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155 hits found for Li

SASDR32 – Human derived autoantibody mAb2G7 at pH 8.0

Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VHHuman derived autoantibody mAb2G7 light chain, mAb2G7 VL experimental SAS data
Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH Human derived autoantibody mAb2G7 light chain, mAb2G7 VL Kratky plot
Sample: Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein
...light chain, mAb2G7 VL dimer, 51 kDa protein
Buffer: ...line, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2022 Dec 8
...litis. Nat Struct Mol Biol (2024)
...Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
RgGuinier 5.0 nm
Dmax 16.0 nm
VolumePorod 260 nm3

SASDR42 – Human derived autoantibody mAb5F6 at pH 8.0

Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VHHuman derived autoantibody mAb2G7 light chain, mAb2G7 VL experimental SAS data
Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH Human derived autoantibody mAb2G7 light chain, mAb2G7 VL Kratky plot
Sample: Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein
...light chain, mAb2G7 VL dimer, 51 kDa protein
Buffer: ...line, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2022 Dec 8
...litis. Nat Struct Mol Biol (2024)
...Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
RgGuinier 5.0 nm
Dmax 15.8 nm
VolumePorod 252 nm3

SASDR52 – Human GluN1-GluN2A NMDA receptor at pH 8.0

Glutamate receptor ionotropic, NMDA 1Glutamate receptor ionotropic, NMDA 2A experimental SAS data
Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2A Kratky plot
Sample: Glutamate receptor ionotropic, NMDA 1 dimer, 193 kDa Homo sapiens protein
Glutamate receptor ionotropic, NMDA 2A dimer, 191 kDa Homo sapiens protein
Buffer: 150 mM NaCl, 0.1% digitonin, 5 µM Cholesteryl Hemisuccinate TRIS Salt, 0.1 mM CHAPSO, 50 µM EDTA,1 mM Gly/Glu, 20 mM HEPES, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2022 Dec 8
...litis. Nat Struct Mol Biol (2024)
...Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
RgGuinier 6.6 nm
Dmax 20.4 nm
VolumePorod 1180 nm3

SASDR62 – Human GluN1-GluN2A NMDA receptor in complex with human derived autoantibody mAb2G7 at pH 8.0

Glutamate receptor ionotropic, NMDA 1Glutamate receptor ionotropic, NMDA 2AHuman derived autoantibody mAb2G7 heavy chain, mAb2G7 VHHuman derived autoantibody mAb2G7 light chain, mAb2G7 VL experimental SAS data
Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2A Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH Human derived autoantibody mAb2G7 light chain, mAb2G7 VL Kratky plot
Sample: Glutamate receptor ionotropic, NMDA 1 dimer, 193 kDa Homo sapiens protein
Glutamate receptor ionotropic, NMDA 2A dimer, 191 kDa Homo sapiens protein
Human derived autoantibody mAb2G7 heavy chain, mAb2G7 VH dimer, 103 kDa protein
...light chain, mAb2G7 VL dimer, 51 kDa protein
Buffer: 150 mM NaCl, 0.1% digitonin, 5 µM Cholesteryl Hemisuccinate TRIS Salt, 0.1 mM CHAPSO, 50 µM EDTA,1 mM Gly/Glu, 20 mM HEPES, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2022 Dec 8
...litis. Nat Struct Mol Biol (2024)
...Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
RgGuinier 7.7 nm
Dmax 25.4 nm
VolumePorod 1260 nm3

SASDR72 – Human GluN1-GluN2A NMDA receptor in complex with human derived autoantibody mAb5F6 at pH 8.0

Glutamate receptor ionotropic, NMDA 1Glutamate receptor ionotropic, NMDA 2AHuman derived autoantibody mAb5F6 heavy chain, mAb5F6 VHHuman derived autoantibody mAb5F6 light chain, mAb5F6 VL experimental SAS data
Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2A Human derived autoantibody mAb5F6 heavy chain, mAb5F6 VH Human derived autoantibody mAb5F6 light chain, mAb5F6 VL Kratky plot
Sample: Glutamate receptor ionotropic, NMDA 1 dimer, 193 kDa Homo sapiens protein
Glutamate receptor ionotropic, NMDA 2A dimer, 191 kDa Homo sapiens protein
Human derived autoantibody mAb5F6 heavy chain, mAb5F6 VH dimer, 104 kDa Homo sapiens protein
...light chain, mAb5F6 VL dimer, 52 kDa protein
Buffer: 150 mM NaCl, 0.1% digitonin, 5 µM Cholesteryl Hemisuccinate TRIS Salt, 0.1 mM CHAPSO, 50 µM EDTA,1 mM Gly/Glu, 20 mM HEPES, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2022 Dec 8
...litis. Nat Struct Mol Biol (2024)
...Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
RgGuinier 9.9 nm
Dmax 31.7 nm
VolumePorod 2500 nm3

SASDUA2 – The Z-DNA binding domains Zαβ of Z-DNA binding protein 1 (monomer)

Z-DNA-binding protein 1 experimental SAS data
DAMMIF model
Sample: Z-DNA-binding protein 1 monomer, 18 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2018 Mar 23
ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction. Cell Death Dis 15(7):487 (2024)
...Liu X, Shen Y, Huang J, Su Z, Li J
RgGuinier 2.1 nm
Dmax 9.0 nm
VolumePorod 19 nm3

SASDUB2 – The Z-DNA binding domains Zαβ of Z-DNA binding protein 1 (dimer)

Z-DNA-binding protein 1 experimental SAS data
DAMMIF model
Sample: Z-DNA-binding protein 1 dimer, 37 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2018 Mar 23
ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction. Cell Death Dis 15(7):487 (2024)
...Liu X, Shen Y, Huang J, Su Z, Li J
RgGuinier 3.1 nm
Dmax 13.0 nm
VolumePorod 48 nm3

SASDBF2 – ...ligonucleotide

40bp long dsDNA-Sa Oligonucleotide experimental SAS data
DAMMIN model
Sample: ...ligonucleotide monomer, 25 kDa DNA
Buffer: 0.5 x Tris/Borate/EDTA (TBE), pH:
Experiment: SAXS data collected at BM29, ESRF on 2015 Aug 28
...lity regulator AbfR1 in Sulfolobus acidocaldarius. Mol Microbiol 105(5):777-793 (2017)
Li L, Banerjee A, Bischof LF, Maklad HR, Hoffmann L, Henche AL, Veliz F, Bildl W, Schulte U, Orell A, Essen LO, Peeters E, Albers SV
RgGuinier 3.6 nm
Dmax 12.0 nm

SASDUF2 – ...linositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1-DH/PH-DEP1 (WT))

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein experimental SAS data
EOM/RANCH model
Sample: ...linositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein monomer, 54 kDa Homo sapiens protein
Buffer: 20 mM HEPES pH 7, 300 mM NaCl, 2% glycerol, 2 mM DTT, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Oct 8
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 ...Life 12 (2024)
...Li S, Chen C, Cianfrocco M, Silvio Gutkind J, Cash J, Tesmer J
RgGuinier 3.0 nm
Dmax 9.7 nm
VolumePorod 79 nm3

SASDBG2 – Wild-type archaeal biofilm regulator 1 (ABfR1: Transcriptional regulator ArsR family).

Wild-type archaeal biofilm regulator 1 (ABfR1: Transcriptional regulator ArsR family). experimental SAS data
DAMMIN model
Sample: Wild-type archaeal biofilm regulator 1 (ABfR1: Transcriptional regulator ArsR family). dimer, 26 kDa Sulfolobus acidocaldarius protein
Buffer: 20 mM HEPES 200 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2015 Aug 27
...lity regulator AbfR1 in Sulfolobus acidocaldarius. Mol Microbiol 105(5):777-793 (2017)
Li L, Banerjee A, Bischof LF, Maklad HR, Hoffmann L, Henche AL, Veliz F, Bildl W, Schulte U, Orell A, Essen LO, Peeters E, Albers SV
RgGuinier 2.6 nm
Dmax 9.8 nm
VolumePorod 47 nm3

SASDUG2 – ...linositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein A170K mutant (P-Rex1-DH/PH-DEP1-A170K)

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (A170K) experimental SAS data
EOM/RANCH model
Sample: ...linositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (A170K) monomer, 54 kDa Homo sapiens protein
Buffer: 20 mM HEPES pH 7, 300 mM NaCl, 2% glycerol, 2 mM DTT, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 24
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 ...Life 12 (2024)
...Li S, Chen C, Cianfrocco M, Silvio Gutkind J, Cash J, Tesmer J
RgGuinier 2.9 nm
Dmax 9.0 nm
VolumePorod 76 nm3

SASDBH2 – Mutant archaeal biofilm regulator 1 (ABfR1) phosphomimic Y84E S87D

Archaeal biofilm regulator 1 (AbfR1) mutant Y84E S87D phosphomimic mutant experimental SAS data
DAMMIN model
Sample: Archaeal biofilm regulator 1 (AbfR1) mutant Y84E S87D phosphomimic mutant dimer, 26 kDa Sulfolobus acidocaldarius protein
Buffer: 20 mM HEPES 200 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2015 Aug 27
...lity regulator AbfR1 in Sulfolobus acidocaldarius. Mol Microbiol 105(5):777-793 (2017)
Li L, Banerjee A, Bischof LF, Maklad HR, Hoffmann L, Henche AL, Veliz F, Bildl W, Schulte U, Orell A, Essen LO, Peeters E, Albers SV
RgGuinier 2.6 nm
Dmax 9.5 nm
VolumePorod 51 nm3

SASDUH2 – ...linositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein L177E mutant (P-Rex1-DH/PH-DEP1-L177E)

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (L177E) experimental SAS data
EOM/RANCH model
Sample: ...linositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (L177E) monomer, 54 kDa Homo sapiens protein
Buffer: 20 mM HEPES pH 7, 300 mM NaCl, 2% glycerol, 2 mM DTT, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Oct 8
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 ...Life 12 (2024)
...Li S, Chen C, Cianfrocco M, Silvio Gutkind J, Cash J, Tesmer J
RgGuinier 3.1 nm
Dmax 11.0 nm
VolumePorod 88 nm3

SASDBJ2 – ...ligonucleotide.

40bp long dsDNA-Sa OligonucleotideWild-type archaeal biofilm regulator 1 (ABfR1: Transcriptional regulator ArsR family). experimental SAS data
DAMMIN model
Sample: ...ligonucleotide monomer, 25 kDa DNA
Wild-type archaeal biofilm regulator 1 (ABfR1: Transcriptional regulator ArsR family). dimer, 26 kDa Sulfolobus acidocaldarius protein
Buffer: 0.5 x Tris/Borate/EDTA (TBE), pH:
Experiment: SAXS data collected at BM29, ESRF on 2015 Aug 27
...lity regulator AbfR1 in Sulfolobus acidocaldarius. Mol Microbiol 105(5):777-793 (2017)
Li L, Banerjee A, Bischof LF, Maklad HR, Hoffmann L, Henche AL, Veliz F, Bildl W, Schulte U, Orell A, Essen LO, Peeters E, Albers SV
RgGuinier 3.0 nm
Dmax 11.8 nm

SASDUJ2 – ...linositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein I409A mutant (P-Rex1-DH/PH-DEP1-I409A)

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (I409A) experimental SAS data
EOM/RANCH model
Sample: ...linositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (I409A) monomer, 54 kDa Homo sapiens protein
Buffer: 20 mM HEPES pH 7, 300 mM NaCl, 2% glycerol, 2 mM DTT, pH: 7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Oct 8
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 ...Life 12 (2024)
...Li S, Chen C, Cianfrocco M, Silvio Gutkind J, Cash J, Tesmer J
RgGuinier 3.0 nm
Dmax 10.4 nm
VolumePorod 79 nm3

SASDUL2 – mRNA capping enzyme small subunit

Virus termination factor small subunit experimental SAS data
DAMFILT model
Sample: Virus termination factor small subunit monomer, 33 kDa Monkeypox virus (strain … protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2024 Jan 4
Structural basis of the monkeypox virus mRNA cap N7 methyltransferase complex. Emerg Microbes Infect 13(1):2369193 (2024)
...Li J
RgGuinier 2.4 nm
Dmax 6.8 nm
VolumePorod 51 nm3

SASDUM2 – mRNA capping enzyme MTase

Virus termination factor small subunitmRNA-capping enzyme catalytic subunit experimental SAS data
DAMFILT model
Sample: Virus termination factor small subunit monomer, 33 kDa Monkeypox virus (strain … protein
mRNA-capping enzyme catalytic subunit monomer, 35 kDa Monkeypox virus (strain … protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2024 Jan 4
Structural basis of the monkeypox virus mRNA cap N7 methyltransferase complex. Emerg Microbes Infect 13(1):2369193 (2024)
...Li J
RgGuinier 2.9 nm
Dmax 10.1 nm
VolumePorod 106 nm3

SASDFJ3 – Maltose binding protein-SpoIVB peptidase fusion (MBP-SpoIVB)

SpoIVB peptidase (MBP fusion) experimental SAS data
CHIMERA model
Sample: SpoIVB peptidase (MBP fusion) monomer, 80 kDa ...lis protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 5% glycerol, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2018 Jul 12
Solution Structure of SpoIVB Reveals Mechanism of PDZ Domain-Regulated Protease Activity. Front Microbiol 10:1232 (2019)
...Li J, Jiang L, Huang M
RgGuinier 3.7 nm
Dmax 15.6 nm
VolumePorod 96 nm3

SASDKK3 – SEC-SAXS of Presequence Protease (PreP)

Presequence protease, mitochondrial experimental SAS data
Presequence protease, mitochondrial Kratky plot
Sample: Presequence protease, mitochondrial monomer, 115 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 7.7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 4
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nature Communications 13(1) (2022)
Liang W, Wijaya J, Wei H, Noble A, Mancl J, Mo S, Lee D, Lin King J, Pan M, Liu C, Koehler C, Zhao M, Potter C, Carragher B, Li S, Tang W
RgGuinier 3.2 nm
Dmax 9.1 nm
VolumePorod 170 nm3

SASDKL3 – SEC-SAXS of Presequence Protease (PreP) with inhibitor MitoBloCK-60 (MB-60)

Presequence protease, mitochondrial experimental SAS data
Presequence protease, mitochondrial Kratky plot
Sample: Presequence protease, mitochondrial monomer, 115 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 7.7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 7
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nature Communications 13(1) (2022)
Liang W, Wijaya J, Wei H, Noble A, Mancl J, Mo S, Lee D, Lin King J, Pan M, Liu C, Koehler C, Zhao M, Potter C, Carragher B, Li S, Tang W
RgGuinier 3.1 nm
Dmax 9.1 nm
VolumePorod 165 nm3

SASDKM3 – SEC-SAXS of Presequence Protease (PreP) with pre-sequence of citrate synthase (1-27)

Presequence protease, mitochondrialCitrate synthase, mitochondrial experimental SAS data
Presequence protease, mitochondrial Citrate synthase, mitochondrial Kratky plot
Sample: Presequence protease, mitochondrial monomer, 115 kDa Homo sapiens protein
Citrate synthase, mitochondrial monomer, 3 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl , 20 mM EDTA, pH: 7.7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Nov 4
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nature Communications 13(1) (2022)
Liang W, Wijaya J, Wei H, Noble A, Mancl J, Mo S, Lee D, Lin King J, Pan M, Liu C, Koehler C, Zhao M, Potter C, Carragher B, Li S, Tang W
RgGuinier 3.1 nm
Dmax 8.7 nm
VolumePorod 165 nm3

SASDNM3 – Sperm-expressed surface protein

Sperm acrosome membrane-associated protein 6 experimental SAS data
DAMFILT model
Sample: Sperm acrosome membrane-associated protein 6 monomer, 25 kDa Homo sapiens protein
Buffer: 2.7 mM KCl, 137 mM NaCl, 10 mM Na2HPO4, 1.8 mM KH2PO4, pH: 7.4
Experiment: SAXS data collected at ...LiX), ...Light Source II (NSLS-II) on 2021 Dec 11
SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins. Commun Biol 5(1):984 (2022)
...Li S, Gawol D, Byrnes J, Usón I, Ziyyat A, Lee JE
RgGuinier 3.0 nm
Dmax 9.5 nm
VolumePorod 34 nm3

SASDKN3 – SEC-SAXS of Presequence Protease (PreP) with Amyloid beta precursor protein (1-40)

Presequence protease, mitochondrialAmyloid-beta precursor protein experimental SAS data
Presequence protease, mitochondrial Amyloid-beta precursor protein Kratky plot
Sample: Presequence protease, mitochondrial monomer, 115 kDa Homo sapiens protein
Amyloid-beta precursor protein monomer, 4 kDa Homo sapiens protein
Buffer: 20 mM Tris, 100 mM NaCl , 20 mM EDTA, pH: 7.7
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2020 Mar 7
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nature Communications 13(1) (2022)
Liang W, Wijaya J, Wei H, Noble A, Mancl J, Mo S, Lee D, Lin King J, Pan M, Liu C, Koehler C, Zhao M, Potter C, Carragher B, Li S, Tang W
RgGuinier 3.0 nm
Dmax 8.5 nm
VolumePorod 175 nm3

SASDPT3 – Histone-lysine N-methyltransferase multi protein complex: MLL1-WDR5-RBBP5-ASH2L

Histone-lysine N-methyltransferase 2AWD repeat-containing protein 5Retinoblastoma-binding protein 5Set1/Ash2 histone methyltransferase complex subunit ASH2 experimental SAS data
Histone-lysine N-methyltransferase 2A WD repeat-containing protein 5 Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Kratky plot
Sample: Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein
WD repeat-containing protein 5 monomer, 37 kDa Homo sapiens protein
Retinoblastoma-binding protein 5 monomer, 59 kDa Homo sapiens protein
Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein
Buffer: 25 mM HEPES, 150 mM NaCl, 1 mM TECP, pH: 7.4
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2021 Feb 1
...lizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates. iScience 25(9):104948 (2022)
...Li Y, Xu Y, Zheng Y, He W, Li N, Zheng J, Zhuang M, Quan S, Chen Y
RgGuinier 5.2 nm
Dmax 18.5 nm
VolumePorod 386 nm3

SASDMU3 – Overall conformation and interdomain arrangement of Vibrio collagenase VhaC in solution.

Vibrio collagenase VhaC experimental SAS data
CORAL model
Sample: Vibrio collagenase VhaC monomer, 90 kDa Vibrio harveyi protein
Buffer: 10 mM Tris-HCl, 100 mM NaCl, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2021 Jan 1
Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis. Nat Commun 13(1):566 (2022)
...Liu SC, Liu G, Zhang X, Li CY, Peng M, Li F, Li S, Chen Y, Chen XL, Zhang YZ
RgGuinier 4.3 nm
Dmax 17.6 nm
VolumePorod 148 nm3

SASDPU3 – Histone-lysine N-methyltransferase multi protein complex bound to protein dpy-30 homologue: MLL1-WDR5-RBBP5-ASH2L-DPY30

Histone-lysine N-methyltransferase 2AWD repeat-containing protein 5Retinoblastoma-binding protein 5Set1/Ash2 histone methyltransferase complex subunit ASH2Protein dpy-30 homolog experimental SAS data
Histone-lysine N-methyltransferase 2A WD repeat-containing protein 5 Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Protein dpy-30 homolog Kratky plot
Sample: Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein
WD repeat-containing protein 5 monomer, 37 kDa Homo sapiens protein
Retinoblastoma-binding protein 5 monomer, 59 kDa Homo sapiens protein
Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein
Protein dpy-30 homolog dimer, 23 kDa Homo sapiens protein
Buffer: 25 mM HEPES, 150 mM NaCl, 1 mM TECP, pH: 7.4
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2021 Feb 1
...lizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates. iScience 25(9):104948 (2022)
...Li Y, Xu Y, Zheng Y, He W, Li N, Zheng J, Zhuang M, Quan S, Chen Y
RgGuinier 5.4 nm
Dmax 17.5 nm
VolumePorod 411 nm3

SASDAV3 – Geminin:Cdt1 2:1 heterotrimer

GemininDNA replication factor Cdt1 experimental SAS data
CRYSOL model
Sample: Geminin dimer, 47 kDa Homo sapiens protein
...lication factor Cdt1 monomer, 60 kDa Homo sapiens protein
Buffer: 25 mM Tris75 200 mM NaCl, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2006 Aug 13
...lication licensing. Proc Natl Acad Sci U S A 106(47):19807-12 (2009)
...Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A
RgGuinier 2.9 nm
Dmax 10.0 nm
VolumePorod 70 nm3

SASDAW3 – Geminin:Cdt1 4:2 heterohexamer

GemininDNA replication factor Cdt1 experimental SAS data
CRYSOL model
Sample: Geminin dimer, 47 kDa Homo sapiens protein
...lication factor Cdt1 monomer, 60 kDa Homo sapiens protein
Buffer: 25 mM Tris75 200 mM NaCl, pH: 7.5
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2006 Oct 5
...lication licensing. Proc Natl Acad Sci U S A 106(47):19807-12 (2009)
...Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A
RgGuinier 3.8 nm
Dmax 14.0 nm
VolumePorod 120 nm3

SASDJW3 – YraP from Acinetobacter baumannii full-length, minus signal-peptide and acyl anchoring cysteine

BON domain protein experimental SAS data
DAMMIF model
Sample: BON domain protein decamer, 229 kDa Acinetobacter baumannii protein
Buffer: 20 mM Tris, 150 mM NaCl, 0.03 % NaN3, 5.0 % glycerol, pH: 7.8
Experiment: SAXS data collected at SAXS/WAXS, ...lian Synchrotron on 2017 Apr 11
...lized Decamer That Supports Outer Envelope Function. mBio :e0148021 (2021)
...Li J, Heinz E, Lithgow T
RgGuinier 4.7 nm
Dmax 16.4 nm
VolumePorod 546 nm3

SASDJX3 – YraP from Acinetobacter baumannii full-length, minus signal-peptide and 27 N-terminal amino acids

BON domain protein experimental SAS data
DAMMIF model
Sample: BON domain protein monomer, 20 kDa Acinetobacter baumannii protein
Buffer: 20 mM Tris HCl, 150 nM NaCl, 0.02 % NaN3, 5% glycerol, pH: 7.8
Experiment: SAXS data collected at SAXS/WAXS, ...lian Synchrotron on 2017 Apr 11
...lized Decamer That Supports Outer Envelope Function. mBio :e0148021 (2021)
...Li J, Heinz E, Lithgow T
RgGuinier 3.1 nm
Dmax 10.8 nm
VolumePorod 49 nm3

SASDG54 – Human macrophage mannose receptor 1 protein

Macrophage mannose receptor 1 experimental SAS data
ITASSER model
Sample: Macrophage mannose receptor 1 dimer, 315 kDa Mouse myeloma cell … protein
Buffer: 50mM Hepes, 100mM NaCl, 1mM DTT, pH: 7
Experiment: SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2016 Apr 15
Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses. Sci Transl Med 12(530) (2020)
...Li D, Calvo R, Dashnyam M, Singh A, Guerin T, White J, Ravichandran S, Kumar P, Talsania K, Chen V, Ghebremedhin A, Karanam B, Bin Salam A, Amin R, Odzorig T, Aiken T, Nguyen V, Bian Y, Zarif JC, de G...
RgGuinier 7.9 nm
Dmax 30.1 nm
VolumePorod 584 nm3

SASDGD4 – ...lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-381)

Retinoblastoma-binding protein 5Histone-lysine N-methyltransferase 2AWD repeat-containing protein 5Set1/Ash2 histone methyltransferase complex subunit ASH2 experimental SAS data
Retinoblastoma-binding protein 5 Histone-lysine N-methyltransferase 2A WD repeat-containing protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Kratky plot
Sample: Retinoblastoma-binding protein 5 monomer, 42 kDa Homo sapiens protein
Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein
WD repeat-containing protein 5 monomer, 34 kDa Homo sapiens protein
Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein
Buffer: 300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2019 Jun 22
The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res (2019)
...Li T, Li Y, Li M, Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y
RgGuinier 5.7 nm
Dmax 18.6 nm
VolumePorod 360 nm3

SASDGE4 – ...lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-480)

Histone-lysine N-methyltransferase 2AWD repeat-containing protein 5Set1/Ash2 histone methyltransferase complex subunit ASH2Retinoblastoma-binding protein 5 experimental SAS data
Histone-lysine N-methyltransferase 2A WD repeat-containing protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Retinoblastoma-binding protein 5 Kratky plot
Sample: Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein
WD repeat-containing protein 5 monomer, 34 kDa Homo sapiens protein
Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein
Retinoblastoma-binding protein 5 monomer, 53 kDa Homo sapiens protein
Buffer: 300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2019 Jun 22
The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res (2019)
...Li T, Li Y, Li M, Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y
RgGuinier 5.0 nm
Dmax 15.3 nm
VolumePorod 256 nm3

SASDGF4 – ...lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-480)L399A/L400A/I457A/L459A

Histone-lysine N-methyltransferase 2AWD repeat-containing protein 5Set1/Ash2 histone methyltransferase complex subunit ASH2Retinoblastoma-binding protein 5 experimental SAS data
Histone-lysine N-methyltransferase 2A WD repeat-containing protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Retinoblastoma-binding protein 5 Kratky plot
Sample: Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein
WD repeat-containing protein 5 monomer, 34 kDa Homo sapiens protein
Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein
Retinoblastoma-binding protein 5 monomer, 53 kDa Homo sapiens protein
Buffer: 300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2019 Jun 22
The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res (2019)
...Li T, Li Y, Li M, Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y
RgGuinier 5.3 nm
Dmax 17.2 nm
VolumePorod 313 nm3

SASDGG4 – ...lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-538)

Histone-lysine N-methyltransferase 2AWD repeat-containing protein 5Set1/Ash2 histone methyltransferase complex subunit ASH2Retinoblastoma-binding protein 5 experimental SAS data
Histone-lysine N-methyltransferase 2A WD repeat-containing protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Retinoblastoma-binding protein 5 Kratky plot
Sample: Histone-lysine N-methyltransferase 2A monomer, 25 kDa Homo sapiens protein
WD repeat-containing protein 5 monomer, 34 kDa Homo sapiens protein
Set1/Ash2 histone methyltransferase complex subunit ASH2 monomer, 60 kDa Homo sapiens protein
Retinoblastoma-binding protein 5 monomer, 59 kDa Homo sapiens protein
Buffer: 300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2019 Jun 22
The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res (2019)
...Li T, Li Y, Li M, Wang X, Peng C, Su C, Li N, Li Y, Xu Y, Chen Y
RgGuinier 5.0 nm
Dmax 15.5 nm
VolumePorod 282 nm3

SASDPP4 – Consensus SAXS Profile - Ribonuclease A

Ribonuclease pancreatic experimental SAS data
DAMMIN model
Sample: Ribonuclease pancreatic monomer, 14 kDa Bos taurus protein
Buffer: 50 mM Tris, 100 mM NaCl, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.5 nm
Dmax 4.9 nm
VolumePorod 18 nm3

SASDPQ4 – Consensus SAXS Profile - Urate Oxidase

Uricase experimental SAS data
DAMMIN model
Sample: Uricase tetramer, 136 kDa Aspergillus flavus protein
Buffer: 100 mM Tris, 150 mM NaCl, pH: 8
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 3.2 nm
Dmax 9.2 nm
VolumePorod 220 nm3

SASDPR4 – Consensus SAXS Profile - Xylose Isomerase

Xylose isomerase experimental SAS data
DAMMIN model
Sample: Xylose isomerase tetramer, 173 kDa Streptomyces rubiginosus protein
Buffer: ConsensusBuffer_50 mM Tris, 100 mM NaCl, 1 mM MgCl2, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 3.3 nm
Dmax 10.1 nm
VolumePorod 243 nm3

SASDPS4 – Consensus SAXS Profile - Xylanase

Endo-1,4-beta-xylanase experimental SAS data
DAMMIN model
Sample: Endo-1,4-beta-xylanase monomer, 21 kDa Trichoderma longibrachiatum protein
Buffer: 50 mM Tris, 100 mM NaCl, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.6 nm
Dmax 5.1 nm
VolumePorod 27 nm3

SASDPT4 – Consensus SAXS Profile - Lysozyme

Lysozyme C experimental SAS data
DAMMIN model
Sample: Lysozyme C monomer, 14 kDa Gallus gallus protein
Buffer: 50 mM sodium citrate, 150 mM NaCl, pH: 4.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.5 nm
Dmax 4.8 nm
VolumePorod 19 nm3

SASDPU4 – Consensus SANS Profile - Ribonuclease A in 100% v/v D2O buffer

Ribonuclease pancreatic experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Ribonuclease pancreatic monomer, 14 kDa Bos taurus protein
Buffer: 50 mM Tris, 100 mM NaCl, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.4 nm
Dmax 4.4 nm

SASDPV4 – Consensus SANS Profile - Lysozyme in 100% v/v D2O buffer

Lysozyme C experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Lysozyme C monomer, 14 kDa Gallus gallus protein
Buffer: 50 mM sodium citrate, 150 mM NaCl, pH: 4.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.2 nm
Dmax 3.8 nm

SASDPW4 – Consensus SANS Profile - Xylanase in 100% v/v D2O buffer

Endo-1,4-beta-xylanase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Endo-1,4-beta-xylanase monomer, 21 kDa Trichoderma longibrachiatum protein
Buffer: 50 mM Tris, 100 mM NaCl, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.5 nm
Dmax 4.4 nm

SASDPX4 – Consensus SANS Profile - Urate oxidase in 100% v/v D2O buffer

Uricase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Uricase tetramer, 136 kDa Aspergillus flavus protein
Buffer: 100 mM Tris, 150 mM NaCl, pH: 8
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 3.1 nm
Dmax 9.3 nm

SASDPY4 – Consensus SANS Profile - Xylose isomerase in 100% v/v D2O buffer

Xylose isomerase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Xylose isomerase tetramer, 173 kDa Streptomyces rubiginosus protein
Buffer: 50 mM Tris, 100 mM NaCl, 1 mM MgCl2, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 6
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 3.1 nm
Dmax 9.5 nm

SASDPZ4 – Consensus SANS Profile - Lysozyme in H2O buffer

Lysozyme C experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Lysozyme C monomer, 14 kDa Gallus gallus protein
Buffer: 50 mM sodium citrate, 150 mM NaCl, pH: 4.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 22
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.4 nm
Dmax 4.8 nm

SASDP25 – Consensus SANS Profile - Ribonuclease A in H2O buffer

Ribonuclease pancreatic experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Ribonuclease pancreatic monomer, 14 kDa Bos taurus protein
Buffer: 50 mM Tris, 100 mM NaCl, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 22
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.5 nm
Dmax 4.1 nm

SASDP35 – Consensus SANS Profile - Xylanase in H2O buffer

Endo-1,4-beta-xylanase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Endo-1,4-beta-xylanase monomer, 21 kDa Trichoderma longibrachiatum protein
Buffer: 50 mM Tris, 100 mM NaCl, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 22
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 1.6 nm
Dmax 4.3 nm

SASDP45 – Consensus SANS Profile - Urate oxidase in H2O buffer

Uricase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Uricase tetramer, 136 kDa Aspergillus flavus protein
Buffer: 100 mM Tris, 150 mM NaCl, pH: 8
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 24
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 3.2 nm
Dmax 9.1 nm

SASDP55 – Consensus SANS Profile - Xylose isomerase in H2O buffer

Xylose isomerase experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Xylose isomerase tetramer, 173 kDa Streptomyces rubiginosus protein
Buffer: 50 mM Tris, 100 mM NaCl, 1 mM MgCl2, pH: 7.5
Experiment: SANS data collected at (Consensus SAS), ...lity, Multiple countries on 2022 Jun 24
...lity and yields consensus curves for benchmarking Acta Crystallographica Section D Structural Biology 78(11) (2022)
...lilan R, Graewert M, Grishaev A, Guss J, Hammel M, Hopkins J, Huang Q, Hub J, Hura G, Irving T, Jeffries C, Jeong C, Kirby N, Krueger S, Martel A, Matsui T, Li N, Pérez J, Porcar L, Prangé T, Rajkovic...
RgGuinier 3.3 nm
Dmax 9.7 nm

SASDQ85 – Phosphofructokinase B (PfkB) from Mycobacterium marinum

Fructokinase, PfkB experimental SAS data
DAMMIF model
Sample: Fructokinase, PfkB monomer, 32 kDa Mycobacterium marinum (strain … protein
Buffer: 20 mM Tris-HCl, 100 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2019 Dec 17
Structural analysis and functional study of phosphofructokinase B (PfkB) from Mycobacterium marinum Biochemical and Biophysical Research Communications (2021)
...Li Z, Su X, Li H, Sun Y, Ji C, Gan J, Li J
RgGuinier 2.0 nm
Dmax 6.6 nm
VolumePorod 58 nm3

SASDG95 – ...linesterase 8 homolog A (Ric-8A, 1-491) and G protein complex

Resistance to inhibitors of cholinesterase 8 homolog AGuanine nucleotide-binding protein G(i) subunit alpha-1 experimental SAS data
DAMMIF model
Sample: ...linesterase 8 homolog A monomer, 56 kDa Rattus norvegicus protein
Guanine nucleotide-binding protein G(i) subunit alpha-1 monomer, 38 kDa Rattus norvegicus protein
Buffer: 25 mM HEPES, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Jul 30
Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 Nature Communications 11(1) (2020)
...Li S, Thomas C, Doukov T, Triest S, Wohlkonig A, Tall G, Steyaert J, Chiu W, Sprang S
RgGuinier 3.5 nm
Dmax 11.5 nm
VolumePorod 120 nm3

SASDX95 – ...lity protein (BRCA2) truncation containing the second, third and fourth BRC repeats (BRC2-4) at 1 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 2-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 2-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: ...lity protein (BRC repeats 2-4) monomer, 39 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) trimer, 111 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 6.5 nm
Dmax 28.5 nm
VolumePorod 334 nm3

SASDXA5 – ...lity protein (BRCA2) truncation containing the second, third and fourth BRC repeats (BRC2-4) at 2 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 2-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 2-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: ...lity protein (BRC repeats 2-4) monomer, 39 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) trimer, 111 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 6.5 nm
Dmax 28.5 nm
VolumePorod 473 nm3

SASDQB5 – Elongation factor Tu from Mycobacterium tuberculosis

Elongation factor Tu experimental SAS data
DAMMIN model
Sample: Elongation factor Tu monomer, 44 kDa Mycobacterium tuberculosis (strain … protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2021 Jul 12
Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis. Commun Biol 5(1):1052 (2022)
...Li Y, Li Z, Qi Q, Lan X, Shen H, Gan J, Zhao G, Li J
RgGuinier 3.5 nm
Dmax 9.0 nm
VolumePorod 94 nm3

SASDQC5 – Elongation factor Ts from Mycobacterium tuberculosis

Elongation factor Ts experimental SAS data
DAMMIN model
Sample: Elongation factor Ts monomer, 29 kDa Mycobacterium tuberculosis (strain … protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2021 Jul 12
Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis. Commun Biol 5(1):1052 (2022)
...Li Y, Li Z, Qi Q, Lan X, Shen H, Gan J, Zhao G, Li J
RgGuinier 2.7 nm
Dmax 10.1 nm
VolumePorod 46 nm3

SASDQD5 – Elongation factor-Tu and Elongation factor-Ts complex from Mycobacterium tuberculosis

Elongation factor TuElongation factor Ts experimental SAS data
DAMMIN model
Sample: Elongation factor Tu monomer, 44 kDa Mycobacterium tuberculosis (strain … protein
Elongation factor Ts monomer, 29 kDa Mycobacterium tuberculosis (strain … protein
Buffer: 20 mM Tris, 100 mM NaCl, pH: 8
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2021 Jul 12
Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis. Commun Biol 5(1):1052 (2022)
...Li Y, Li Z, Qi Q, Lan X, Shen H, Gan J, Zhao G, Li J
RgGuinier 3.1 nm
Dmax 11.2 nm
VolumePorod 111 nm3

SASDQE5 – Nucleoside triphosphate pyrophosphohydrolase (1–185)

Nucleoside triphosphate pyrophosphohydrolase experimental SAS data
DAMMIF model
Sample: Nucleoside triphosphate pyrophosphohydrolase dimer, 41 kDa Mycobacterium tuberculosis (strain … protein
Buffer: 20 mM Tris-HCl, 100 mM NaCl, pH: 7.5
Experiment: SAXS data collected at BL19U2, ...lity (SSRF) on 2020 Dec 11
Structural analysis of the housecleaning nucleoside triphosphate pyrophosphohydrolase MazG from Mycobacterium tuberculosis Frontiers in Microbiology 14 (2023)
...Li J
RgGuinier 2.7 nm
Dmax 8.4 nm
VolumePorod 64 nm3

SASDGP5 – Vibrio cholerae DciA

DciA experimental SAS data
DciA Kratky plot
Sample: DciA monomer, 18 kDa Vibrio cholerae serotype … protein
Buffer: 20 mM Tris-HCl, 100 mM NaCl, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2017 Mar 26
...licative helicase. Nucleic Acids Res (2021)
...Li de la Sierra-Gallay I, Humbert A, Aumont-Nicaise M, Velours C, Ochsenbein F, Durand D, Le Cam E, Walbott H, Possoz C, Quevillon-Cheruel S, Ferat JL
RgGuinier 2.7 nm
Dmax 10.1 nm
VolumePorod 26 nm3

SASDGQ5 – ...licase with bound ATP (VcDnaB.ATP)

Replicative DNA helicase (DnaB) experimental SAS data
Replicative DNA helicase (DnaB) Kratky plot
Sample: ...licative DNA helicase (DnaB) hexamer, 317 kDa Vibrio cholerae serotype … protein
Buffer: 20 mM Tris-HCl, 100 mM NaCl, 1 mM ATP, pH: 8.8
Experiment: SAXS data collected at SWING, SOLEIL on 2018 Oct 4
...licative helicase. Nucleic Acids Res (2021)
...Li de la Sierra-Gallay I, Humbert A, Aumont-Nicaise M, Velours C, Ochsenbein F, Durand D, Le Cam E, Walbott H, Possoz C, Quevillon-Cheruel S, Ferat JL
RgGuinier 4.6 nm
Dmax 13.0 nm
VolumePorod 585 nm3

SASDGR5 – ...licase complex in the presence of bound ATP (VcDnaB.DciA.ATP)

DnaB helicase complexed with ATPDciA experimental SAS data
DnaB helicase complexed with ATP DciA Kratky plot
Sample: ...licase complexed with ATP hexamer, 317 kDa Vibrio cholerae serotype … protein
DciA , 55 kDa Vibrio cholerae serotype … protein
Buffer: 20 mM Tris-HCl, 100 mM NaCl, 1 mM ATP, pH: 8.8
Experiment: SAXS data collected at SWING, SOLEIL on 2018 Oct 4
...licative helicase. Nucleic Acids Res (2021)
...Li de la Sierra-Gallay I, Humbert A, Aumont-Nicaise M, Velours C, Ochsenbein F, Durand D, Le Cam E, Walbott H, Possoz C, Quevillon-Cheruel S, Ferat JL
RgGuinier 5.0 nm
Dmax 15.6 nm
VolumePorod 670 nm3

SASDWT5 – N-terminal truncated RAD51 in complex with fourth BRC repeat (BRC4) SEC-SAXS

Breast cancer type 2 susceptibility protein (BRC repeat 4)DNA repair protein RAD51 homolog 1 (Δ97) experimental SAS data
ALPHAFOLD model
Sample: ...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (Δ97) monomer, 26 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 1 mM DTT, 2% sucrose, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 May 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.0 nm
Dmax 6.6 nm
VolumePorod 57 nm3

SASDWU5 – N-terminal truncated RAD51 in complex with fourth BRC repeat (BRC4) at 1 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeat 4)DNA repair protein RAD51 homolog 1 (Δ97) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeat 4) DNA repair protein RAD51 homolog 1 (Δ97) Kratky plot
Sample: ...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (Δ97) monomer, 26 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.0 nm
Dmax 6.3 nm
VolumePorod 51 nm3

SASDWV5 – N-terminal truncated RAD51 in complex with fourth BRC repeat (BRC4) at 2 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeat 4)DNA repair protein RAD51 homolog 1 (Δ97) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeat 4) DNA repair protein RAD51 homolog 1 (Δ97) Kratky plot
Sample: ...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (Δ97) monomer, 26 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.1 nm
Dmax 6.6 nm
VolumePorod 49 nm3

SASDWW5 – N-terminal truncated RAD51 in complex with fourth BRC repeat (BRC4) at 4 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeat 4)DNA repair protein RAD51 homolog 1 (Δ97) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeat 4) DNA repair protein RAD51 homolog 1 (Δ97) Kratky plot
Sample: ...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (Δ97) monomer, 26 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.1 nm
Dmax 6.3 nm
VolumePorod 57 nm3

SASDWX5 – N-terminal truncated RAD51 in complex with fourth BRC repeat (BRC4) at 6 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeat 4)DNA repair protein RAD51 homolog 1 (Δ97) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeat 4) DNA repair protein RAD51 homolog 1 (Δ97) Kratky plot
Sample: ...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (Δ97) monomer, 26 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.1 nm
Dmax 6.6 nm
VolumePorod 63 nm3

SASDWY5 – RAD51 [F86E, A89E] in complex with fourth BRC repeat (BRC4) SEC-SAXS

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 4) experimental SAS data
ALPHAFOLD model
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 1 mM DTT, 2% sucrose, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 May 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.8 nm
Dmax 10.5 nm
VolumePorod 74 nm3

SASDAZ5 – NetrinVIV

Netrin-1 experimental SAS data
DAMMIN model
Sample: Netrin-1 monomer, 49 kDa Homo sapiens protein
Buffer: 25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Aug 26
...lity of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
...LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang JH, Meijers R
RgGuinier 3.9 nm
Dmax 13.5 nm
VolumePorod 100 nm3

SASDWZ5 – RAD51 [F86E, A89E] in complex with fourth BRC repeat (BRC4) at 0.5 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 4) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 4) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.8 nm
Dmax 11.0 nm
VolumePorod 67 nm3

SASDA26 – DCC56

Deleted in Colorectal Cancer (FN5 & FN6) experimental SAS data
DAMMIN model
Sample: Deleted in Colorectal Cancer (FN5 & FN6) monomer, 26 kDa Homo sapiens protein
Buffer: 25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Aug 26
...lity of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
...LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang JH, Meijers R
RgGuinier 3.2 nm
Dmax 11.0 nm
VolumePorod 38 nm3

SASDW26 – RAD51 [F86E, A89E] in complex with fourth BRC repeat (BRC4) at 1 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 4) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 4) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.7 nm
Dmax 10.0 nm
VolumePorod 64 nm3

SASDW36 – RAD51 [F86E, A89E] in complex with fourth BRC repeat (BRC4) at 2 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 4) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 4) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.7 nm
Dmax 10.3 nm
VolumePorod 66 nm3

SASDW46 – RAD51 [F86E, A89E] in complex with fourth BRC repeat (BRC4) at 4 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 4) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 4) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 4) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.8 nm
Dmax 10.0 nm
VolumePorod 72 nm3

SASDW56 – RAD51 [F86E, A89E] in complex with second BRC repeat (BRC2) SEC-SAXS

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 2) experimental SAS data
ALPHAFOLD model
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 2) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 1 mM DTT, 2% sucrose, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 May 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.7 nm
Dmax 9.6 nm
VolumePorod 67 nm3

SASDW66 – RAD51 [F86E, A89E] in complex with second BRC repeat (BRC2) at 0.5 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 2) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.6 nm
Dmax 9.5 nm
VolumePorod 83 nm3

SASDA76 – NetrinVIV DCC56 complex

Netrin-1Deleted in Colorectal Cancer (FN5 & FN6) experimental SAS data
Netrin-1 Deleted in Colorectal Cancer (FN5 & FN6) Kratky plot
Sample: Netrin-1 monomer, 49 kDa Homo sapiens protein
Deleted in Colorectal Cancer (FN5 & FN6) monomer, 26 kDa Homo sapiens protein
Buffer: 25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Oct 31
...lity of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
...LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang JH, Meijers R
RgGuinier 5.1 nm
Dmax 17.0 nm
VolumePorod 120 nm3

SASDW76 – RAD51 [F86E, A89E] in complex with second BRC repeat (BRC2) at 1 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 2) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.7 nm
Dmax 9.6 nm
VolumePorod 63 nm3

SASDA86 – NetrinVIV DCC56(M933R) complex

Netrin-1Deleted in Colorectal Cancer (FN5 & FN6) M933R mutant experimental SAS data
Netrin-1 Deleted in Colorectal Cancer (FN5 & FN6) M933R mutant Kratky plot
Sample: Netrin-1 monomer, 49 kDa Homo sapiens protein
Deleted in Colorectal Cancer (FN5 & FN6) M933R mutant monomer, 26 kDa Homo sapiens protein
Buffer: 25 MES mM 200 mM NaCl 50 mM Tris 0.2 M ammonium sulfate (NH4)2(SO4) 1mM calcium chloride CaCl2, pH: 7
Experiment: SAXS data collected at EMBL P12, PETRA III on 2013 Aug 26
...lity of netrin-1 as a guidance cue. Neuron 83(4):839-849 (2014)
...LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y, Wang JH, Meijers R
RgGuinier 4.0 nm
Dmax 14.0 nm
VolumePorod 95 nm3

SASDR86 – Human Survivin (BIRC5)

Baculoviral IAP repeat-containing protein 5 experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Baculoviral IAP repeat-containing protein 5 dimer, 34 kDa Homo sapiens protein
Buffer: 50 mM Tris, 150 mM NaCl, 1 mM DTT, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2023 Jan 10
Survivin prevents the Polycomb Repressor Complex 2 from methylating Histone 3 lysine 27 iScience :106976 (2023)
...Li S, Anindya A, Andersson K, Erlandsson M, Oparina N, Burmann B, Brath U, Panchenko A, Maria Bokarewa I, Katona G
RgGuinier 2.9 nm
Dmax 10.4 nm
VolumePorod 53 nm3

SASDW86 – RAD51 [F86E, A89E] in complex with second BRC repeat (BRC2) at 2 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeat 2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeat 2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) monomer, 37 kDa Homo sapiens protein
...lity protein (BRC repeat 2) monomer, 4 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 2.7 nm
Dmax 9.8 nm
VolumePorod 69 nm3

SASDW96 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second and the third BRC repeats (BRC2-3) SEC-SAXS

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 2-3) experimental SAS data
ALPHAFOLD model
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
...lity protein (BRC repeats 2-3) monomer, 28 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 1 mM DTT, 1% sucrose, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 5.5 nm
Dmax 23.0 nm
VolumePorod 167 nm3

SASDFA6 – Proteolytic fragment of phage flagella binding tail protein YSD1_29 (amino acids 373-1296)

Flagella binding tail protein experimental SAS data
DAMMIF model
Sample: Flagella binding tail protein monomer, 103 kDa Salmonella virus Chi protein
Buffer: 20 mM Tris, 150 mM NaCl, 0.03 % NaN3, 5.0 % glycerol, pH: 7.8
Experiment: SAXS data collected at SAXS/WAXS, ...lian Synchrotron on 2017 Apr 4
...like protein tail fibre. Mol Microbiol (2019)
...Li F, Grinter R, Harcourt K, Yu L, Song J, Schreiber F, Choudhary J, Clare S, Coulibaly F, Strugnell RA, Dougan G, Lithgow T
RgGuinier 5.6 nm
Dmax 27.4 nm
VolumePorod 155 nm3

SASDWA6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second and the third BRC repeats (BRC2-3) at 0.5 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 2-3) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 2-3) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
...lity protein (BRC repeats 2-3) monomer, 28 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 6.0 nm
Dmax 21.0 nm
VolumePorod 236 nm3

SASDWB6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second and the third BRC repeats (BRC2-3) at 1 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 2-3) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 2-3) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
...lity protein (BRC repeats 2-3) monomer, 28 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 5.7 nm
Dmax 23.0 nm
VolumePorod 225 nm3

SASDWC6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second and the third BRC repeats (BRC2-3) at 2 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 2-3) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 2-3) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
...lity protein (BRC repeats 2-3) monomer, 28 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 5.7 nm
Dmax 22.0 nm
VolumePorod 167 nm3

SASDWD6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the second, third and fourth BRC repeats (BRC2-4) SEC-SAXS

Breast cancer type 2 susceptibility protein (BRC repeats 2-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
ALPHAFOLD model
Sample: ...lity protein (BRC repeats 2-4) monomer, 39 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) trimer, 111 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 1 mM DTT, 1% sucrose, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 6.7 nm
Dmax 28.0 nm
VolumePorod 259 nm3

SASDWE6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the third and fourth BRC repeats (BRC3-4) SEC-SAXS

Breast cancer type 2 susceptibility protein (BRC repeats 3-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
ALPHAFOLD model
Sample: ...lity protein (BRC repeats 3-4) monomer, 16 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 1 mM DTT, 2% sucrose, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 May 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 4.6 nm
Dmax 18.0 nm
VolumePorod 142 nm3

SASDAF6 – K1K2K3 domain of Kgp gingipain

K1K2K3 adhesin modules of lysine-specific (Kgp) gingipain experimental SAS data
BUNCH model
Sample: K1K2K3 adhesin modules of lysine-specific (Kgp) gingipain monomer, 74 kDa ...lis W83 protein
Buffer: 10 mM TRIS 150 mM NaCl, pH: 7.6
Experiment: SAXS data collected at Anton Paar SAXSess, University of Sydney on 2010 Aug 15
...lis. Mol Microbiol 81(5):1358-73 (2011)
Li N, Yun P, Jeffries CM, Langley D, Gamsjaeger R, Church WB, Hunter N, Collyer CA
RgGuinier 4.3 nm
Dmax 14.7 nm

SASDWF6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the third and fourth BRC repeats (BRC3-4) at 0.5 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 3-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 3-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: ...lity protein (BRC repeats 3-4) monomer, 16 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 4.6 nm
Dmax 18.5 nm
VolumePorod 175 nm3

SASDAG6 – K1K2 domains of Kgp gingipain

K1K2 adhesin modules of lysine-specific (Kgp) gingipain experimental SAS data
BUNCH model
Sample: K1K2 adhesin modules of lysine-specific (Kgp) gingipain monomer, 38 kDa ...lis W83 protein
Buffer: 10 mM TRIS 150 mM NaCl, pH: 7.6
Experiment: SAXS data collected at Anton Paar SAXSess, University of Sydney on 2010 Aug 15
...lis. Mol Microbiol 81(5):1358-73 (2011)
Li N, Yun P, Jeffries CM, Langley D, Gamsjaeger R, Church WB, Hunter N, Collyer CA
RgGuinier 2.9 nm
Dmax 9.5 nm

SASDWG6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the third and fourth BRC repeats (BRC3-4) at 1 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 3-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 3-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: ...lity protein (BRC repeats 3-4) monomer, 16 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 4.5 nm
Dmax 18.0 nm
VolumePorod 140 nm3

SASDWH6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the third and fourth BRC repeats (BRC3-4) at 2 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 3-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 3-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: ...lity protein (BRC repeats 3-4) monomer, 16 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 4.6 nm
Dmax 18.3 nm
VolumePorod 148 nm3

SASDWJ6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first and the second BRC repeats (BRC1-2) SEC-SAXS

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 1-2) experimental SAS data
ALPHAFOLD model
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
...lity protein (BRC repeats 1-2) monomer, 28 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 1 mM DTT, 2% sucrose, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 May 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 5.3 nm
Dmax 21.0 nm
VolumePorod 165 nm3

SASDWK6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first and the second BRC repeats (BRC1-2) at 0.5 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 1-2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 1-2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
...lity protein (BRC repeats 1-2) monomer, 28 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 5.7 nm
Dmax 24.0 nm
VolumePorod 249 nm3

SASDWL6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first and the second BRC repeats (BRC1-2) at 1 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 1-2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 1-2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
...lity protein (BRC repeats 1-2) monomer, 28 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 5.5 nm
Dmax 21.0 nm
VolumePorod 208 nm3

SASDWM6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first and the second BRC repeats (BRC1-2) at 2 mg/mL

DNA repair protein RAD51 homolog 1 (F86E A89E)Breast cancer type 2 susceptibility protein (BRC repeats 1-2) experimental SAS data
DNA repair protein RAD51 homolog 1 (F86E A89E) Breast cancer type 2 susceptibility protein (BRC repeats 1-2) Kratky plot
Sample: DNA repair protein RAD51 homolog 1 (F86E A89E) dimer, 74 kDa Homo sapiens protein
...lity protein (BRC repeats 1-2) monomer, 28 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Jul 1
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 5.5 nm
Dmax 23.0 nm
VolumePorod 191 nm3

SASDWN6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first, second, third and fourth BRC repeats (BRC1-4) SEC-SAXS

Breast cancer type 2 susceptibility protein (BRC repeats 1-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
ALPHAFOLD model
Sample: ...lity protein (BRC repeats 1-4) monomer, 62 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) tetramer, 148 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 1 mM DTT, 1% sucrose, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 7.7 nm
Dmax 34.0 nm
VolumePorod 409 nm3

SASDWP6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first, second, third and fourth BRC repeats (BRC1-4) at 0.5 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 1-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 1-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: ...lity protein (BRC repeats 1-4) monomer, 62 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) tetramer, 148 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 8.1 nm
Dmax 33.0 nm
VolumePorod 422 nm3

SASDWQ6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first, second, third and fourth BRC repeats (BRC1-4) at 0.98 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 1-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 1-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: ...lity protein (BRC repeats 1-4) monomer, 62 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) tetramer, 148 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 7.6 nm
Dmax 33.3 nm
VolumePorod 392 nm3

SASDWR6 – RAD51 [F86E, A89E] in complex with BRCA2 truncation containing the first, second, third and fourth BRC repeats (BRC1-4) at 2 mg/mL

Breast cancer type 2 susceptibility protein (BRC repeats 1-4)DNA repair protein RAD51 homolog 1 (F86E A89E) experimental SAS data
Breast cancer type 2 susceptibility protein (BRC repeats 1-4) DNA repair protein RAD51 homolog 1 (F86E A89E) Kratky plot
Sample: ...lity protein (BRC repeats 1-4) monomer, 62 kDa Homo sapiens protein
DNA repair protein RAD51 homolog 1 (F86E A89E) tetramer, 148 kDa Homo sapiens protein
Buffer: ...Li₂SO₄, 5% glycerol, 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, ...Light Source on 2024 Dec 2
Breaking new ground into RAD51–BRC repeats interplay in Homologous Recombination (2025)
...li A
RgGuinier 7.7 nm
Dmax 33.0 nm
VolumePorod 417 nm3