Small Angle Scattering Biological Data Bank SASBDB

Browse by ORGANISM: Homo sapiens (Human)

SASDCQ6 – Rap guanine nucleotide exchange factor 3 (isoform3) - apo form

Rap guanine nucleotide exchange factor 3 experimental SAS data

Sample:	Rap guanine nucleotide exchange factor 3 monomer, 100 kDa Homo sapiens protein
Buffer:	1mM EDTA, 10mM DTT, 500mM NaCl, and 10mM Tris, pH: 9
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, Sealy Center For Structural Biology, UTMB-G on 2012 Sep 7

Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology. Cells 9(1) (2019)
White MA, Tsalkova T, Mei FC, Cheng X

R_g^Guinier	3.4	nm
D_max	11.0	nm
Volume^Porod	180	nm³

SASDCR6 – Rap guanine nucleotide exchange factor 3 (isoform3) - binary form with cAMP

Rap guanine nucleotide exchange factor 3 (dimer) experimental SAS data

Sample:	Rap guanine nucleotide exchange factor 3 (dimer) dimer, 200 kDa Homo sapiens protein
Buffer:	1mM EDTA, 10mM DTT, 500mM NaCl, 1mM cAMP, and 10mM Tris, pH: 9
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, Sealy Center For Structural Biology, UTMB-G on 2012 Jan 30

R_g^Guinier	5.3	nm
D_max	15.7	nm
Volume^Porod	415	nm³

SASDCS6 – Rap guanine nucleotide exchange factor 3 (isoform3) bound to RAS related protein 1b - with cAMP

Rap guanine nucleotide exchange factor 3RAS related protein 1b experimental SAS data

Sample:	Rap guanine nucleotide exchange factor 3 monomer, 100 kDa Homo sapiens protein RAS related protein 1b monomer, 18 kDa Mus musculus protein
Buffer:	1mM EDTA, 10mM DTT, 500mM NaCl, 1mM cAMP, and 10mM Tris, pH: 9
Experiment:	SAXS data collected at Rigaku BioSAXS-1000, Sealy Center For Structural Biology, UTMB-G on 2013 Apr 1

R_g^Guinier	4.1	nm
D_max	14.2	nm
Volume^Porod	207	nm³

SASDF45 – Leukocidin/Integrin alpha-M complex (LukGH-huCD11b-I) in the presence of a neutralizing antibody Fab fragment

Leukocidin GLeukocidin HLukGH neutralizing antibodyIntegrin alpha-M experimental SAS data

Sample:	Leukocidin G monomer, 36 kDa Staphylococcus aureus protein Leukocidin H monomer, 38 kDa Staphylococcus aureus protein LukGH neutralizing antibody monomer, 47 kDa Homo sapiens protein Integrin alpha-M monomer, 22 kDa Homo sapiens protein
Buffer:	20 mM Hepes, 300 mM NaCl, 1 mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2017 Sep 17

Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity. Proc Natl Acad Sci U S A (2019)
Trstenjak N, Milić D, Graewert MA, Rouha H, Svergun D, Djinović-Carugo K, Nagy E, Badarau A

R_g^Guinier	5.0	nm
D_max	18.0	nm
Volume^Porod	178	nm³

SASDF55 – Leukocidin (LukGH) from Staphylococcus aureus in complex with a neutralizing antibody

Leukocidin GLeukocidin HLukGH neutralizing antibody experimental SAS data

Sample:	Leukocidin G monomer, 36 kDa Staphylococcus aureus protein Leukocidin H monomer, 38 kDa Staphylococcus aureus protein LukGH neutralizing antibody monomer, 47 kDa Homo sapiens protein
Buffer:	20 mM Hepes, 300 mM NaCl, 1 mM MgCl2, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2017 Sep 17

R_g^Guinier	4.7	nm
D_max	16.0	nm
Volume^Porod	152	nm³

SASDEN8 – Intracellular region of the human Cyclin and CBS domain divalent metal cation transport mediator-4 in complex with Phosphatase of Regenerating Liver-1 and MgATP

CNNM4_BAT-cNMP-CtailProtein tyrosine phosphatase type IVA 1 experimental SAS data

Sample:	CNNM4_BAT-cNMP-Ctail dimer, 96 kDa Homo sapiens protein Protein tyrosine phosphatase type IVA 1 dimer, 40 kDa Mus musculus protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Sep 17

Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4. Int J Mol Sci 20(24) (2019)
Giménez-Mascarell P, Oyenarte I, González-Recio I, Fernández-Rodríguez C, Corral-Rodríguez MÁ, Campos-Zarraga I, Simón J, Kostantin E, Hardy S, Díaz Quintana A, Zubillaga Lizeaga M, Merino N, Diercks T, Blanco FJ, Díaz Moreno I, Martínez-Chantar ML, Tremblay ML, Müller D, Siliqi D, Martínez-Cruz LA

R_g^Guinier	4.4	nm
D_max	18.3	nm
Volume^Porod	216	nm³

SASDEP8 – Intracellular region of the human Cyclin and CBS domain divalent metal cation transport mediator-4 in complex with Phosphatase of Regenerating Liver-1

Sample:	CNNM4_BAT-cNMP-Ctail dimer, 96 kDa Homo sapiens protein Protein tyrosine phosphatase type IVA 1 dimer, 40 kDa Mus musculus protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Aug 2

R_g^Guinier	4.7	nm
D_max	18.5	nm
Volume^Porod	226	nm³

SASDEQ8 – Intracellular region of the human Cyclin and CBS domain divalent metal cation transport mediator-4

CNNM4_BAT-cNMP-Ctail experimental SAS data

Sample:	CNNM4_BAT-cNMP-Ctail dimer, 96 kDa Homo sapiens protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Aug 2

R_g^Guinier	4.0	nm
D_max	16.6	nm
Volume^Porod	156	nm³

SASDER8 – Cyclic nucleotide homology domain of the human Cyclin and CBS domain divalent metal cation transport mediator-4

Sample:	CNNM4_cNMP dimer, 42 kDa Homo sapiens protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Feb 7

R_g^Guinier	2.6	nm
D_max	9.7	nm
Volume^Porod	102	nm³

SASDES8 – Intracellular region of the human Cyclin and CBS domain divalent metal cation transport mediator-4 in complex with MgATP

Sample:	CNNM4_BAT-cNMP-Ctail dimer, 96 kDa Homo sapiens protein
Buffer:	HEPES buffer pH 7.4, 200 mM NaCl , 1mM DTT, pH: 7.4
Experiment:	SAXS data collected at B21, Diamond Light Source on 2018 Sep 17

R_g^Guinier	3.9	nm
D_max	14.3	nm
Volume^Porod	149	nm³

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