone H2B, 25 kDa Trypanosoma brucei brucei … protein Widom 601 145 bp DNA - strand 1, 45 kDa DNA Widom 601 145 bp DNA - strand 2, 45 kDa DNA Histone H3 variant, 32 kDa Trypanosoma brucei brucei … protein Histone H4, 22 kDa Trypanosoma brucei brucei … protein
Buffer:	20 mM HEPES, 150 mM NaCl, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Oct 10

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin

R_g^Guinier	4.5	nm
D_max	13.1	nm
Volume^Porod	483	nm³

SASDXA3 – T. brucei H3.V-only Nucleosome Core Particle

UniProt ID: Q57YA3 (2-134) Histone H2A

UniProt ID: Q389T1 (2-112) Histone H2B

UniProt ID: Q57Z31 (2-100) Histone H4

UniProt ID: None (None-None) Widom 601 145 bp DNA - strand 1

UniProt ID: None (None-None) Widom 601 145 bp DNA - strand 2

UniProt ID: Q387X7 (2-139) Histone H3 variant

Histone H2AHistone H2BHistone H4Widom 601 145 bp DNA - strand 1Widom 601 145 bp DNA - strand 2Histone H3 variant experimental SAS data

Histone H2A Histone H2B Histone H4 Widom 601 145 bp DNA - strand 1 Widom 601 145 bp DNA - strand 2 Histone H3 variant Kratky plot

Sample:	Histone H2A, 28 kDa Trypanosoma brucei brucei … protein Histone H2B, 25 kDa Trypanosoma brucei brucei … protein Histone H4, 22 kDa Trypanosoma brucei brucei … protein Widom 601 145 bp DNA - strand 1, 45 kDa DNA Widom 601 145 bp DNA - strand 2, 45 kDa DNA Histone H3 variant, 32 kDa Trypanosoma brucei brucei … protein
Buffer:	20 mM HEPES, 150 mM NaCl, 1 mM DTT, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Oct 10

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin
Gauri Deak

R_g^Guinier	4.4	nm
D_max	13.2	nm
Volume^Porod	481	nm³

SASDXF6 – RTX cytotoxin pro-MbxA without acylation (pro-MbxA)

UniProt ID: Q93GI2 (None-None) RTX cytotoxin pro-MbxA without acylation

RTX cytotoxin pro-MbxA without acylation experimental SAS data

Sample:	RTX cytotoxin pro-MbxA without acylation monomer, 100 kDa Moraxella bovis protein
Buffer:	50 mM Tris, 100 mM NaCl, 10mM CaCl2, pH: 7.8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2022 May 9

Acylation of the RTX toxin MbxA stimulates host membrane disruption through a specific interaction with cholesterol Biochimica et Biophysica Acta (BBA) - Biomembranes :184487 (2025)
Chacko F, Ganz S, Pfitzer-Bilsing A, Hänsch S, Westhoff P, Weidtkamp-Peters S, Smits S, Exterkate M, Schmitt L

R_g^Guinier	3.8	nm
D_max	13.4	nm
Volume^Porod	154	nm³

SASDXG3 – CP12 protein from the marine diatom Thalassiosira pseudonana

UniProt ID: B8BQS1 (None-None) CP12 domain-containing protein

CP12 domain-containing protein experimental SAS data

Sample:	CP12 domain-containing protein dimer, 34 kDa Thalassiosira pseudonana protein
Buffer:	30 mM Tris, 50 mM NaCl, 2 mM EDTA, 1 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2019 Feb 23

A new type of flexible CP12 protein in the marine diatom Thalassiosira pseudonana Cell Communication and Signaling 19(1) (2021)
Shao H, Huang W, Avilan L, Receveur-Bréchot V, Puppo C, Puppo R, Lebrun R, Gontero B, Launay H

R_g^Guinier	3.8	nm
D_max	13.5	nm

SASDXJ3 – Human major vault protein

UniProt ID: Q14764 (1-893) Major vault protein

Major vault protein experimental SAS data

Sample:	Major vault protein, 7747 kDa Homo sapiens protein
Buffer:	25 mM HEPES, 150 mM NaCl, 1 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2022 Jun 8

Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations
Jana Aupič

R_g^Guinier	16.3	nm
D_max	65.0	nm
Volume^Porod	16650	nm³

SASDXK3 – Alkaline serine protease (36 kDa peptidase core domain, StmPr1)

UniProt ID: Q93IQ4 (151-509) Alkaline serine protease

Alkaline serine protease experimental SAS data

Sample:	Alkaline serine protease monomer, 36 kDa Stenotrophomonas maltophilia protein
Buffer:	20 mM Tris, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2023 Jun 10

Unveiling the structure, function and dynamics of StmPr1 in Stenotrophomonas maltophilia virulence. Sci Rep 15(1):20193 (2025)
Sommer M, Negm A, Outzen L, Windhorst S, Gabdulkhakov A, Weber W, Betzel C

R_g^Guinier	1.9	nm
D_max	5.5	nm
Volume^Porod	44	nm³

SASDXL3 – Alkaline serine protease (47 kDa peptidase core and C-terminal domains, StmPr1)

UniProt ID: Q93IQ4 (151-617) Alkaline serine protease (Δ1-150)

Alkaline serine protease (Δ1-150) experimental SAS data

Alkaline serine protease (Δ1-150) Kratky plot

Sample:	Alkaline serine protease (Δ1-150) monomer, 47 kDa Stenotrophomonas maltophilia protein
Buffer:	20 mM Tris, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Nov 25

R_g^Guinier	2.9	nm
D_max	10.0	nm
Volume^Porod	112	nm³

SASDXU3 – Farnesoid X Receptor Protein

UniProt ID: Q96RI1-1 (110-466) Isoform 3 of Bile acid receptor

Isoform 3 of Bile acid receptor experimental SAS data

Sample:	Isoform 3 of Bile acid receptor monomer, 41 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM NaCl, 5 % glycerol, 1 mM DTT, 20 µM CDCA, pH: 7.4
Experiment:	SAXS data collected at Rigaku BioSAXS-2000, Pennsylvania State University on 2024 May 9

DNA induces non-canonical dimerization of the farnesoid X receptor. Nucleic Acids Res 54(4) (2026)
Khan SH, Yennawar N, Okafor CD

R_g^Guinier	3.5	nm
D_max	11.6	nm
Volume^Porod	75	nm³

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