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37 hits found for Hopkins

SASDMZ9 – Dockerin domain-containing protein, starch adherence system 20 (Sas20), domains 1 and 2

Dockerin domain-containing protein experimental SAS data
MULTIFOXS model
Sample: Dockerin domain-containing protein monomer, 57 kDa Ruminococcus bromii protein
Buffer: phosphate buffered saline, 1 mM TCEP, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Mar 28
Sas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome Journal of Biological Chemistry :101896 (2022)
...Hopkins J, Koropatkin N
RgGuinier 5.4 nm
Dmax 20.3 nm
VolumePorod 93 nm3

SASDN22 – Dockerin domain-containing protein, starch adherence system 20 (Sas20), domain 1 with maltoheptaose

Dockerin domain-containing protein experimental SAS data
Dockerin domain-containing protein Kratky plot
Sample: Dockerin domain-containing protein monomer, 26 kDa Ruminococcus bromii protein
Buffer: phosphate buffered saline, 1 mM TCEP, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Nov 14
Sas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome Journal of Biological Chemistry :101896 (2022)
...Hopkins J, Koropatkin N
RgGuinier 2.0 nm
Dmax 7.8 nm
VolumePorod 45 nm3

SASDN32 – Dockerin domain-containing protein, starch adherence system 20 (Sas20), domain 2 with maltoheptaose

Dockerin domain-containing protein experimental SAS data
MULTIFOXS model
Sample: Dockerin domain-containing protein monomer, 26 kDa Ruminococcus bromii protein
Buffer: phosphate buffered saline, 1 mM TCEP, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Nov 14
Sas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome Journal of Biological Chemistry :101896 (2022)
...Hopkins J, Koropatkin N
RgGuinier 2.1 nm
Dmax 7.4 nm
VolumePorod 41 nm3

SASDN42 – Dockerin domain-containing protein, starch adherence system 20 (Sas20), domains 1 and 2 with maltoheptaose

Dockerin domain-containing protein experimental SAS data
Dockerin domain-containing protein Kratky plot
Sample: Dockerin domain-containing protein monomer, 26 kDa Ruminococcus bromii protein
Buffer: phosphate buffered saline, 1 mM TCEP, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Nov 14
Sas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome Journal of Biological Chemistry :101896 (2022)
...Hopkins J, Koropatkin N
RgGuinier 5.2 nm
Dmax 19.0 nm
VolumePorod 84 nm3

SASDMG4 – Arrestin-3 ERK2 fusion, monomer (Arrestin-3 fused to extracellular signal-regulated kinase 2)

Arrestin-3 fused to extracellular signal-regulated kinase 2 experimental SAS data
Arrestin-3 ERK2 fusion, monomer (Arrestin-3 fused to extracellular signal-regulated kinase 2) Rg histogram
Sample: Arrestin-3 fused to extracellular signal-regulated kinase 2 monomer, 89 kDa Bos taurus/Rattus norvegicus protein
Buffer: 20 mM MOPS pH 7.5, 150 mM NaCl, 1 mM TCEP, and 5% glycerol, pH: 7.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Mar 23
The two non-visual arrestins engage ERK2 differently. J Mol Biol :167465 (2022)
...Hopkins J, Zhuo Y, Zheng C, Perez I, Schultz KM, Vishnivetskiy SA, Kaya AI, Sharma P, Dalby KN, Young Chung K, Klug CS, Gurevich VV, Iverson TM
RgGuinier 3.6 nm
Dmax 14.0 nm

SASDMH4 – Arrestin-3 ERK2 fusion, dimer (Arrestin-3 fused to extracellular signal-regulated kinase 2)

Arrestin-3 fused to extracellular signal-regulated kinase 2 experimental SAS data
Arrestin-3 fused to extracellular signal-regulated kinase 2 Kratky plot
Sample: Arrestin-3 fused to extracellular signal-regulated kinase 2 dimer, 178 kDa Bos taurus/Rattus norvegicus protein
Buffer: 20 mM MOPS pH 7.5, 150 mM NaCl, 1 mM TCEP, and 5% glycerol, pH: 7.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Mar 23
The two non-visual arrestins engage ERK2 differently. J Mol Biol :167465 (2022)
...Hopkins J, Zhuo Y, Zheng C, Perez I, Schultz KM, Vishnivetskiy SA, Kaya AI, Sharma P, Dalby KN, Young Chung K, Klug CS, Gurevich VV, Iverson TM
RgGuinier 4.3 nm
Dmax 16.0 nm

SASDHT5 – Human Carbonic Anhydrase IX

Carbonic anhydrase 9 experimental SAS data
Human Carbonic Anhydrase IX Rg histogram
Sample: Carbonic anhydrase 9 monomer, 41 kDa Homo sapiens protein
Buffer: 50 mM Tris, 150 mM NaCl, pH: 7.5
Experiment: SAXS data collected at G1, Cornell High Energy Synchrotron Source (CHESS) on 2015 Nov 16
Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX. Int J Mol Sci 21(15) (2020)
...Hopkins JB, Knecht W, McKenna R, Fisher SZ
RgGuinier 2.5 nm
Dmax 8.5 nm
VolumePorod 71 nm3

SASDLM8 – Human apo Nocturnin - Extended

Nocturnin experimental SAS data
Human apo Nocturnin - Extended Rg histogram
Sample: Nocturnin monomer, 41 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, 10% glycerol, 5 mM MgCl2, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Feb 7
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics. Biochemistry (2022)
...Hopkins JB, Joachimiak LA, Green CB
RgGuinier 2.9 nm
Dmax 12.3 nm
VolumePorod 85 nm3

SASDLN8 – Human apo Nocturnin - Compact

Nocturnin experimental SAS data
Human apo Nocturnin - Compact Rg histogram
Sample: Nocturnin monomer, 41 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, 10% glycerol, 5 mM MgCl2, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Feb 7
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics. Biochemistry (2022)
...Hopkins JB, Joachimiak LA, Green CB
RgGuinier 2.4 nm
Dmax 9.6 nm
VolumePorod 76 nm3

SASDLP8 – Human apo Nocturnin - Deletion construct (Δ107-120) - Extended

Nocturnin - Deletion construct - Δ107-120 experimental SAS data
Human apo Nocturnin - Deletion construct (Δ107-120) - Extended Rg histogram
Sample: Nocturnin - Deletion construct - Δ107-120 monomer, 40 kDa protein
Buffer: 50 mM HEPES, 150 mM KCl, 10% glycerol, 5 mM MgCl2, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Feb 7
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics. Biochemistry (2022)
...Hopkins JB, Joachimiak LA, Green CB
RgGuinier 2.8 nm
Dmax 11.2 nm
VolumePorod 72 nm3

SASDLQ8 – Human apo Nocturnin - Deletion construct (Δ107-120) - Compact

Nocturnin - Deletion construct - Δ107-120 experimental SAS data
Human apo Nocturnin - Deletion construct (Δ107-120) - Compact Rg histogram
Sample: Nocturnin - Deletion construct - Δ107-120 monomer, 40 kDa protein
Buffer: 50 mM HEPES, 150 mM KCl, 10% glycerol, 5 mM MgCl2, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Feb 7
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics. Biochemistry (2022)
...Hopkins JB, Joachimiak LA, Green CB
RgGuinier 2.5 nm
Dmax 10.0 nm
VolumePorod 80 nm3

SASDLR8 – Human apo Nocturnin - N terminus truncated (118-NOCT)

Nocturnin - N terminus truncated (118-NOCT) experimental SAS data
EOM/RANCH model
Sample: Nocturnin - N terminus truncated (118-NOCT) monomer, 36 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM KCl, 10% glycerol, 5 mM MgCl2, 1 mM TCEP, pH: 7.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Feb 7
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics. Biochemistry (2022)
...Hopkins JB, Joachimiak LA, Green CB
RgGuinier 2.3 nm
Dmax 10.3 nm
VolumePorod 63 nm3

SASDMX9 – Dockerin domain-containing protein, starch adherence system 20 (Sas20), domain 1

Dockerin domain-containing protein experimental SAS data
MULTIFOXS model
Sample: Dockerin domain-containing protein monomer, 26 kDa Ruminococcus bromii protein
Buffer: phosphate buffered saline, 1 mM TCEP, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Mar 28
Sas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome Journal of Biological Chemistry :101896 (2022)
...Hopkins J, Koropatkin N
RgGuinier 2.1 nm
Dmax 10.3 nm
VolumePorod 42 nm3

SASDMY9 – Dockerin domain-containing protein, starch adherence system 20 (Sas20), domain 2

Dockerin domain-containing protein experimental SAS data
MULTIFOXS model
Sample: Dockerin domain-containing protein monomer, 26 kDa Ruminococcus bromii protein
Buffer: phosphate buffered saline, 1 mM TCEP, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Mar 28
Sas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome Journal of Biological Chemistry :101896 (2022)
...Hopkins J, Koropatkin N
RgGuinier 2.3 nm
Dmax 7.8 nm
VolumePorod 35 nm3

SASDMJ6 – cMyc-8

cMyc promoter 8-tract G-quadruplex experimental SAS data
CHIMERA model
Sample: cMyc promoter 8-tract G-quadruplex monomer, 11 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 19
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.4 nm
Dmax 4.6 nm
VolumePorod 13 nm3

SASDHY9 – Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (amino acids 38-408): DHPH

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein experimental SAS data
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (amino acids 38-408): DHPH Rg histogram
Sample: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein monomer, 43 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300mM NaCl, pH: 8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Oct 19
The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity andcontributes to membrane binding. J Biol Chem (2020)
...Hopkins JB, Plescia CB, Allgood SR, Kane MA, Cash JN, Stahelin RV, Tesmer JJG
RgGuinier 2.8 nm
Dmax 10.5 nm
VolumePorod 64 nm3

SASDMM6 – cMyc-12

cMyc promoter 12-tract G-quadruplex experimental SAS data
cMyc promoter 12-tract G-quadruplex Kratky plot
Sample: cMyc promoter 12-tract G-quadruplex monomer, 23 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 22
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 2.3 nm
Dmax 8.4 nm
VolumePorod 29 nm3

SASDHW9 – Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (amino acids 38-499): DHPHDEP1

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein experimental SAS data
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (amino acids 38-499): DHPHDEP1 Rg histogram
Sample: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein monomer, 54 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Oct 19
The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity andcontributes to membrane binding. J Biol Chem (2020)
...Hopkins JB, Plescia CB, Allgood SR, Kane MA, Cash JN, Stahelin RV, Tesmer JJG
RgGuinier 3.0 nm
Dmax 10.4 nm
VolumePorod 77 nm3

SASDM36 – c-Myc12 DnaseI Treated G-quadruplex

c-Myc 12-tract G-quadruplex monomer Dnase I treated experimental SAS data
CHIMERA model
Sample: c-Myc 12-tract G-quadruplex monomer Dnase I treated monomer, 22 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Sep 29
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 2.0 nm
Dmax 6.7 nm
VolumePorod 25 nm3

SASDHX9 – Phosphorylated phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (amino acids 38-499): pDHPHDEP1

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 experimental SAS data
Phosphorylated phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (amino acids 38-499): pDHPHDEP1 Rg histogram
Sample: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 monomer, 54 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Oct 19
The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity andcontributes to membrane binding. J Biol Chem (2020)
...Hopkins JB, Plescia CB, Allgood SR, Kane MA, Cash JN, Stahelin RV, Tesmer JJG
RgGuinier 3.0 nm
Dmax 10.5 nm
VolumePorod 75 nm3

SASDMK6 – cKit-8

cKit promoter 8-tract G-quadruplex experimental SAS data
CHIMERA model
Sample: cKit promoter 8-tract G-quadruplex monomer, 12 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 19
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.5 nm
Dmax 4.7 nm
VolumePorod 15 nm3

SASDMN6 – cKit-12

cKit promoter 12-tract G-quadruplex experimental SAS data
CHIMERA model
Sample: cKit promoter 12-tract G-quadruplex monomer, 20 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 22
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 2.5 nm
Dmax 9.0 nm
VolumePorod 26 nm3

SASDM46 – c-Kit12 DNase I Digest

c-Kit 12-tract G-quadruplex monomer Dnase I treated experimental SAS data
c-Kit 12-tract G-quadruplex monomer Dnase I treated Kratky plot
Sample: c-Kit 12-tract G-quadruplex monomer Dnase I treated monomer, 20 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Sep 29
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.6 nm
Dmax 5.7 nm
VolumePorod 16 nm3

SASDML6 – kRas-8

kRas promoter 8-tract G-quadruplex experimental SAS data
CHIMERA model
Sample: kRas promoter 8-tract G-quadruplex monomer, 14 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Feb 19
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.7 nm
Dmax 5.6 nm
VolumePorod 16 nm3

SASDM56 – 2KZD

TERT promoter G-quadruplex antiparallel experimental SAS data
CHIMERA model
Sample: TERT promoter G-quadruplex antiparallel monomer, 6 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 13
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.2 nm
Dmax 3.6 nm
VolumePorod 7 nm3

SASDM76 – 201D

DNA oligonucleotide G4(T4G4)3 experimental SAS data
CHIMERA model
Sample: DNA oligonucleotide G4(T4G4)3 monomer, 9 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 12
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.3 nm
Dmax 4.1 nm
VolumePorod 10 nm3

SASDM86 – 6GH0

cKIT 2-tetrad promoter GQ antiparallel experimental SAS data
CHIMERA model
Sample: cKIT 2-tetrad promoter GQ antiparallel monomer, 7 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 21
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.0 nm
Dmax 3.1 nm
VolumePorod 8 nm3

SASDM96 – 2GKU

human telomere 24mer hybrid-1 experimental SAS data
CHIMERA model
Sample: human telomere 24mer hybrid-1 monomer, 8 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 11
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.2 nm
Dmax 3.8 nm
VolumePorod 8 nm3

SASDMA6 – 5I2V

kRas promoter GQ hybrid experimental SAS data
CHIMERA model
Sample: kRas promoter GQ hybrid monomer, 7 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.3 nm
Dmax 4.9 nm
VolumePorod 10 nm3

SASDMB6 – 6L92

WNT promoter GQ hybrid form experimental SAS data
CHIMERA model
Sample: WNT promoter GQ hybrid form monomer, 7 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 21
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.2 nm
Dmax 3.9 nm
VolumePorod 8 nm3

SASDMC6 – 2KQG

cKit promoter GQ parallel experimental SAS data
CHIMERA model
Sample: cKit promoter GQ parallel monomer, 7 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.6 nm
Dmax 3.2 nm
VolumePorod 14 nm3

SASDMD6 – 2LBY

cMyc promoter GQ parallel experimental SAS data
CHIMERA model
Sample: cMyc promoter GQ parallel monomer, 6 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.2 nm
Dmax 3.9 nm
VolumePorod 7 nm3

SASDME6 – 6NEB

cMyc promoter GQ 1:6:1 loop parallel experimental SAS data
CHIMERA model
Sample: cMyc promoter GQ 1:6:1 loop parallel monomer, 9 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.4 nm
Dmax 4.5 nm
VolumePorod 10 nm3

SASDMF6 – 1XAV

cMyc promoter modified GQ parallel experimental SAS data
CHIMERA model
Sample: cMyc promoter modified GQ parallel monomer, 7 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Aug 11
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.3 nm
Dmax 4.1 nm
VolumePorod 9 nm3

SASDM66 – 2KZE

TERT promoter G-quadruplex parallel experimental SAS data
CHIMERA model
Sample: TERT promoter G-quadruplex parallel monomer, 6 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2021 Aug 11
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.3 nm
Dmax 4.2 nm
VolumePorod 8 nm3

SASDMG6 – 5CMX

two-tetrad antiparallel GQ with duplex junction experimental SAS data
CHIMERA model
Sample: two-tetrad antiparallel GQ with duplex junction monomer, 10 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Oct 3
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.5 nm
Dmax 5.2 nm
VolumePorod 12 nm3

SASDMH6 – 2M27

VEGF promoter GQ parallel experimental SAS data
CHIMERA model
Sample: VEGF promoter GQ parallel monomer, 7 kDa synthetic construct DNA
Buffer: 6 mM Na2HPO4, 2 mM NaH2PO4, 1 mM Na2EDTA, 185 mM KCl, pH: 7.2
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 20
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences. Nucleic Acids Res (2022)
...Hopkins JB, Chaires JB, Trent JO
RgGuinier 1.3 nm
Dmax 3.8 nm
VolumePorod 8 nm3