Small Angle Scattering Biological Data Bank SASBDB


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38 hits found for Receptor Binding Domain

SASDL62 – ...domain of adenylate cyclase toxin CyaA - construct RTX-1 (amino acids 1132-1294 and 1562-1681 of CyaA)

hybrid RTX-1 construct (amino acids 1132-1294 and 1562-1681 of CyaA) experimental SAS data

Sample:	hybrid RTX-1 construct (amino acids 1132-1294 and 1562-1681 of CyaA) monomer, 30 kDa Bordetella pertussis protein
Buffer:	10 mM Tris HCl, 150 mM NaCl, 10 mM CaCl₂, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2016 Dec 1

...domain is dispensable for complement receptor 3 binding and cell-invasive activity of the adenylate cyclase toxin. J Biol Chem :100833 (2021)
Espinosa-Vinals CA, Masin J, Holubova J, Stanek O, Jurnecka D, Osicka R, Sebo P, Bumba L

R_g^Guinier	2.4	nm
D_max	8.2	nm
Volume^Porod	41	nm³

SASDL72 – ...domain of adenylate cyclase toxin CyaA - construct RTX-2 (amino acids 1132-1303 and 1562-1681 of CyaA)

hybrid RTX-2 construct (amino acids 1132-1303 and 1562-1681 of CyaA) experimental SAS data

Sample:	hybrid RTX-2 construct (amino acids 1132-1303 and 1562-1681 of CyaA) monomer, 31 kDa Bordetella pertussis protein
Buffer:	10 mM Tris HCl, 150 mM NaCl, 10 mM CaCl₂, pH: 8
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2016 Dec 1

R_g^Guinier	2.3	nm
D_max	8.0	nm
Volume^Porod	37	nm³

SASDF44 – RXR/RAR Heterodimer : N-CoRNID Complex (1:1)

Nuclear receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID)Retinoid-X receptor alpha (RXR-alpha) Ligand Binding Domain (LBD)Retinoic acid receptor alpha (RAR-alpha) Ligand binding domain (LDB) experimental SAS data

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein ...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2014 Jul 23

...Receptor Heterodimer and Its Corepressor Regulates Gene Expression. Structure (2019)
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernadó P

R_g^Guinier	4.8	nm
D_max	19.4	nm
Volume^Porod	167	nm³

SASDF54 – RXRΔH12/RAR Heterodimer : N-CoRNID Complex (1:1)

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein ...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RXR-alpha) Δ helix12 monomer, 24 kDa Mus musculus protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2014 Jul 23

R_g^Guinier	4.2	nm
D_max	15.7	nm
Volume^Porod	183	nm³

SASDF64 – RXR/RAR Heterodimer : N-CoRNID Complex (1:1) with RAR inverse agonist (BMS493)

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein ...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2014 Jul 23

R_g^Guinier	4.8	nm
D_max	19.5	nm
Volume^Porod	178	nm³

SASDF74 – RXR/RARI396E Heterodimer : N-CoRNID Complex (1:1)

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein ...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RAR-alpha) Ligand binding domain (LDB) mutant I396E monomer, 28 kDa Homo sapiens protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2015 Mar 9

R_g^Guinier	5.3	nm
D_max	22.4	nm
Volume^Porod	171	nm³

SASDF84 – RXR/RAR Heterodimer : N-CoRNID Complex (1:1) with RAR agonist (Am580)

Sample:	...receptor CoRepressor 1; Nuclear Receptor Interaction Domain (NID) monomer, 29 kDa Mus musculus protein ...receptor alpha (RXR-alpha) Ligand Binding Domain (LBD) monomer, 26 kDa Mus musculus protein ...receptor alpha (RAR-alpha) Ligand binding domain (LDB) monomer, 28 kDa Homo sapiens protein
Buffer:	50 mM Tris-HCl, 150 mM NaCl, 2 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2014 Jul 23

R_g^Guinier	4.2	nm
D_max	17.2	nm
Volume^Porod	131	nm³

SASDJG4 – ...receptor binding domain (RBD)

Spike glycoprotein (ACE2 receptor binding domain) experimental SAS data

Sample:	...receptor binding domain) monomer, 29 kDa Severe acute respiratory … protein
Buffer:	25 mM Tris 100 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2020 May 1

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2 Nature Communications 11(1) (2020)
Custódio T, Das H, Sheward D, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer M, Gruzinov A, Jeffries C, Graewert M, Svergun D, Dobrev N, Remans K, Seeger M, McInerney G, Murrell B, Hällberg B, ...

R_g^Guinier	3.0	nm
D_max	13.1	nm
Volume^Porod	64	nm³

SASDJH4 – ...receptor binding domain (RBD) bound to the synthetic nanobody Sybody 23 (Sy23)

Synthetic nanobody Sybody 23Spike glycoprotein (ACE2 receptor binding domain) experimental SAS data

Sample:	Synthetic nanobody Sybody 23 monomer, 16 kDa synthetic construct protein ...receptor binding domain) monomer, 29 kDa Severe acute respiratory … protein
Buffer:	25 mM Tris 100 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2020 May 10

R_g^Guinier	3.5	nm
D_max	15.1	nm
Volume^Porod	87	nm³

SASDMU4 – ...receptor RXR-alpha ligand binding domain (LBD)

Retinoic acid receptor RXR-alpha experimental SAS data

Sample:	...receptor RXR-alpha dimer, 51 kDa Homo sapiens protein
Buffer:	20 mM Tris, 100 mM NaCl, 100 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2010 Oct 7

...Domain of Retinoid X Receptor α in the Context of the Full-Length Protein Biochemistry 55(12):1741-1748 (2016)
Belorusova A, Osz J, Petoukhov M, Peluso-Iltis C, Kieffer B, Svergun D, Rochel N

R_g^Guinier	2.5	nm
D_max	8.3	nm
Volume^Porod	60	nm³

SASDMW4 – ...receptor RXR-alpha N-terminal and DNA binding domains (DBD) in complex with Ramp2 DNA

Ramp2 DNARetinoic acid receptor RXR-alpha experimental SAS data

Sample:	Ramp2 DNA monomer, 11 kDa DNA ...receptor RXR-alpha dimer, 44 kDa Homo sapiens protein
Buffer:	20 mM Tris, 50 mM NaCl, 50 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2009 Jul 17

R_g^Guinier	4.3	nm
D_max	14.3	nm
Volume^Porod	89	nm³

SASDMX4 – ...receptor RXR-alpha DNA binding (DBD) and ligand binding (LBD) domains in complex with Ramp2 DNA

Sample:	Ramp2 DNA monomer, 11 kDa DNA ...receptor RXR-alpha dimer, 74 kDa Homo sapiens protein
Buffer:	20 mM Tris, 50 mM NaCl, 50 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2010 Oct 7

R_g^Guinier	3.6	nm
D_max	12.2	nm

SASDMY4 – ...receptor RXR-alpha DNA binding domain (DBD) in complex with Ramp2

Sample:	Ramp2 DNA monomer, 11 kDa DNA ...receptor RXR-alpha dimer, 20 kDa Homo sapiens protein
Buffer:	20 mM Tris, 50 mM NaCl, 50 mM KCl, 5% glycerol, 2 mM Chaps, and 5 mM DTT, pH: 7.5
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2010 Oct 7

R_g^Guinier	1.9	nm
D_max	5.8	nm

SASDXX6 – ...Receptor binding domain

Receptor Binding DomainAngiotensin converting Enzyme 2 experimental SAS data

Receptor Binding Domain Angiotensin converting Enzyme 2 Kratky plot

Sample:	Receptor Binding Domain monomer, 25 kDa Severe acute respiratory … protein Angiotensin converting Enzyme 2 monomer, 92 kDa Homo sapiens protein
Buffer:	50mM Tris, 200mM NaCl, pH: 8
Experiment:	SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2021 Jul 29

ACE2 RBD Complex
Raja Tripathi

R_g^Guinier	6.7	nm
D_max	21.4	nm
Volume^Porod	783	nm³

SASDXZ6 – Receptor Binding Domain of SARS CoV-2

Receptor Binding Domain of SARS CoV-2 experimental SAS data

Receptor Binding Domain of SARS CoV-2 Kratky plot

Sample:	Receptor Binding Domain of SARS CoV-2 monomer, 25 kDa protein
Buffer:	50mM Tris, 200mM NaCl, pH: 8
Experiment:	SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2021 Jul 29

Receptor Binding Domain of SARS CoV-2
Raja Tripathi

R_g^Guinier	2.9	nm
D_max	6.1	nm
Volume^Porod	52	nm³

SASDC97 – ...Receptor 1 (DHp + CA + RD domains)

Ethylene receptor 1 dimerization histidine phosphotransfer + catalytic ATP-binding + receiver domains experimental SAS data

Ethylene receptor 1 dimerization histidine phosphotransfer + catalytic ATP-binding + receiver domains Kratky plot

Sample:	...receptor 1 dimerization histidine phosphotransfer + catalytic ATP-binding + receiver domains dimer, 88 kDa Arabidopsis thaliana protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM DTT 5 mM ADP, pH: 8.8
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2010 Oct 11

...domain of the plant ethylene receptor 1 (ETR1). J Biol Chem 290(5):2644-58 (2015)
Mayerhofer H, Panneerselvam S, Kaljunen H, Tuukkanen A, Mertens HD, Mueller-Dieckmann J

R_g^Guinier	4.0	nm
D_max	13.9	nm
Volume^Porod	144	nm³

SASDCA7 – ...Receptor 1 (DHp + CA domains)

Ethylene receptor 1 dimerization histidine phosphotransfer + catalytic ATP-binding domains experimental SAS data

Ethylene receptor 1 dimerization histidine phosphotransfer + catalytic ATP-binding domains Kratky plot

Sample:	...receptor 1 dimerization histidine phosphotransfer + catalytic ATP-binding domains dimer, 55 kDa Arabidopsis thaliana protein
Buffer:	20 mM Tris 150 mM NaCl 1 mM DTT 5 mM ADP, pH: 8.8
Experiment:	SAXS data collected at EMBL X33, DORIS III, DESY on 2010 Oct 11

...domain of the plant ethylene receptor 1 (ETR1). J Biol Chem 290(5):2644-58 (2015)
Mayerhofer H, Panneerselvam S, Kaljunen H, Tuukkanen A, Mertens HD, Mueller-Dieckmann J

R_g^Guinier	2.7	nm
D_max	8.7	nm
Volume^Porod	74	nm³

SASDWC7 – ...receptor alpha ligand binding domain (LBD) at pH 7.5

Estrogen receptor alpha experimental SAS data

Sample:	...receptor alpha dimer, 55 kDa Homo sapiens protein
Buffer:	20 mM Tris-HCl pH 7.5, 150 mM NaCl, 5% glycerol, 2 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at BioSAXS, Australian Synchrotron on 2024 Nov 9

...binding domain conformation. Nat Commun 16(1):10363 (2025)
McDougal DP, Pederick JL, Novick SJ, Jovcevski B, Warrender AK, Pascal BD, Griffin PR, Bruning JB

R_g^Guinier	2.4	nm
D_max	7.4	nm
Volume^Porod	74	nm³

SASDWD7 – ...receptor alpha ligand binding domain (LBD) at pH 7.5

Sample:	...receptor alpha dimer, 57 kDa Melanotaenia fluviatilis protein
Buffer:	20 mM Tris-HCl pH 7.5, 150 mM NaCl, 5% glycerol, 2 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at BioSAXS, Australian Synchrotron on 2024 Nov 9

...binding domain conformation. Nat Commun 16(1):10363 (2025)
McDougal DP, Pederick JL, Novick SJ, Jovcevski B, Warrender AK, Pascal BD, Griffin PR, Bruning JB

R_g^Guinier	2.5	nm
D_max	9.2	nm
Volume^Porod	72	nm³

SASDYG7 – ...Receptor binding domain, along with Umifenovir compound

Angiotensin-converting enzyme 2Spike glycoprotein experimental SAS data

Angiotensin-converting enzyme 2 Spike glycoprotein Kratky plot

Sample:	Angiotensin-converting enzyme 2 hexamer, 555 kDa Homo sapiens protein Spike glycoprotein hexamer, 150 kDa Severe acute respiratory … protein
Buffer:	50mM Tris, 150mM NaCl, pH: 8
Experiment:	SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2021 Oct 21

ACE 2 RBD
Raja Tripathi

R_g^Guinier	4.4	nm
D_max	11.4	nm

SASDMU7 – ...receptor-binding domain of SARS-CoV-2

ssDNA aptamer Apt31 specific to the receptor-binding domain of SARS-CoV-2 experimental SAS data

Sample:	...receptor-binding domain of SARS-CoV-2 monomer, 10 kDa Artificially synthesized DNA
Buffer:	Tris-HCl, pH: 7.4
Experiment:	SAXS data collected at 13A, Taiwan Photon Source, NSRRC on 2020 Dec 18

Structure and Interaction Based Design of Anti‐SARS‐CoV‐2 Aptamers Chemistry – A European Journal (2022)
Mironov V, Shchugoreva I, Artyushenko P, Morozov D, Borbone N, Oliviero G, Zamay T, Moryachkov R, Kolovskaya O, Lukyanenko K, Song Y, Merkuleva I, Zabluda V, Peters G, Koroleva L, Veprintsev D, Glazyr...

R_g^Guinier	1.9	nm
D_max	6.5	nm
Volume^Porod	12	nm³

SASDDU8 – ...domain architecture of the estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

Estrogen receptorERE1ERE2EstradiolhERa peptide1hERa peptide2 experimental SAS data

Sample:	...receptor dimer, 85 kDa protein ERE1 monomer, 6 kDa Homo sapiens DNA ERE2 monomer, 6 kDa Homo sapiens DNA Estradiol dimer, 0 kDa hERa peptide1 monomer, 2 kDa protein hERa peptide2 monomer, 2 kDa protein
Buffer:	10 mM CHES (pH9.5), 125 mM NaCl, 5mM KCl, 4 mM MgCl2, 50 mM arginine, 50 mM glutamate, 5 mM TCEP, 5% glycerol, 10 µm Zn acetate, 10 µM estradiol, pH: 9.5
Experiment:	SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2014 Aug 10

...domain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains. Nat Commun 9(1):3520 (2018)
Huang W, Peng Y, Kiselar J, Zhao X, Albaqami A, Mendez D, Chen Y, Chakravarthy S, Gupta S, Ralston C, Kao HY, Chance MR, Yang S

R_g^Guinier	3.8	nm
D_max	11.5	nm

SASDQ39 – ...receptor binding domain (RBD) - reservoir sample storage with liquid jet delivery measured using XFEL

Spike glycoprotein (ACE2 receptor binding domain) Kratky plot

Sample:	...receptor binding domain) monomer, 29 kDa Severe acute respiratory … protein
Buffer:	phosphate buffered saline, pH: 7.4
Experiment:	SANS data collected at SPB/SFX, European XFEL on 2021 May 14

Form factor determination of biological molecules with X-ray free electron laser small-angle scattering (XFEL-SAS). Commun Biol 6(1):1057 (2023)
Blanchet CE, Round A, Mertens HDT, Ayyer K, Graewert M, Awel S, Franke D, Dörner K, Bajt S, Bean R, Custódio TF, de Wijn R, Juncheng E, Henkel A, Gruzinov A, Jeffries CM, Kim Y, Kirkwood H, Kloos M, K...

R_g^Guinier

3.0

SASDPE4 – ...domain

P2X purinoceptor 7 experimental SAS data

Sample:	P2X purinoceptor 7 trimer, 74 kDa Homo sapiens protein
Buffer:	20 mM HEPES pH 7.5, 150 mM NaCl, 5 mM CaCl2, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Jun 4

...receptor regulation: Ca2+-calmodulin and GDP bind to the soluble P2X7 ballast domain. J Biol Chem :102495 (2022)
Sander S, Müller I, Alai MG, Nicke A, Tidow H

R_g^Guinier	3.1	nm
D_max	10.5	nm
Volume^Porod	94	nm³

SASDE59 – ...receptor type 1, IL-1RI-ECD

Interleukin-1 receptor type 1 experimental SAS data

Sample:	...receptor type 1 monomer, 37 kDa Homo sapiens protein
Buffer:	10mM HEPES, 150mM NaCl, 3% glycerol, pH: 7.2
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2017 Jul 22

...Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27(8):1296-1307.e5 (2019)
Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X

R_g^Guinier	3.0	nm
D_max	10.5	nm
Volume^Porod	63	nm³

SASDH79 – ...receptor domains 9-10

Cation-independent mannose-6-phosphate receptor experimental SAS data

Sample:	...receptor dimer, 67 kDa Homo sapiens protein
Buffer:	25 mM Tris, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2020 Jan 25

...Receptor Domains 7–11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9 Structure (2020)
Bochel A, Williams C, McCoy A, Hoppe H, Winter A, Nicholls R, Harlos K, Jones E, Berger I, Hassan A, Crump M

R_g^Guinier	3.3	nm
D_max	9.2	nm
Volume^Porod	93	nm³

SASDPD4 – Ca2+-calmodulin

Sample:	Calmodulin-1 monomer, 17 kDa Homo sapiens protein
Buffer:	20 mM HEPES pH 7.5, 150 mM NaCl, 5 mM CaCl2, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Jun 4

...receptor regulation: Ca2+-calmodulin and GDP bind to the soluble P2X7 ballast domain. J Biol Chem :102495 (2022)
Sander S, Müller I, Alai MG, Nicke A, Tidow H

R_g^Guinier	2.1	nm
D_max	6.9	nm
Volume^Porod	23	nm³

SASDH59 – ...receptor domains 9-10 wih mannose-6-phosphate

Sample:	...receptor dimer, 67 kDa Homo sapiens protein
Buffer:	25 mM Tris, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2020 Jan 25

R_g^Guinier	3.3	nm
D_max	9.1	nm
Volume^Porod	88	nm³

SASDE69 – ...receptor type 2, IL-1RII-ECD

Interleukin-1 receptor type 2 experimental SAS data

Sample:	...receptor type 2 monomer, 38 kDa Homo sapiens protein
Buffer:	10mM HEPES, 150mM NaCl, 3% glycerol, pH: 7.2
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2017 Jul 24

...Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27(8):1296-1307.e5 (2019)
Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X

R_g^Guinier	2.8	nm
D_max	9.9	nm
Volume^Porod	80	nm³

SASDPF4 – ...domain in complex with Ca2+-calmodulin

Calmodulin-1P2X purinoceptor 7 experimental SAS data

Calmodulin-1 P2X purinoceptor 7 Kratky plot

Sample:	Calmodulin-1 monomer, 17 kDa Homo sapiens protein P2X purinoceptor 7 monomer, 25 kDa Homo sapiens protein
Buffer:	20 mM HEPES pH 7.5, 150 mM NaCl, 5 mM CaCl2, pH: 7.5
Experiment:	SAXS data collected at EMBL P12, PETRA III on 2021 Jun 4

...receptor regulation: Ca2+-calmodulin and GDP bind to the soluble P2X7 ballast domain. J Biol Chem :102495 (2022)
Sander S, Müller I, Alai MG, Nicke A, Tidow H

R_g^Guinier	3.2	nm
D_max	13.5	nm
Volume^Porod	73	nm³

SASDH69 – ...receptor domains 9-10: Deglycosylated

Sample:	...receptor monomer, 34 kDa Homo sapiens protein
Buffer:	25 mM Tris, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2020 Mar 3

R_g^Guinier	2.5	nm
D_max	7.8	nm
Volume^Porod	48	nm³

SASDE79 – ...receptor 1, IL-18Rα-ECD

Interleukin-18 receptor 1 experimental SAS data

Sample:	...receptor 1 monomer, 36 kDa Homo sapiens protein
Buffer:	10mM HEPES, 150mM NaCl, 3% glycerol, pH: 7.2
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2014 Oct 3

...Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27(8):1296-1307.e5 (2019)
Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X

R_g^Guinier	3.1	nm
D_max	10.9	nm
Volume^Porod	77	nm³

SASDJ23 – ...receptor domains 9-10: Deglycosylated with mannose-6-phosphate

Sample:	...receptor monomer, 34 kDa Homo sapiens protein
Buffer:	25 mM Tris, 150 mM NaCl, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2020 Mar 3

R_g^Guinier	2.5	nm
D_max	7.8	nm
Volume^Porod	69	nm³

SASDEZ8 – ...receptor accessory protein, IL-18Rβ-ECD

Interleukin-18 receptor accessory protein experimental SAS data

Sample:	...receptor accessory protein monomer, 41 kDa Homo sapiens protein
Buffer:	10mM HEPES, 150mM NaCl, 3% glycerol, pH: 7.2
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2017 Jul 24

...Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27(8):1296-1307.e5 (2019)
Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X

R_g^Guinier	3.3	nm
D_max	11.5	nm
Volume^Porod	70	nm³

SASDE29 – ...receptor accessory protein ectodomain with RI linker

Interleukin-1 receptor accessory protein ectodomain with RI linker experimental SAS data

Sample:	...receptor accessory protein ectodomain with RI linker monomer, 41 kDa Homo sapiens protein
Buffer:	10mM HEPES, 150mM NaCl, 3% glycerol, pH: 7.2
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2016 Aug 11

...Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27(8):1296-1307.e5 (2019)
Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X

R_g^Guinier	3.0	nm
D_max	10.4	nm
Volume^Porod	76	nm³

SASDE89 – ...receptor accessory protein ectodomain with RII linker

Interleukin-1 receptor accessory protein ectodomains with RII linker experimental SAS data

Sample:	...receptor accessory protein ectodomains with RII linker monomer, 41 kDa Homo sapiens protein
Buffer:	10mM HEPES, 150mM NaCl, 3% glycerol, pH: 7.2
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2017 Jul 24

...Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27(8):1296-1307.e5 (2019)
Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X

R_g^Guinier	3.0	nm
D_max	10.7	nm
Volume^Porod	75	nm³

SASDE49 – ...receptor accessory protein ectodomains with ST2 linker

Interleukin-1 receptor accessory protein ectodomains with ST2 linker experimental SAS data

Sample:	...receptor accessory protein ectodomains with ST2 linker monomer, 41 kDa Homo sapiens protein
Buffer:	10mM HEPES, 150mM NaCl, 3% glycerol, pH: 7.2
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2017 Jul 24

...Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27(8):1296-1307.e5 (2019)
Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X

R_g^Guinier	3.1	nm
D_max	10.7	nm
Volume^Porod	76	nm³

SASDE39 – ...receptor accessory protein ectodomain with Rα linker

Interleukin-18 receptor accessory protein ectodomain with Rα linker experimental SAS data

Sample:	...receptor accessory protein ectodomain with Rα linker monomer, 41 kDa Homo sapiens protein
Buffer:	10mM HEPES, 150mM NaCl, 3% glycerol, pH: 7.2
Experiment:	SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2017 Jul 24

...Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27(8):1296-1307.e5 (2019)
Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X

R_g^Guinier	3.4	nm
D_max	11.5	nm
Volume^Porod	72	nm³

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